Development of new biomarker for ANCA associated vasculitis using serum micro RNA

• Project/Area Number: 16K09895
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Collagenous pathology/Allergology
• Research Institution: Okayama University
• Principal Investigator: Ken-ei Sada 岡山大学, 医歯薬学総合研究科, 准教授 (70423308)
• Research Collaborator: KATSUYAMA TAKAYUKI ; WATANABE HARUKI
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: ANCA関連血管炎 / マイクロRNA / microRNA / 膠原病学 / バイオマーカー / 血管炎

Outline of Final Research Achievements

MicroRNA, adjusting genome expression, is expected as biomarker of diagnosis or activity in autoimmune diseases. In this study, we evaluated usefulness of microRNA in ANCA associated vasculitis. We found on miR-5571 and miR-200c based on comprehensive search. We found that miR-5571 associated with MPO-ANCA positivity and miR-200c related with disease activity statistically.

Academic Significance and Societal Importance of the Research Achievements

miR-5571は疾患特異的な診断マーカー、miR-200cは疾患活動性のマーカーとなることが示唆された。これらのマイクロRNAのさらなる検討によってANCA関連血管炎の病態解明や臨床的なバイオマーカーとしての利用により、有効かつ安全な治療法の開発が期待される。