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Immunological mechanism of cerebral white matter lesion in congenital cytomegalovirus infection.

Research Project

Project/Area Number 16K09986
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionShinshu University

Principal Investigator

Inaba Yuji  信州大学, 医学部, 特任教授 (30334890)

Co-Investigator(Kenkyū-buntansha) 本林 光雄  信州大学, 医学部附属病院, 特任研究員 (90747940)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsサイトメガロウイルス / 先天性サイトメガロウイルス感染症 / 大脳白質 / 海馬形成異常 / 遺伝子多型 / 神経発達症 / 海馬回転異常 / ガンシクロビル / 大脳白質病変 / 大脳皮質形成異常 / 自閉スペクトラム症 / 聴覚障害 / 抗ウイルス薬 / 脳神経疾患 / ウィルス
Outline of Final Research Achievements

Congenital cytomegalovirus infection that has increased in recent years cause various complications in the brain, but there are many unknown points about the condition. In this study, neurodevelopmental disorders, cerebral white matter lesion, and hippocampal malrotation were complicated with high rates in this disease. The size of the cerebral white matter lesions was correlated with the intelligence index, but it was not clear about the association between hippocampus lesions and neurodevelopmental disorders. As a result of polymorphic analysis of immune-related genes, the relationship between polymorphism of Toll-like receptors and cytokine genes and the brain lesions was suggested. Intrauterine viral exposure caused a variety of brain lesions, suggesting that the expression involved a gene polymorphism of the immune system.

Academic Significance and Societal Importance of the Research Achievements

様々な症状を呈する先天性サイトメガロウイルス感染症では、中枢神経合併症がその後の患者および家族の生活の質に大きく影響を与える。本研究で明らかにした神経発達症や大脳白質病変、海馬形成異常の頻度の多さ、ならびに免疫関連遺伝子多型との関連により、患者の重症度リスク評価が可能となり、抗ウイルス治療などの治療戦略を検討する一つの指標になると考えられる。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (12 results)

All 2020 2019 2018 2017 2016

All Journal Article (7 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results) Presentation (5 results) (of which Invited: 1 results)

  • [Journal Article] 先天性CMV感染症における神経・発達予後2020

    • Author(s)
      稲葉雄二
    • Journal Title

      日本周産期・新生児医学会雑誌

      Volume: 56

    • Related Report
      2019 Annual Research Report
  • [Journal Article] A rational approach to identifying newborns with hearing loss caused by congenital cytomegalovirus infection by dried blood spot screening.2018

    • Author(s)
      Moteki H, Isaka Y, Inaba Y, Motobayashi M, Nishio SY, Ohira S, Yano T, Iwasaki S, Shiozawa T, Koike K, Usami SI.
    • Journal Title

      Acta Otolaryngol.

      Volume: 1 Issue: 8 Pages: 708-712

    • DOI

      10.1080/00016489.2018.1441545

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Postencephalitic epilepsy secondary to cytomegalovirus encephalitis2018

    • Author(s)
      Nasuno M, Shigemura T, Nakazawa Y, Inaba Y, Motobayashi M
    • Journal Title

      Pediatr Int

      Volume: 60 Issue: 8 Pages: 758-760

    • DOI

      10.1111/ped.13594

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A case of postencephalitic epilepsy secondary to cytomegalovirus encephalitis2018

    • Author(s)
      Mitsuo Motobayashi, Masaru Nasuno, Tomonari Shigemura, Yozo Nakazawa, Yuji Inaba
    • Journal Title

      Pediatrics International

      Volume: 60

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Correlation Between White Matter Lesions and Intelligence Quotient in Patients With Congenital Cytomegalovirus Infection2016

    • Author(s)
      Inaba Y, Motobayashi M, Nishioka M, Kaneko T, Yamauchi S, Kawasaki Y, Shiba N, Nishio SY, Moteki H, Miyagawa M, Takumi Y, Usami S, Koike K
    • Journal Title

      Pediatric Neurology

      Volume: 55 Pages: 52-57

    • DOI

      10.1016/j.pediatrneurol.2015.11.014

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 先天性サイトメガロウイルス感染症 耳鼻咽喉科と連携した神経発達診療2016

    • Author(s)
      稲葉 雄二
    • Journal Title

      小児科

      Volume: 57 Pages: 236-270

    • NAID

      40020762705

    • Related Report
      2016 Research-status Report
  • [Journal Article] 先天性サイトメガロウイルス感染症スクリーニングに関する多施設共同研究結果の検討(第1報)2016

    • Author(s)
      本林 光雄, 稲葉 雄二, 西岡 誠, 川崎 洋一郎, 井坂 友一, 西尾 信哉, 茂木 英明, 大平 哲史, 岩崎 聡, 中村 友彦, 宇佐美 真一
    • Journal Title

      小児耳鼻咽喉科学会雑誌

      Volume: 37 Pages: 29-34

    • NAID

      130005256062

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] 先天性CMV感染症における神経・発達予後2019

    • Author(s)
      稲葉雄二
    • Organizer
      日本周産期・新生児医学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 先天性サイトメガロウイルス感染症の診療の進歩 地域における連携と小児神経科の取り組み2018

    • Author(s)
      稲葉 雄二
    • Organizer
      第60回日本小児神経学会学術集会 シンポジウム
    • Related Report
      2018 Research-status Report
  • [Presentation] 先天性サイトメガロウイルス感染症における海馬形成異常と自閉スペクトラム症の関連2018

    • Author(s)
      夏目 岳典, 那須野 将, 柳沢 俊光, 柴 直子, 本林 光雄, 稲葉 雄二
    • Organizer
      第60回日本小児神経学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] サイトメガロウイルス脳室脳炎後にてんかんを発症した一例2018

    • Author(s)
      那須野 将, 本林 光雄, 大澤 由寛, 森川 愛美, 夏目 岳典, 柳沢 俊光, 稲葉 雄二
    • Organizer
      第60回日本小児神経学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] Autism Spectrum Disorder in Children with Congenital Cytomegalovirus Infection2017

    • Author(s)
      Yuji INABA, Mitsuo MOTOBAYASHI, Manami MORIKAWA, Makoto NISHIOKA, Mitsuho TAKATSUKI
    • Organizer
      14th Asian and Oceanian Congress of Child Neurology
    • Related Report
      2017 Research-status Report 2016 Research-status Report

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Published: 2016-04-21   Modified: 2021-02-19  

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