| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Outline of Final Research Achievements |
We recently identified CD200+PD-1+CXCR5-CD4+T cells(peripheral helper T (TPH) cells) that promotes B cell differentiation and antibody production in autoimmune mouse models. Peripheral blood mononuclear cells collected from rheumatoid arthritis, lupus and ANCA-associated vasculitis patients and healthy individuals were analysed. TPH cells were identified as CD200+PD-1+CXCR5-CD4+T cells. Circulating TPH cells were increased in the peripheral blood of rheumatoid arthritis, lupus and ANCA-associated vasculitis patients compared with controls. TPH cells might be a novel therapeutic target in autoantibody-producing autoimmune diseases.
|
