The application of nanoparticle to epucutaneous immunotherapy for food allergy
| Project/Area Number |
16K10018
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | University of Fukui |
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Principal Investigator |
Ohshima Yusei 福井大学, 学術研究院医学系部門, 教授 (40303391)
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| Research Collaborator |
Makino Akira
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 経皮免疫療法 / ナノ粒子 / アジュバント / 好塩基球 / 食物アレルギー / 経皮感作 / 免疫療法 / マスト細胞 |
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| Outline of Final Research Achievements |
In epicutaneously sensitized mice, suppression of skin inflammation in the antigen-administered site alleviated oral challenge-induced symptoms. The changes in mRNA expression profiles in the skin and intestine suggested that suppression of basophil activation and type 2 cytokine expression in the skin and mast cell activation in the intestine was involved in the alleviation of the symptoms.
Application of OVA-encapsulated nanoparticles, which were made by poly(lactide-co-glycolide), increased serum levels of OVA-specific IgG. Epicutaneous immunotherapy with these nanoparticles tended to suppress symptoms induced by oral challenge of OVA. However, butyrate ester-encapsulated nanoparticles did not show any adjuvant effects.
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| Academic Significance and Societal Importance of the Research Achievements |
アトピー性皮膚炎に伴う食物アレルギーでは、皮膚炎を抑制することが、原因食物の誤食により誘発される症状を軽減させる上で重要であることを明らかにした。また、その免疫学的機序として、皮膚における好塩基球の活性化とタイプ２サイトカインの発現抑制が関与していることを明らかにした。この結果は、原因食物除去だけでなく皮膚炎のコントロールによる好塩基球の活性化抑制が重要であることを示した。
ナノ粒子を用いた免疫療法としては、食物アレルギーの分野では経口投与が考えられているが、ナノ粒子を皮膚に塗布する方法が新たな免疫療法となる可能性が示唆された。
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Report
(4 results)
Research Products
(66 results)
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[Journal Article] Japanese guidelines for food allergy 20172017
Author(s)
Urisu A, Ebisawa M, Ito K, Aihara Y, Ito S, Mayumi M, Kohno Y, Kondo N; Committee for Japanese Pediatric Guideline for Food Allergy.; Japanese Society of Pediatric Allergy and Clinical Immunology.; Japanese Society of Allergology
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Journal Title
Allergology International
Volume: 66
Issue: 2
Pages: 248-264
DOI
NAID
ISSN
1323-8930, 1440-1592
Related Report
Peer Reviewed / Open Access
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