Interaction between nuclear receptors and docosahexaenoic acid concerning the regulation of lipid levels of breast milk
Project/Area Number |
16K09976
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pediatrics
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Research Institution | Osaka Medical College |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
玉井 浩 大阪医科大学, 医学部, 教授 (30179874)
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Project Period (FY) |
2016-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | 母乳 / 核内受容体 / ドコサヘキサエン酸 |
Outline of Final Research Achievements |
Nutrition of breast-feeding is the most appropriate of all available milks for human infants. Long-chain n-3 polyunsaturated fatty acid, docosahexaenoic acid is main fatty acid contained in cell menbranes of central nerve tissues, and has inportant role for neurological development during fetus and infant. In the study, we investigated the relationship between docosahexaenoic acid and nuclear receptors siganalling during laction. The present study demonstrataed that docosahexaenoic acid may affect the expression of lipid metabolism related genes regulated by transcriptional nuclear receptors in mammary glands during lactation.
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Academic Significance and Societal Importance of the Research Achievements |
ドコサヘキサエン酸は胎児から乳児期における神経発達に重要な役割を果たす。また、母乳中脂質は乳児のエネルギーの維持に非常に重要である。我々は、ドコサヘキサエン酸が授乳期の母乳中脂質濃度調節に関与する否かを検討することで、乳腺組織におけるドコサヘキサエン酸の新たな作用を見いだすかもしれない。また、乳児の母乳栄養に有用な情報を提供することが期待される。
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Evaluation of uric acid levels, thyroid function, and anthropometric parameters in Japanese children with Down syndrome2017
Author(s)
Niegawa T, Takitani K, Takaya R, Ishiro M, Kuroyanagi Y, Okasora K, Minami Y, Matsuda T, Tamai H.
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Journal Title
Journal of Clinical Biochemistry and Nutrition
Volume: 61
Issue: 2
Pages: 146-152
DOI
NAID
ISSN
0912-0009, 1880-5086
Related Report
Peer Reviewed
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