Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Outline of Final Research Achievements |
CD4+CD25-LAG3+ regulatory T cells produce a large amount of IL-10 and TGF-β3, and effectively suppress humoral immune responses. However, the mechanisms behind the inhibitory cytokine synergy mediated by IL-10 and TGF-β3 are unclear. In this study, we revealed that IL-10 and TGF-β3 synergistically regulate humoral immunity via modulating mTORC1 signaling in B cells. These findings indicate that the cytokine combination therapy with IL-10 and TGF-β3 might be an effective approach for the treatment of autoimmune diseases.
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