| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
Our results show that the upregulation of multiple co-expression modules containing genes located outside of the standard 7q11.23 deletion region may significantly contribute to the intermediate and highly variable Williams syndrome phenotypes.The effects of the glial cell activation-mediated mRNA/miRNA regulatory network provide novel insight into the biological mechanisms underlying Williams syndrome neuropsychiatric phenotypes.The downregulation of one miRNA module appears to have significant consequences on the transcriptome, leading to the upregulation of three mRNA modules, all of which include genes that are dispersed throughout the genome.
To our knowledge, this is the first time that the dysregulated mRNA and miRNA transcriptomic networks have been broadly evaluated in association with the complex phenotypes observed in Williams syndrome patients.
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