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Epigenetic aberration and pathologic analysis in peripheral blood of adult-onset still's disease

Research Project

Project/Area Number 16K09902
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Collagenous pathology/Allergology
Research InstitutionSaitama Medical University

Principal Investigator

Mimura Toshihide  埼玉医科大学, 医学部, 教授 (30260491)

Research Collaborator KUROKAWA riki  
NOMA hisashi  
ARAKI yasuto  
KUROSAWA natsuko  
AIZAKI yoshimi  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsエピジェネティクス / ヒストンメチル化 / エピジェティクス / 成人スティル病 / ヒストン修飾 / エピゲノム / 内科 / 免疫学 / 末梢血
Outline of Final Research Achievements

1) Histone modification in peripheral blood nucleated cells from adult-onset Still's disease (AOSD) was detected by flow cytometric analysis using specific antibodies against H3K4me3 or H3K27me3. There were specific aberrations of histone methylation in monocytes, neutrophils and B cells from AOSD patients comparing with healthy controls or other disease controls. Of interest was these histone methylation abnormalities were significantly associated with disease activity. Additionally aberrant histone methylations of a specific subset of monocyte with CD14++CD16- were significantly correlated with serum IL-18 concentration.
2) To analyze the pathogenic mechanism of AOSD from epigenetic point of view, ATAC-Seq was performed to identify genes with open chromatins. However, the technique showed nothing and an alternative method was carried out. We made transcriptome analysis and found several candidates of the target genes. We now preparing for ChIP-Seq analysis for the purpose above.

Academic Significance and Societal Importance of the Research Achievements

この研究においては、病気の原因の不明な成人発症スチル病(AOSD)の原因を解明するために、血液中の白血球のエピゲノム異常(遺伝子に変化を認めないけれどタンパク質の発現には変化が見られる制御機構)、特にヒストン修飾変化を各細胞亜群毎に解明する研究で、私達は単球という細胞群においてヒストンのメチル化異常を認めた。さらに、このメチル化異常の結果、どのような遺伝子の発現に変化が見られるのかを明らかにした。それを基に、この結果が蛋白の発現に影響するのか、そしてどのように病気の状態に関与するのか現在も研究を進めています。これが明らかになれば、新規治療法の開発に繋がる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (59 results)

All 2019 2018 2017 2016 Other

All Journal Article (11 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 11 results,  Open Access: 7 results,  Acknowledgement Compliant: 3 results) Presentation (35 results) (of which Int'l Joint Research: 11 results,  Invited: 2 results) Book (10 results) Remarks (3 results)

  • [Journal Article] Urinary levels of the leukocyte surface molecule CD11b associate with glomerular inflammation in lupus nephritis.2019

    • Author(s)
      Kitagawa A, Tsuboi N, Yokoe Y, Katsuno T, Ikeuchi H, Kajiyama H, Endo N, Sawa Y, Suwa J, Sugiyama Y, Hachiya A, Mimura T, Hiromura K, Maruyama S.
    • Journal Title

      Kidney Int.

      Volume: 95(3) Issue: 3 Pages: 680-692

    • DOI

      10.1016/j.kint.2018.10.025

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Evidence-based clinical practice guideline for adult Still’s disease2018

    • Author(s)
      Mimura T, Kondo Y, et al.
    • Journal Title

      Mod Rheumatol, in press

      Volume: 28 Issue: 5 Pages: 736

    • DOI

      10.1080/14397595.2018.1465633

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Altered gene expression profiles of histone lysine methyltransferases and demethylases in rheumatoid arthritis synovial fibroblasts2018

    • Author(s)
      Araki, Y., Aizaki, Y., Sato, K., Oda, H., Kurokawa, R., Mimura, T
    • Journal Title

      Clin Exp Rheumatol

      Volume: 36 Pages: 314-316

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Splicing variant ofWDFY4augments MDA5 signalling and the risk of clinically amyopathic dermatomyositis2018

    • Author(s)
      Kochi Yuta et al.
    • Journal Title

      Annals of the Rheumatic Diseases

      Volume: 77 Issue: 4 Pages: 602-611

    • DOI

      10.1136/annrheumdis-2017-212149

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Detection of synovial inflammation in rheumatic diseases using superb microvascular imaging: Comparison with conventional power Doppler imaging2018

    • Author(s)
      Yokota K, Wada T, Akiyama Y, Mimura T
    • Journal Title

      Mod Rheumatol

      Volume: 28 Issue: 2 Pages: 327-333

    • DOI

      10.1080/14397595.2017.1337288

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The correlation of urinary podocytes and podocalyxin with histological features of lupus nephritis.2018

    • Author(s)
      Ikuma D, Hiromura K, Kajiyama H, Suwa J, Ikeuchi H, Sakairi T, Kaneko Y, Maeshima A, Kurosawa H, Hirayama Y, Yokota K, Araki Y, Sato K, Asanuma YF, Akiyama Y, Hara M, Nojima Y, Mimura T
    • Journal Title

      Lupus

      Volume: 27 Issue: 3 Pages: 484-493

    • DOI

      10.1177/0961203317734918

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Matrix metalloproteinase gene activation resulting from disordered epigenetic mechanisms in rheumatoid arthritis2017

    • Author(s)
      Araki Y, Mimura T
    • Journal Title

      Int J Mol Sci

      Volume: 18 Issue: 5 Pages: 905-905

    • DOI

      10.3390/ijms18050905

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The histone modification code in the pathogenesis of autoimmune diseases2017

    • Author(s)
      Araki Y, Mimura T
    • Journal Title

      Mediators of Inflammation

      Volume: 2017 Pages: 2608605-2608605

    • DOI

      10.1155/2017/2608605

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Histone Methylation and STAT-3 Differentially Regulate Interleukin-6-Induced Matrix Metalloproteinase Gene Activation in Rheumatoid Arthritis Synovial Fibroblasts.2016

    • Author(s)
      Araki Y, Tsuzuki Wada T, Aizaki Y, Sato K, Yokota K, Fujimoto K, Kim YT, Oda H, Kurokawa R, Mimura
    • Journal Title

      Arthritis Rheumatol.

      Volume: 68 Issue: 5 Pages: 1111-23

    • DOI

      10.1002/art.39563

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A novel method predicting clinical response using only background clinical data in RA patients before treatment with infliximab2016

    • Author(s)
      Miyoshi F, Honne K, Minota S, Okada M, Ogawa N, Mimura T
    • Journal Title

      Mod Rheumatol

      Volume: 26 Issue: 6 Pages: 813-816

    • DOI

      10.3109/14397595.2016.1168536

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] The mechanisms underlying chronic inflammation in rheumatoid arthritis from the perspective of the epigenetic landscape2016

    • Author(s)
      Araki Y, Mimura T
    • Journal Title

      Journal of Immunology Research

      Volume: 2016 Pages: 6290682-6290682

    • DOI

      10.1155/2016/6290682

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Retrospective Analysis of 30 Patients with Limited Cutaneous Systemic Sclerosis for 20 Years.2018

    • Author(s)
      Akiyama, Y., Yoshida, Y., Yokota, K., Araki, Y., Funakubo, Y., Sato, K., Mimura, T
    • Organizer
      11th International Congress on Autoimmunity.
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The Comparative Observational Study about Efficacy, Safety and Adherence between Tocilizumab and Infliximab in Patients with Rheumatoid Arthritis.2018

    • Author(s)
      Matsuda, M., Funakubo Asanuma, Yu., Nakao, Y., Yazawa, H,, Tsuzuki Wada, T., Kouzu, N., Mimura, T
    • Organizer
      2018 ACR/ARHPAnnual Meeting.
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The Efficacy, Safety and Adherence of Biologicbiological Disease-Modifying Anti Rheumatic Drugs, Infliximab, Tocilizumab and Abatacept, in Elderly Patients with Rheumatoid Arthritis.2018

    • Author(s)
      Tsuzuki Wada, T., Funakubo Asanuma, Yu., Matsuda, M., Yazawa, H., Nakao, Y., Kozu, N., Mimura, T
    • Organizer
      2018 ACR/ARHPAnnual Meeting.
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In the Presence of IL-18, IL-10 but Not IL-6 Induces IFN-γ Production and the Surface Expression of TRAIL on NK Cells.2018

    • Author(s)
      Sato, K., Aizaki, Y., Yazawa, H., Mimura, T
    • Organizer
      2018 ACR/ARHPAnnual Meeting.
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Detection of Precursors of RANK- Osteoclast-like Cells (Olcs) in Peripheral Blood and Olcs in Bone Tissue from Rheumatoid Arthritis Patients.2018

    • Author(s)
      Yokota, K., Tanaka, S., Sekikawa, M., Aizaki, Y., Sato, K., Oda, H., Mimura, T
    • Organizer
      2018 ACR/ARHPAnnual Meeting.
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 成人Still病の診断と治療.2018

    • Author(s)
      三村俊英
    • Organizer
      第115回日本内科学会総会・講演会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 全身性エリテマトーデスにおける尿中ポドサイトマーカー測定の意義2018

    • Author(s)
      梶山浩,廣村桂樹,井熊大輔,諏訪絢也,池内秀和,黒沢寛之,平山吉朗,原正則,野島美久,三村俊英
    • Organizer
      第115回日本内科学会総会・講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] EBウイルス陽性を示した症例へ生物学的製剤を使用した自験8例の検討.2018

    • Author(s)
      吉田佳弘,横田和浩,佐藤浩二郎,舟久保ゆう,三村俊英
    • Organizer
      第62回日本リウマチ学会総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 当科における関節リウマチに対するアバタセプトとゴリムマブの治療成績(208週)の比較検討.2018

    • Author(s)
      .秋山雄次,和田琢,高松真裕子,丸山崇,柳澤麻依子,吉田佳弘,立花秀介,横田和浩,梶山浩,荒木靖人,佐藤浩二郎,舟久保ゆう,三村俊英
    • Organizer
      第62回日本リウマチ学会総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 自己免疫性好中球減少症を合併したシェーグレン症候群の1例.2018

    • Author(s)
      丸山崇,伊藤達也,三村俊英,秋山雄次
    • Organizer
      第62回日本リウマチ学会総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Ninja2012とNinja2016における関節リウマチ患者の腎機能と治療内容の比較.2018

    • Author(s)
      梶山浩,野間久史,津野宏隆,橋本篤,松井利浩,金子敦史,角田慎一郎,横田和浩,荒木靖人,佐藤浩二郎,舟久保ゆう,税所幸一郎,西野仁樹,當間重人,三村俊英
    • Organizer
      第62回日本リウマチ学会総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 全身性エリテマトーデス外来維持療法患者におけるヒドロキシクロロキン追加投与の効果と安全性.2018

    • Author(s)
      梶山浩,吉田佳弘,横田和浩,荒木靖人,佐藤浩二郎,舟久保ゆう,三村俊英
    • Organizer
      第62回日本リウマチ学会総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 高齢関節リウマチ患者におけるトシリズマブの有効性,安全性,継続率の検討.2018

    • Author(s)
      中尾嘉修,松田真弓,矢澤宏晃,神津教倫,佐藤浩二郎,舟久保ゆう,三村俊英
    • Organizer
      第62回日本リウマチ学会総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 関節リウマチ患者におけるインフリキシマブの増量・投与間隔短縮の承認前後における安全性と忍容性の比較検討.2018

    • Author(s)
      矢澤宏晃,松田真弓,中尾嘉修,神津教倫,佐藤浩二郎,舟久保ゆう,三村俊英
    • Organizer
      第62回日本リウマチ学会総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] インフリキシマブまたはトシリズマブで治療された関節リウマチ患者における有効性,安全性,継続率の比較.2018

    • Author(s)
      松田真弓,舟久保ゆう,中尾嘉修,矢澤宏晃,神津教倫,佐藤浩二郎,三村俊英
    • Organizer
      第62回日本リウマチ学会総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ベーチェット病患者の末梢血白血球におけるヒストンメチル化の解析.2018

    • Author(s)
      相崎良美,荒木靖人,三村俊英
    • Organizer
      第62回日本リウマチ学会総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 当科における関節リウマチに対するインフリキシマブ強化療法.2018

    • Author(s)
      秋山雄次,高松真裕子,和田琢,吉田佳弘,鮫島辰美,神津教倫,横田和浩,荒木靖人,梶山浩,佐藤浩二郎,舟久保ゆう,三村俊英
    • Organizer
      第62回日本リウマチ学会総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] IgG4関連血管病変に対するステロイドの有効性.2018

    • Author(s)
      進藤靖史,中嶋京一,相崎良美,立花秀介,吉田佳弘,横田和浩,秋山雄次,三村俊英
    • Organizer
      第62回日本リウマチ学会総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 再発性多発軟骨炎の寛解維持療法中に髄膜脳炎を発症した一例.2018

    • Author(s)
      野澤祥吾,横田和浩,立花秀介,三宅高史,三宅晃史,山元敏正,三村俊英
    • Organizer
      第62回日本リウマチ学会総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Presence of RANK-Osteoclast-like Cells in the Bone of Patients with Rheumatoid Arthritis.2018

    • Author(s)
      Yokota, K., Tanaka, S., Sato, K., Aizaki, Y., Oda, H., Mimura, T
    • Organizer
      第62回日本リウマチ学会総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 関節リウマチ患者骨組織における破骨細胞様細胞(osteoclast-likecells;OLCs)の同定.2018

    • Author(s)
      横田和浩,田中伸哉,関川三四子,相崎良美,佐藤浩二郎,織田弘美,三村 俊英
    • Organizer
      第4回日本骨免疫学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 骨免疫の基礎と臨床2018

    • Author(s)
      三村俊英
    • Organizer
      第46回日本臨床免疫学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 関節リウマチ患者末梢血単核球における破骨細胞および破骨細胞様細胞の分化誘導能の解析.2018

    • Author(s)
      横田和浩,田中伸哉,関川三四子,相崎良美,佐藤浩二郎,織田弘美,三村俊英
    • Organizer
      第46回日本臨床免疫学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Histone lysine methylation and STAT3 differentially regulate constitutive and IL-6-induced MMP gene activation in rheumatoid arthritis synovial fibroblasts2017

    • Author(s)
      Araki Y, Mimura T
    • Organizer
      Keystone symposia, Epigenetics and human disease
    • Place of Presentation
      Seattle Washigton, USA
    • Year and Date
      2017-01-30
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Histone lysine methylation and STAT3 differentially regulate constitutive and IL-6-induced MMP gene activation in rheumatoid arthritis synovial fibroblasts2017

    • Author(s)
      Araki Y, Mimura T
    • Organizer
      Keystone symposia
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] A novel hierarchical relationship between interleukin-17A and interferon-alpha is indicated by analysis of multiple cytokines in the serum of Adult-Onset Still’s disease and Behçet’s disease2017

    • Author(s)
      K.Sato, Y.Aizaki, Y.Araki, T.Mimura
    • Organizer
      EULAR 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 関節リウマチ滑膜線維芽細胞におけるヒストンH3リシン4メチル基転移酵素によるケモカイン遺伝子転写制御2017

    • Author(s)
      荒木靖人, 相崎良美,横田和浩,梶山浩,舟久保ゆう,佐藤浩二郎,織田弘美,三村俊英
    • Organizer
      第61回日本リウマチ学会総会・学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] ベーチェット病患者γδT細胞におけるヒストンメチル化の解析2017

    • Author(s)
      相崎良美,荒木靖人,佐藤浩二郎,横田和浩,三村俊英
    • Organizer
      第61回日本リウマチ学会総会・学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Histone lysine methylation and STAT3 differentially regulate constitutive and IL-6-induced MMPs gene activation in rheumatoid arthritis synovial fibroblasts2016

    • Author(s)
      Y. Araki, T.T. Wada, Y. Aizaki, K. Sato T. Mimura
    • Organizer
      第45回日本免疫学会総会・学術集会
    • Place of Presentation
      沖縄コンベンションセンター ラグナガーデンホテル
    • Year and Date
      2016-12-06
    • Related Report
      2016 Research-status Report
  • [Presentation] Histone Lysine Methylation and STAT3 Differntially Regulate Constitutive and IL-6-Induced MMPs Gene Activation in Rheumatoid Arthritis Synovial Fibroblasts2016

    • Author(s)
      Yasuto Araki, Takuma Tsuzuki Wada, Yoshimi Aizaki, Kazuhiro Yokota, Hiroshi Kajiyama, Yu Funakubo Asanuma, Kojiro Sato, Hiromi Oda, Toshihide Mimura
    • Organizer
      2016 ACR/ARHP Annual Meeting
    • Place of Presentation
      Washington D.C., USA
    • Year and Date
      2016-11-14
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Histone Methylation in γδ T Cells As a Biomarker of Bechet's Disease Activity2016

    • Author(s)
      Yoshimi Aizaki, Yasuto Araki, Kojiro Sato, Kazuhiro Yokota, Toshihide Mimura
    • Organizer
      2016 ACR/ARHP Annual Meeting
    • Place of Presentation
      Washington D.C., USA
    • Year and Date
      2016-11-13
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 関節リウマチ滑膜線維芽細胞におけるヒストンメチル化とSTAT3によるIL-6誘導性MMP遺伝子活性化2016

    • Author(s)
      荒木靖人,和田琢,相崎良美,佐藤浩二郎,金潤澤,織田弘美,三村俊英
    • Organizer
      関節リウマチ滑膜線維芽細胞におけるヒストンメチル化とSTAT3によるIL-6誘導性MMP遺伝子活性化
    • Place of Presentation
      ホテルモントレ沖縄スパ&リゾート
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
  • [Presentation] Altered profiles of histone lysine Methylation affect MMP gene transcription in rheumatoid arthritis synovial fibroblasts2016

    • Author(s)
      Y.Araki, T.T.Wada, Y.Aizaki, H.Kajiyama, K.Yokota, K.Sato, Y.F.Asanuma, Y.-T.Kim, H.Oda, T.Mimura
    • Organizer
      EULAR 2016
    • Place of Presentation
      London, UK
    • Year and Date
      2016-06-10
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] The epigenetic mechanism of constitutive and IL-6-induced MMP gene activation in rheumatoid arthritis synovial fibroblasts2016

    • Author(s)
      Yasuto Araki, Takuma Tsuzuki Wada, Yoshimi Aizaki, Hiroshi Kajiyama, Kazuhiro Yokota, Kojiro Sato, Yu Funakubo Asanuma, Yoon-Taek Kim, Hiromi Oda, Toshihide Mimura
    • Organizer
      第60回日本リウマチ学会総会・学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-04-22
    • Related Report
      2016 Research-status Report
  • [Presentation] ベーチェット病患者末梢血白血球におけるヒストンメチル化の解析2016

    • Author(s)
      相崎良美,荒木靖人,三村俊英
    • Organizer
      第60回日本リウマチ学会総会・学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-04-21
    • Related Report
      2016 Research-status Report
  • [Book] 日常診療に活かす診療ガイドライン2018

    • Author(s)
      三村俊英
    • Total Pages
      1064
    • Publisher
      メディカルレビュー社
    • Related Report
      2018 Annual Research Report
  • [Book] Epigenetics in Human Disease, 2nd edition2018

    • Author(s)
      Araki, Y., Mimura, T
    • Total Pages
      1110
    • Publisher
      Elsevie
    • Related Report
      2018 Annual Research Report
  • [Book] 内科学(第11版) 【机上版】2017

    • Author(s)
      矢﨑義雄、三村俊英
    • Total Pages
      2534
    • Publisher
      朝倉書店
    • ISBN
      9784254322705
    • Related Report
      2017 Research-status Report
  • [Book] 1336専門家による私の治療 2017-18年度版2017

    • Author(s)
      猿田享男、北村惣一郎、三村俊英
    • Total Pages
      1776
    • Publisher
      日本医事新報社
    • ISBN
      9784784946501
    • Related Report
      2017 Research-status Report
  • [Book] 臨床雑誌内科<月刊> 119巻2号2017

    • Author(s)
      三村俊英
    • Total Pages
      200
    • Publisher
      南江堂
    • Related Report
      2017 Research-status Report
  • [Book] 分子リウマチ治療 10巻1号2017

    • Author(s)
      三村俊英
    • Total Pages
      60
    • Publisher
      先端医学社
    • Related Report
      2017 Research-status Report
  • [Book] 成人スチル病診療ガイドライン2017年版2017

    • Author(s)
      三村俊英
    • Total Pages
      100
    • Publisher
      診断と治療社
    • Related Report
      2017 Research-status Report
  • [Book] 今日の治療指針2016年版2016

    • Author(s)
      三村俊英
    • Total Pages
      2116
    • Publisher
      医学書院
    • Related Report
      2016 Research-status Report
  • [Book] 診療ガイドラインUP-TO-DATE2016-20172016

    • Author(s)
      三村俊英
    • Total Pages
      968
    • Publisher
      メディカルレビュー社
    • Related Report
      2016 Research-status Report
  • [Book] 膠原病・リウマチ・アレルギー研修ノート2016

    • Author(s)
      三村俊英
    • Total Pages
      608
    • Publisher
      診断と治療社
    • Related Report
      2016 Research-status Report
  • [Remarks]

    • URL

      http://www.saitama-med.ac.jp/uinfo/riumachi/gyoseki2N.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] 埼玉医科大学リウマチ膠原病科 業績

    • URL

      http://www.saitama-med.ac.jp/uinfo/riumachi/gyoseki2N.html

    • Related Report
      2017 Research-status Report
  • [Remarks] 埼玉医科大学リウマチ膠原病科ホームページ

    • URL

      http://www.saitama-med.ac.jp/uinfo/riumachi/index.html

    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

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