|Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|Outline of Final Research Achievements
This study was aimed to investigate the role of STAT5B in pediatric idiopathic steroid-sensitive nephrotic syndrome and to reveal the pathophysiology, then to contribute to develop new medicines for this disease.
ChIP-seq technique was applied for this study, using the patients’ paired-peripheral blood mononuclear cells from nephrotic-phase before initiation of steroids and from remission phase without any medication.
Several peaks of binding-sites were detected. The peaks were statistically different between nephrotic-phase and remission-phase. Some of them were the binding sites for vascular permeability, cellular or humoral immunity or lipid metabolism.