| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
We demonstrated that HMGB1 (High Mobility Group Box 1) was released from recipient organs damaged by preconditioning regimen, and activated innate immune system and cause inflammatory reaction. Then, it has been clarified that neutrophils and eosinophils migrate to target organs, and promote the progression of chronic GVHD (graft-versus-host disease). Inhibition of HMGB1 by DPP4 may have an indirect effect rather than a direct effect.
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