| Project/Area Number |
16K09942
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
長谷川 直樹 慶應義塾大学, 医学部(信濃町), 教授 (20198724)
下田 将之 慶應義塾大学, 医学部(信濃町), 講師 (70383734)
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| Research Collaborator |
SUGIURA Yuki
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 非結核性抗酸菌症 / 肺MAC症 / 感染症 |
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| Outline of Final Research Achievements |
To investigate the pathophysiology of Mycobacterium avium complex (MAC) pulmonary disease, a nontuberculous mycobacterial infection, we studied the host immune response to a bacterial cell wall lipid, glycopeptidolipid (GPL), as well as the pathogenicity of GPL. We extracted GPL from MAC and assessed its molecular structure by mass spectrometry. Experiments with MAC-infected human macrophages and mice suggested that GPL is involved in the pathophysiology of MAC pulmonary disease.
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| Academic Significance and Societal Importance of the Research Achievements |
日本において、肺NTM症の罹患率は増加の一途をたどっており、肺NTM症の内、肺MAC症が約90％を占めている。しかし、肺MAC症はその病態において依然不明な点が多い、診断が困難かつ、難治性の慢性呼吸器感染症である。本研究で、菌細胞壁脂質であるGPLの肺MAC症の病態への関与が示唆されたことから、今後、GPLに着目した精度の高い検査法や治療効果の高い薬物が開発され、より良い肺MAC症診療が可能になることが期待される。
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