An applicable study of tricin for prevention and treatment of alphaherpesviral infections diseases
| Project/Area Number |
16K09948
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Hokuriku University |
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Principal Investigator |
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| Project Period (FY) |
2016-10-21 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 水痘帯状疱疹ウイルス / 単純ヘルペスウイルス / tricin / acyclovir / 急性網膜壊死 / 網膜ミュラー細胞 / ケモカイン / マトリックスメタロプロテアーゼ / 水筒帯状疱疹ウイルス / Tricin / 再活性化 / 母子感染 |
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| Outline of Final Research Achievements |
Alphaherpesviruses such as varicella-zoster virus (VZV) and herpes simplex virus (HSV) occasionally cause severe infectious diseases like acute retinal necrosis (ARN) for which acyclovir (ACV) is not enough effective. In the present study, I addressed the applicable possibility that a flavonoid, tricin, exhibiting a potent antiviral activity could be an alternative or supportive drug of ACV. I found human retinal Muller cell line as a in vitro model of pathogenesis of ARN in which production of several inflammatory factors including IL-8 and MMP-13 was increased in response to VZV infection. Furthermore, it was demonstrated that tricin showed stronger antiviral and antiinflammatory effects than ACV in the infected cells. These results suggest that tricin could be a promising candidate of an alternative or supportive drug of ACV in the treatment of ARN.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により、これまでに不明であったARNの発症機序の一端として、ウイルスに感染した網膜Muller細胞から産生されるケモカインやプロテアーゼの関与の可能性が示唆された。またACVでは同細胞でのウイルス増殖を完全に抑制することはできなかった。このことはACV単剤ではARNの進行を止められないことと符合する。さらに天然のフラボノイドであるtricinが、ACVよりも強い抗ウイルス効果・抗炎症効果を網膜Muller細胞で示すことを明らかにした。このことは、現在のARNの治療成績を改善する新たな治療薬候補となる可能性があり、臨床上大きな意義を持つ成果といえる。
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] An in silico-designed flavone derivative, 6-fluoro-4′-hydroxy-3′,5′-dimethoxyflavone, has a greater anti-human cytomegalovirus effect than ganciclovir in infected cells2018
Author(s)
Kazuhiro J. Fujimoto, Daiki Nema, Masayuki Ninomiya, Mamoru Koketsu, Hidetaka Sadanari, Masaya Takemoto, Tohru Daikoku, Tsugiya Murayama
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Journal Title
Antivir. Res.
Volume: 154
Pages: 10-16
DOI
Related Report
Peer Reviewed / Open Access
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