| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
C/EBPα is critical for acute myeloid leukemia and plays a role in granulopoiesis. The C-terminus of the C/EBPα molecule functionally and physically interacts with GABP to activate the human myeloid IgA Fc receptor (FCAR) promoter. Previous study identified the C/EBPα C-terminus as an essential domain for granulopoiesis of K562 cells. In this study, I identified a polycomb component RING1B as the interactor of the C/EBPα C-terminus, suggesting its involvement in epigenetic regulation.
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