Examination of role of neutrophil NETs in collagen disease and application to treatment
| Project/Area Number |
16K09913
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | Kurume University |
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Principal Investigator |
Ida Hiroaki 久留米大学, 医学部, 教授 (60363496)
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| Co-Investigator(Kenkyū-buntansha) |
海江田 信二郎 久留米大学, 医学部, 講師 (20330798)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | NETs / 好中球 / iPS細胞 / 膠原病 |
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| Outline of Final Research Achievements |
NETs, which are chromatin nets excreted from activated neutrophils, contain many intracellular component proteins, and not only bactericidal activity other than bacterial capture, but also thrombus formation, cancer metastasis, and the onset of collagen disease. It also plays a major role in autoantibody production. As a whole, NETs have an adverse effect on each disease except for bactericidal activity. In this study, iPS cells were established in 1 RA patient, 1 adult-onset Still's disease patient, and 5 familial Mediterranean fever patients. PMA addition and NETs were detected in normal human iPS cell-derived neutrophils. Addition of colchicine failed to inhibit NETs production.
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| Academic Significance and Societal Importance of the Research Achievements |
膠原病疾患、自己炎症性疾患において、NETsの構成成分の内容、NETsの量、刺激に対する反応の違いが各疾患で異なり、病変局所のみならず、全身症状にも影響を与え、病態形成に重要な役割を果たしている可能性が高い。好中球は寿命が短く解析が難しい細胞であるが、iPS細胞より誘導した好中球は比較的寿命が長いため、解析が行いやすい。コルヒチンでNETs産生が阻害できないことから、今後、NETs産生阻害薬の開発が望まれる。
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Successful Treatment of Rapidly Progressive Unclassifiable Idiopathic Interstitial Pneumonia with Anti-melanoma Differentiation-associated Gene-5 Antibody by Intensive Immunosuppressive Therapy2018
Author(s)
Koga T, Kaieda S, Okamoto M, Masuda K, Fujimoto K, Sakamoto S, Nakamura M, Tominaga M, Kawayama T, Fujimoto K, Hoshino T, Ida H.
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Journal Title
Internal Medicine
Volume: 57
Issue: 7
Pages: 1039-1043
DOI
NAID
ISSN
0918-2918, 1349-7235
Related Report
Peer Reviewed / Open Access
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[Journal Article] Association of anti-aminoacyl-transfer RNA synthetase antibody and anti-melanoma differentiation-associated gene 5 antibody with the therapeutic response of polymyositis/dermatomyositis-associated interstitial lung disease.2017
Author(s)
Yoshida N, Okamoto M, Kaieda S, Fujimoto K, Ebata T, Tajiri M, Nakamura M, Tominaga M, Wakasugi D, Kawayama T, Kuwana M, Mimori T, Ida H, Hoshino T
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Journal Title
Respir Investig.
Volume: 55(1)
Issue: 1
Pages: 24-32
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Clinical and Genetic Features of Patients With TNFRSF1A Variants in Japan: Findings of a Nationwide Survey2016
Author(s)
Ueda, N. Ida, H. Washio, M. Miyahara, H. Tokunaga, S. Tanaka, F. Takahashi, H. Kusuhara, K. Ohmura, K. Nakayama, M. Ohara, O. Nishikomori, R. Minota, S. Takei, S. Fujii, T. Ishigatsubo, Y. Tsukamoto, H. Tahira, T. Horiuchi, T.
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Journal Title
Arthritis Rheumatol
Volume: 68
Issue: 11
Pages: 2760-2771
DOI
Related Report
Peer Reviewed / Open Access
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