CD200+ peripheral B-helper T cells in autoimmune diseases
Project/Area Number |
16K09919
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Collagenous pathology/Allergology
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Research Institution | St. Marianna University School of Medicine (2017-2018) Tokyo Medical and Dental University (2016) |
Principal Investigator |
Kawahata Kimito 聖マリアンナ医科大学, 医学部, 教授 (70334406)
|
Project Period (FY) |
2016-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | T細胞 / 胸腺 / 免疫学的寛容 / 内科 / 免疫学 |
Outline of Final Research Achievements |
We recently identified CD200+PD-1+CXCR5-CD4+T cells(peripheral helper T (TPH) cells) that promotes B cell differentiation and antibody production in autoimmune mouse models. Peripheral blood mononuclear cells collected from rheumatoid arthritis, lupus and ANCA-associated vasculitis patients and healthy individuals were analysed. TPH cells were identified as CD200+PD-1+CXCR5-CD4+T cells. Circulating TPH cells were increased in the peripheral blood of rheumatoid arthritis, lupus and ANCA-associated vasculitis patients compared with controls. TPH cells might be a novel therapeutic target in autoantibody-producing autoimmune diseases.
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Academic Significance and Societal Importance of the Research Achievements |
膠原病治療は現在でもステロイド治療が中心であり、現在の生物学的製剤では十分な効果が得られていないことから、新たな治療標的が必要とされている。本研究は、自己抗体産生を認める複数の膠原病で健常者ではほとんど認めないCD200+TPH細胞を同定することができたことより、選択的治療に際し有用な成果であると考える。また、この細胞群はPD-1が陽性であり自己免疫に関わることから、抗PD-1抗体を中心とした免疫チェックポイント阻害薬の副作用である免疫関連有害事象への関りも推察され、この細胞群の同定の意義は大きい。さらに、基礎免疫学においても自己反応性T細胞の分化の観点からも重要な知見を今後与えると考える。
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Report
(4 results)
Research Products
(72 results)
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[Journal Article] A low perfusion-metabolic mismatch in 99m Tl and 123 I-BMIPP scintigraphy predicts poor prognosis in systemic sclerosis patients with asymptomatic cardiac involvement.2019
Author(s)
Iida H, Hanaoka H, Okada Y, Kiyokawa T, Takakuwa Y, Yamada H, Okazaki T, Ozaki S, Yamaguchi K, Nakajima Y, Kawahata K.
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Journal Title
International journal of Rheumatic diseases
Volume: -
Issue: 6
Pages: 1008-1015
DOI
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Peer Reviewed
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[Journal Article] Effects of iguratimod on protein profiles of chondrosarcoma cells.2017
Author(s)
Ooka S, Kurokawa S M, Yokoyama M, Arito M, Sato T, Sato M, Takakuwa Y, Omoteyama K, Suematsu N, Kawahata K, Kato T.
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Journal Title
Integrative Molecular Medicine
Volume: 4(6)
Pages: 1-8
Related Report
Peer Reviewed
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[Journal Article] Intestinal microbiota link lymphopenia to murine autoimmunity via PD-1+CXCR5-/dim B-helper T cell induction.2017
Author(s)
Toshiki E, Kawahata K, Kanzaki T, Imamura M, Michishita K, Akahira L, Bannai E, Kimura Y, Satoh T, Yoshikawa N, Uematsu S, Tanaka H. Yamamoto K.
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Journal Title
SCIENTIFIC REPORTS
Volume: 7
Pages: 46037-46037
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Peer Reviewed
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[Journal Article] L, Bannai E, Yoshikawa N, Kimura Y, Satoh T, Uematsu S, Tanaka H, Yamamoto K. Intestinal microbiota link lymphopenia to murine autoimmunity via PD-1(+)CXCR5(-/dim) B-helper T cell induction.2017
Author(s)
Eri T, Kawahata K, Kanzaki T, Imamura M, Michishita K, Akahira L, Bannai E, Yoshikawa N, Kimura Y, Satoh T, Uematsu S, Tanaka H, Yamamoto K.
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Journal Title
Scientific Reports
Volume: 7
Issue: 1
Pages: 1-17
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Early response predicts sustained response to tocilizumab switched from abatacept.2018
Author(s)
Ando Takayasu, Suzuki Takeshi, Ooka Seidou, Nagahuchi Hiroko, Yamasaki Yoshioki, Imamura Mitsuru, Tonooka Kumiko, Takakuwa Yukiko, Kiyokawa Tomohumi, Matsusita Hiromi, Ishimori Kana, Fujimoto Hisae, Shinagawa Shoshi, Uchida Marina, Asari Yusa, Iida Harunobu, Suzuki Kanako, Kawahata Kimito.
Organizer
APLAR 2018
Related Report
Int'l Joint Research
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[Presentation] 実臨床におけるトシリズマブの関節リウマチ患者に対する有効性予測因子の解析2018
Author(s)
安藤貴泰, 鈴木豪, 飯田春信, 品川尚志, 松下広美, 清川智史, 水島万智子, 高桑由希子, 殿岡久美子, 花岡洋成, 山崎宜興, 大岡正道, 永渕裕子, 岡崎貴裕, 尾崎承一, 川畑仁人.
Organizer
第62回リウマチ学会総会・学術集会
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[Presentation] 膠原病が疑われたが,血管内リンパ腫(IVL)と判明した2例2018
Author(s)
品川尚志, 木村未祐奈, 岡崎貴裕, 飯田春信, 安藤貴泰, 内田麻理奈, 松下広美, 清川智史, 高桑由希子, 殿岡久美子, 花岡洋成, 山崎宜興, 大岡正道, 川畑仁人.
Organizer
第62回リウマチ学会総会・学術集会
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[Presentation] イグラチモドが軟骨肉腫細胞の蛋白質プロファイルに与える影響.2018
Author(s)
佐藤利行, 佐藤政秋, 横山倫代, 高桑由希子, 大岡正道, 表山和樹, 有戸光美, 末松直也, 川畑仁人, 加藤智啓, 黒川真奈絵.
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第91回日本生化学会大会,
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[Presentation] 生物学的製剤非ナイーブ関節リウマチ症例におけるトシリズマブ有効性予測因子の検討.2018
Author(s)
安藤貴泰, 鈴木豪, 大岡正道, 永渕裕子, 山崎宜興, 今村充, 殿岡久美子, 高桑由希子, 清川智史, 松下広美, 石森加奈, 藤本久絵, 川畑仁人.
Organizer
第33回日本臨床リウマチ学会
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