Detection of human TIM-4 on autoimmune and allergic diseases
Project/Area Number |
16K09924
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Collagenous pathology/Allergology
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Research Institution | Juntendo University |
Principal Investigator |
Akiba Hisaya 順天堂大学, 医学(系)研究科(研究院), 准教授 (60338316)
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Co-Investigator(Renkei-kenkyūsha) |
HARADA norihiro 順天堂大学, 医学部, 准教授 (10465065)
ABE yoshiyuki 順天堂大学, 医学部, 助教 (10647027)
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Project Period (FY) |
2016-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 免疫 / アレルギー / ぜんそく / 炎症 / 診断薬 / 免疫学 / 喘息 / アレルギー・ぜんそく |
Outline of Final Research Achievements |
T cell immunoglobulin and mucin domain (TIM)-4 plays essential roles in macrophage homeostasis. We have previously detected a soluble form of the extracellular domain of TIM-4 (sTIM-4) generated by proteolytic cleavage of mouse macrophages. sTIM-4 induced proinflammatory cytokine production by naive and IgE-stimulated mast cells. Thus, we measured the concentrations of sTIM-4 in patients with asthma in evaluated 125 adult patients with mild to severe asthma. The serum sTIM-4 levels were significantly higher in the asthmatic patients with step 5 treatment by Global Initiative for Asthma (GINA) as compared with the patients with GINA step 1 to 4 treatment. The data suggest that serum sTIM-4 may be associated with asthma severity and may have the potential to be used as biomarker in asthma.
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Academic Significance and Societal Importance of the Research Achievements |
遊離型TIM-4は多種の炎症性サイトカイン産生の誘導に働く。現在、TNF-αなど個々の炎症性サイトカインを標的にした抗体医薬品は実用されているが、多種の炎症性サイトカイン産生を総合的に根本から抑制することが可能になれば、個々の抗サイトカイン抗体療法に抵抗性を示す患者さんの治療に繋がると考えている。また抗TIM-4抗体による抗炎症作用は、喘息に留まらず、他の難治性慢性炎症疾患の新たな治療ターゲット分子になる可能性がある。また遊離型TIM-4は、補助診断あるいは治療効果や予後予測に際して有用なバイオマーカーになる可能性がある。
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] OX40L blockade protects against inflammation-driven fibrosis.2016
Author(s)
Elhai M, Avouac J, Hoffmann-Vold AM, Ruzehaji N, Amiar O, Ruiz B, Brahiti H, Ponsoye M, Frechet M, Burgevin A, Pezet S, Sadoine J, Guilbert T, Nicco C, Akiba H, Heissmeyer V, Subramaniam A, Resnick R, Molberg O, Kahan A, Chiocchia G, Allanore Y.
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Journal Title
Proc Natl Acad Sci USA
Volume: 113
Issue: 27
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] Circulating levels of tenascin-C as type 2 biomarkers in the patients with asthma2018
Author(s)
M. Asaji, N. Harada, S. Harada, A. Ishimori, Y. Katsura, Y. Itoigawa, K. Matsuno, F. Makino, J. Ito, J. Ono, K. Tobino, H. Akiba, R. Atsuta, K. Izuhara, K. Takahashi
Organizer
第58回日本呼吸器学会会学術講演会
Related Report
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[Presentation] Chitin Induced Airway Inflammation and Production of Prostaglandin E22018
Author(s)
T. Takeshige, N. Harada, K. Matsuno, A. Ishimori, Y. Tanabe, H. Sasano, A. Nakamura, S. Harada, Y. Katsura, F. Makino, J. Ito, R. Atsuta, H. Akiba, K. Takahashi
Organizer
第58回日本呼吸器学会会学術講演会
Related Report
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[Presentation] The effect of mepolizumab treatment in patients with severe asthma2017
Author(s)
Yuuki Sandhu, Norihiro Harada, Kei Matsuno, Sonoko Harada, Tomohito Takeshige, Ayako Ishimori, Yoko Katsura, Fumihiko Makino, Jun Ito, Ryo Atsuta, Hisaya Akiba, Kazuhisa Takahashi
Organizer
The 22nd Congress of the Asian Pacific Society of Respirology
Related Report
Int'l Joint Research
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[Presentation] Serum tenascin-C levels in patients with asthma2017
Author(s)
Norihiro Harada, Mina Asaji, Sonoko Harada, Ayako Ishimori, Yoko Katsura, Yukinari Itoigawa, Kei Matsuno, Fumihiko Makino, Jun Ito, Junya Ono, Kazunori Tobino, Hisaya Akiba, Ryo Atsuta1, Kenji Izuhara, and Kazuhisa Takahashi
Organizer
The 22nd Congress of the Asian Pacific Society of Respirology
Related Report
Int'l Joint Research
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[Presentation] TWEAK and TGF-β induced chemokine production in human bronchial epithelial cells during epithelial mesenchymal transition2017
Author(s)
Kei Matsuno, Norihiro Harada, Tomohito Takeshige, Ayako Ishimori, Yuki Tanabe, Hitoshi Sasano, Ai Nakamura, Yoko Katsura, Fumihiko Makino, Jun Ito, Ryo Atsuta, Hisaya Akiba, Kazuhisa Takahashi
Organizer
The 22nd Congress of the Asian Pacific Society of Respirology
Related Report
Int'l Joint Research
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[Presentation] Chitin induced airway inflammation and production of prostaglandin E22017
Author(s)
Tomohito Takeshige, Norihiro Harada, Kei Matsuno, Ayako Ishimori, Yuki Tanabe, Hitoshi Sasano, Ai Nakamura, Sonoko Harada, Yoko Katsura, Fumihiko Makino, Jun Ito, Ryo Atsuta, Hisaya Akiba, Kazuhisa Takahashi
Organizer
The 22nd Congress of the Asian Pacific Society of Respirology
Related Report
Int'l Joint Research
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[Presentation] 上皮間葉転換が誘導された気道上皮細胞におけるケモカイン産生2017
Author(s)
松野圭, 原田紀宏, 石森絢子, 竹重智仁, 桂蓉子, 三道ユウキ, 中村愛, 笹野仁史, 田辺悠記, 牧野文彦, 伊藤潤, 熱田了, 秋葉久弥, 高橋和久
Organizer
第66回日本アレルギー学会学術集会
Related Report
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[Presentation] TWEAK enhances epithelial mesenchymal transition and chemokine production in human bronchial epithelial cells2017
Author(s)
Kei Matsuno, Norihiro Harada, Itoigawa Yukinari, Tomohito Takeshige, Sonoko Harada, Ayako Ishimori, Yuki Tanabe, Yoko Katsura, Fumihiko Makino, Jun Ito, Ryo Atsuta, Hisaya Akiba, Kazuhisa Takahashi
Organizer
第46回日本免疫学会学術集会
Related Report
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[Presentation] OX40L BLOCKADE PROTECTS AGAINST SKIN AND LUNG INFLAMMATION-DRIVEN FIBROSIS2016
Author(s)
M. Elhai, J. Avouac, A.-M. Hoffmann-Vold, J. Sadoine, T. Guilbert, H. Akiba, V. Heissmeyer, A. Subramaniam, R. Resnick, G. Chiocchia, Y. Allanore
Organizer
欧州リウマチ学会 EULAR 2016
Place of Presentation
London, UK
Year and Date
2016-06-08
Related Report
Int'l Joint Research
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