Interaction between nuclear receptors and docosahexaenoic acid concerning the regulation of lipid levels of breast milk

• Project/Area Number: 16K09976
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Osaka Medical College
• Principal Investigator: TAKITANI Kimitaka 大阪医科大学, 医学部, 教授 (80319540)
• Co-Investigator(Kenkyū-buntansha): 玉井 浩 大阪医科大学, 医学部, 教授 (30179874)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 母乳 / 核内受容体 / ドコサヘキサエン酸

Outline of Final Research Achievements

Nutrition of breast-feeding is the most appropriate of all available milks for human infants. Long-chain n-3 polyunsaturated fatty acid, docosahexaenoic acid is main fatty acid contained in cell menbranes of central nerve tissues, and has inportant role for neurological development　during fetus and infant. In the study, we investigated the relationship between docosahexaenoic acid and nuclear receptors siganalling during laction. The present study demonstrataed that docosahexaenoic acid may affect the expression of lipid metabolism related genes regulated by transcriptional nuclear receptors in mammary glands during lactation.

Academic Significance and Societal Importance of the Research Achievements

ドコサヘキサエン酸は胎児から乳児期における神経発達に重要な役割を果たす。また、母乳中脂質は乳児のエネルギーの維持に非常に重要である。我々は、ドコサヘキサエン酸が授乳期の母乳中脂質濃度調節に関与する否かを検討することで、乳腺組織におけるドコサヘキサエン酸の新たな作用を見いだすかもしれない。また、乳児の母乳栄養に有用な情報を提供することが期待される。

Research Products

• [Journal Article] Attitudes of pediatricians toward Children’s consumption of ionic beverages (2018)
  • Author(s): Okumura Akihisa、On behalf of the Committee on Pediatric Nutrition of The Japanese Pediatric Society、Ida Shinobu、Mori Masaaki、Shimizu Toshiaki
  • Journal Title: BMC Pediatrics Volume: 18 Issue: 1 Pages: 176-176
  • DOI: 10.1186/s12887-018-1154-3
  • Peer Reviewed / Open Access
• [Journal Article] Altered Expression of Retinol Metabolism-Related Genes in an ANIT-Induced Cholestasis Rat Model. (2018)
  • Author(s): Takitani K, Kishi K, Miyazaki H, Koh M, Tamaki H, Inoue A, Tamai H.
  • Journal Title: Int J Mol Sci. Volume: 19 Issue: 11 Pages: 3337-3337
  • DOI: 10.3390/ijms19113337
  • Peer Reviewed / Open Access
• [Journal Article] Microvascular endothelial function in Japanese early adolescents (2017)
  • Author(s): Odanaka Y, Takitani K, Katayama H, Fujiwara H, Kishi K, Ozaki N, Ashida A, Takaya R, Tamai H.
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 61 Issue: 3 Pages: 228-232
  • DOI: 10.3164/jcbn.17-58
  • NAID: 130006191923
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed
• [Journal Article] Evaluation of uric acid levels, thyroid function, and anthropometric parameters in Japanese children with Down syndrome (2017)
  • Author(s): Niegawa T, Takitani K, Takaya R, Ishiro M, Kuroyanagi Y, Okasora K, Minami Y, Matsuda T, Tamai H.
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 61 Issue: 2 Pages: 146-152
  • DOI: 10.3164/jcbn.17-55
  • NAID: 130006038883
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed
• [Journal Article] Dehydroepiandrosterone alters vitamin E status and prevents lipid peroxidation in vitamin E-deficient rats (2016)
  • Author(s): Miyazaki H, Takitani K, Koh M, Inoue A, Tamai H.
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 58 Issue: 3 Pages: 223-231
  • DOI: 10.3164/jcbn.15-133
  • NAID: 130005149367
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed / Open Access
• [Journal Article] Dehydroepiandrosterone Alters Retinol Status and Expression of the β-Carotene 15,15′-Monooxygenase and Lecithin:Retinol Acyltransferase Genes (2016)
  • Author(s): Takitani K, Miyazaki H, Koh M, Kishi K, Inoue A, Tamai H.
  • Journal Title: Journal of Nutritional Science and Vitaminology Volume: 62 Issue: 1 Pages: 12-18
  • DOI: 10.3177/jnsv.62.12
  • NAID: 130005148613
  • ISSN: 0301-4800, 1881-7742
  • Peer Reviewed / Open Access
• [Presentation] Comparing pharmacokinetics of all-trans retinoic acid between adults and children with acute promyelocytic leukemia. (2018)
  • Author(s): Takitani K, Inoue A, Tamai H.
  • Organizer: 2018 Annual Meeting of the Canadian Society of Pharmacology and Therapeutics.
  • Int'l Joint Research
• [Presentation] Perspectives for nutrition (vitamins and elements) among children in Japan. (2018)
  • Author(s): Takitani K.
  • Organizer: 2018 Autumn Meeting of Taiwan Society of Parenteral Enteral Nutrition
  • Int'l Joint Research / Invited
• [Presentation] Expression of beta-carotene 15, 15’ monooxygenase and alteration of retinol status by dehydroepiandrosterone. (2017)
  • Author(s): Takitani K. Tamai H.
  • Organizer: The International 18th Symposium on Carotenoids
• [Presentation] Dehydroepiandrosterone prevents lipid peroxidation in vitamin E-deficient rats. (2017)
  • Author(s): Takitani K. Tamai H.
  • Organizer: The 8th Joint Meeting of Society for Free Radical Research Australasia and Japan with International Symposium on Coenzyme Q10
• [Presentation] Altered expression of retinol-related proteins and retinol status in streptozotocin-induced type 1 diabetic model rats. (2016)
  • Author(s): Takitani K, Tamai H.
  • Organizer: The Fifth International Conference on Cofactors (ICC-05) and Active Enzyme Molecule 2016
  • Place of Presentation: 宇奈月国際会館（富山県黒部市）
  • Year and Date: 2016-09-04
  • Int'l Joint Research
• [Remarks] 大阪医科大学小児科
  • URL: http://www.osaka-med.ac.jp/deps/ped/index.html