Allergen analysis of pollen-food allergy syndrome and development of the new allergen-specific IgE test
| Project/Area Number |
16K09920
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Collagenous pathology/Allergology
|
|---|
| Research Institution | Shimane University |
|---|
Principal Investigator |
Morita Eishin 島根大学, 学術研究院医学・看護学系, 教授 (90182237)
|
|---|
| Research Collaborator |
Ogino Ryohei
|
|---|
| Project Period (FY) |
2016-04-01 – 2019-03-31
|
| Project Status |
Completed (Fiscal Year 2018)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 小麦アレルギー / イネ科花粉症 / 花粉ー食物アレルギー症候群 / 抗原特異的IgE検査 / CAP-FEIA / ペルオキシターゼI / 抗原特異的IgE / 小麦アレルゲン / チオールレダクターゼ / ペルオキシダーゼI / 口腔アレルギー症候群 / 花粉-食物アレルギー症候群 / イネ科花粉 / アレルギー / 花粉症 / 食物アレルギー |
|---|
| Outline of Final Research Achievements |
We have identified peroxidase I as a causative allergen for wheat-dependent exercise-induced anaphylaxis developed as pollen food allergy syndrome(PFAS-WDEIA) due to cross-reaction between wheat proteins and grass pollen allergens. The purpose of this study is to establish peroxidase I-specific IgE test.Serum were obtained from 6 patients with PFAS-WDEIA, 62 patients with other food allergies. Peroxidase I was purified upon chromatography steps, and peroxidase I-specific IgE test was established by CAP-FEIA system. Sensitivity of peroxidase I-specific IgE test was 50% and its specificity was 100%.
Wheat peroxidase I-specific IgE test is useful to identify patients with wheat-dependent exercise-induced anaphylaxis developed by sensitization to grass pollen.
|
| Academic Significance and Societal Importance of the Research Achievements |
本研究にて確立されたperoxidase I特異的IgE検査は、イネ科花粉症にみられる小麦アレルギーの診断に有用です。今後、保険適用されれば、一般医療施設で小麦アレルギーの診断精度が時向上することになります。
|
Report
(4 results)
Research Products
(31 results)
