Roles of bone marrow specific endothelial cells in the process of engraftment after hematopoietic stem cell transplantation
| Project/Area Number |
16K09866
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
服部 浩一 順天堂大学, 医学(系)研究科(研究院), 特任先任准教授 (10360116)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 血液免疫学 / 血管内皮造血転換 / 造血幹細胞 / 増血促進 / 細胞・組織 / シグナル伝達 / 生体分子 / アンジオクライン因子 / 造血促進 |
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| Outline of Final Research Achievements |
We could show that endothelial lineage cells which are one of the hematopoietic niche components play a key role in hematopoiesis in the bone marrow through the interaction with other lineage cells like mesenchymal stromal cell, mesenchymal stem cell and hematopoietic stem cell. A new concept in the hematology field is that of angiocrine factors that under pathophysiological conditions are released from endothelial cells so-called bone marrow specific endothelial cells and can promote hematopoiesis in bone marrow through a directly or indirectly mechanism. Therefore, we suggest that an abnormal function of endothelial lineage cells induces or exacerbates graft failure after hematopoietic stem cell transplantation represented by cord blood transplantation. Based on our study, we could present important data for the discussion about the clinical utility of cotransplatation with hematopoietic stem cells and endothelial lineage cells as a treatment of graft failure in the near future.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の成果を通じて、現行の臍帯血移植の最大の問題点である生着不全の病態での血管内皮系細胞の関与を明確化することによって、臍帯血移植において血管内皮系細胞との共移植の可能性について検討するための基盤的な情報を得ることができたと考えている。
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Which is more important for the selection of cord blood units for haematopoietic cell transplantation: the number of CD34-positive cells or total nucleated cells?2018
Author(s)
Nakasone H, Tabuchi K, Uchida N, Ohno Y, Matsuhashi Y, Takahashi S, Onishi Y, Onizuka M, Kobayashi H, Fukuda T, Ichinohe T, Takanashi M, Kato K, Atsuta Y, Yabe H, Kanda Y.
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Journal Title
Br J Haematol.
Volume: -
Issue: 1
Pages: 166-169
DOI
Related Report
Peer Reviewed
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[Journal Article] Refractory Graft-Versus-Host Disease-Free, Relapse-Free Survival as an Accurate and Easy-to-Calculate Endpoint to Assess the Long-Term Transplant Success.2018
Author(s)
Kawamura K, Nakasone H, Kurosawa S, Yoshimura K, Misaki Y, Gomyo A, Hayakawa J, Tamaki M, Akahoshi Y, Kusuda M, Kameda K, Wada H, Ishihara Y, Sato M, Terasako-Saito K, Kikuchi M, Kimura SI, Tanihara A, Kako S, Kanamori H, Mori T, Takahashi S, Taniguchi S, Atsuta Y, Kanda Y.
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Journal Title
Biol Blood Marrow Transplant.
Volume: 24(7)
Issue: 7
Pages: 1521-1526
DOI
Related Report
Peer Reviewed
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[Journal Article] HLA discrepancy between graft and host rather than that graft and first donor impact the second transplant outcome.2018
Author(s)
Maeda Y, Ugai T, Kondo E, Ikegame K, Murata M, Uchida N, Miyamoto T, Takahashi S, Ohashi K, Nakamae H, Fukuda T, Onizuka M, Eto T, Ota S, Hirokawa M, Ichinohe T, Atsuta Y, Kanda Y, Kanda J.
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Journal Title
Haematologica.
Volume: Dec.6
Issue: 5
Pages: 1055-1061
DOI
Related Report
Peer Reviewed
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[Journal Article] Quality of Life after Allogeneic Hematopoietic Cell Transplantation According to Affected Organ and Severity of Chronic Graft-versus-Host Disease2017
Author(s)
Kurosawa S, Oshima K, Yamaguchi T, Yanagisawa A, Fukuda T, Kanamori H, Mori T, Takahashi S, Kondo T, Kohno A, Miyamura K, Umemoto Y, Teshima T, Taniguchi S, Yamashita T1 Inamoto Y, Kanda Y, Okamoto S, Atsuta Y.
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Journal Title
Biology of Blood and Marrow Transplantation
Volume: 23
Issue: 10
Pages: 1749-1758
DOI
Related Report
Peer Reviewed
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[Journal Article] Pharmacological targeting of plasmin prevents lethality and tissue damage in a murine model of macrophage activation syndrome2017
Author(s)
1.Shimazu H, Munakata S, Tashiro Y, Salama Y, Eiamboonser S, Ohta Y, Onoda H, Tsuda Y, Okada Y, Nakauchi H, Heissig B and Hattori K
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Journal Title
Blood
Volume: 印刷中
Issue: 1
Pages: 59-72
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Impact of graft-versus-host disease on outcomes after unrelated cord blood transplantation.2017
Author(s)
Kanda J, Morishima Y, Terakura S, Wake A, Uchida N, Takahashi S, Ono Y, Onishi Y, Kanamori H, Aotsuka N, Ozawa Y, Ogawa H, Sakura T, Ohashi K, Ichinohe T, Kato K, Atsuta Y, Teshima T, Murata M.
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Journal Title
Leukemia
Volume: 31(3)
Issue: 3
Pages: 663-668
DOI
Related Report
Peer Reviewed / Open Access
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