Functional analysis of ORMDL3 related unfolded protein response in childhood-onset bronchial asthma
| Project/Area Number |
16K10053
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | National Center for Child Health and Development |
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Principal Investigator |
FUTAMURA KYOKO 国立研究開発法人国立成育医療研究センター, 免疫アレルギー・感染研究部, (非)研究員 (60596956)
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| Co-Investigator(Kenkyū-buntansha) |
五十嵐 ありさ 国立研究開発法人国立成育医療研究センター, 免疫アレルギー・感染研究部, (非)研究員 (60572998)
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| Research Collaborator |
ORIHARA kanami
MATSUMOTO kenji
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ORMDL3 / 小児発症気管支喘息 / 小胞体ストレス / ウイルス感染 / アレルギー・ぜんそく / 免疫学 |
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| Outline of Final Research Achievements |
In plural genome-wide association studies, the 17th chromosome q12-21 was identified as the locus that had strong correlation with childhood-onset bronchial asthma. ORMDL3 is a dominant candidate for disease susceptibility genes. However, it remains unclear how the gene affected disease condition of bronchial asthma.
In this study, we elucidated the mechanism that ORMDL3 molecules exacerbated bronchial inflammation through unfolded protein response during viral infection.
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| Academic Significance and Societal Importance of the Research Achievements |
本邦では最近数十年の間にアレルギー疾患は急速に一般的な疾病となり、罹患する人口が非常に多くなっており、生活の質の低下や医療費の増大を招くことで社会的に大きな負荷となっている。また幼少期に罹患した場合、その後も症状が持続して重症化することや他のアレルギー疾患が続発する現象が認められることからも、早期の治療介入が望ましい。
今回の研究で私たちは小児早期発症の気管支喘息について、疾患感受性分子ORMDL3の病態に対する作用を明らかにし、将来的には喘息の新規治療につながる可能性を見出した。
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Gene Expression Patterns in Distinct Endoscopic Findings for Eosinophilic Gastritis in Children.2017
Author(s)
Sato M, Shoda T, Shimizu H, Orihara K, Futamura K, Matsuda A, Yamada Y, Irie R, Yoshioka T, Shimizu T, Ohya Y, Nomura I, Matsumoto K, Arai K.
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Journal Title
The Journal of Allergy and Clinical Immunology: In Practice
Volume: 5
Issue: 6
Pages: 1639-1649
DOI
Related Report
Peer Reviewed
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[Journal Article] Gene expression profiling of acute type A aortic dissection combined with in vitro assessment.2017
Author(s)
Kimura N, Futamura K, Arakawa M, Okada N, Emrich F, Okamura H, Sato T, Shudo Y, Koyano TK, Yamaguchi A, Adachi H, Matsuda A, Kawahito K, Matsumoto K, Fischbein MP.
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Journal Title
European Journal of Cardio-Thoracic Surgery
Volume: 52
Issue: 4
Pages: 810-817
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Platelets constitutively express IL-33 protein and modulate eosinophilic airway inflammation2016
Author(s)
Takeda T, Unno H, Morita H, Futamura K, Emi-Sugie M, Arae K, Shoda T, Okada N, Igarashi A, Inoue E, Kitazawa H, Nakae S, Saito H, Matsumoto K, Matsuda A.
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Journal Title
Journal of Allergy and Clinical Immunology
Volume: 138
Pages: 1395-1403
Related Report
Peer Reviewed / Acknowledgement Compliant
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