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Is genetics a risk factor for clinical kernicterus in preterm infants?

Research Project

Project/Area Number 16K10088
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Embryonic/Neonatal medicine
Research InstitutionShiga University of Medical Science

Principal Investigator

YANAGI TAKAHIDE  滋賀医科大学, 医学部, 助教 (70418755)

Co-Investigator(Kenkyū-buntansha) 荒井 洋  社会医療法人大道会(神経リハビリテーション研究部), 神経リハビリテーション研究部, 研究員 (50501194)
丸尾 良浩  滋賀医科大学, 医学部, 教授 (80314160)
森岡 一朗  神戸大学, 医学研究科, 非常勤講師 (80437467)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsUGT1A1 / 臨床的核黄疸 / 早産児 / 慢性ビリルビン脳症 / 臨床的黄疸 / 未熟児医学 / 核黄疸
Outline of Final Research Achievements

In the current study, we found that a polymorphism of Bilirubin UDP-glucronosyltransferase (UGT1A1) gene is a strong risk factor for prolonged hyperbirlirubinemia and clinical kernicterus in Japanese preterm infants. These findings might be very important keys to prevention of bilirubin brain damage in preterm infants in future.

Academic Significance and Societal Importance of the Research Achievements

本研究において、ビリルビングルクロン酸転移酵素(UGT1A1)遺伝子の多型(UGT1A1*6)が、早産児における遷延性黄疸、および早産児における臨床的核黄疸の、強力な危険因子であることが明らかとなった。現在、早産児の黄疸管理法は確立していないが、今後、臨床的核黄疸を予防するために、これらの危険因子を軸に早産児の黄疸管理を構築していくことが急務である。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (2 results)

All 2018 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Bilirubin Uridine Diphosphate-glucuronosyltransferase Polymorphism as a Risk Factor for Prolonged Hyperbilirubinemia in Japanese Preterm Infants2017

    • Author(s)
      Yanagi Takahide、Nakahara Sayuri、Maruo Yoshihiro
    • Journal Title

      The Journal of Pediatrics

      Volume: 190 Pages: 159-162

    • DOI

      10.1016/j.jpeds.2017.07.014

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] The impact of genetics on kernicterus in preterm infants2018

    • Author(s)
      Takahide Yanagi
    • Organizer
      Pediatric Academic Society Meeting 2018
    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Int'l Joint Research

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

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