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Basic research to prevent intrauterine Cytomegalovirus (CMV) infection and CMV-related hearing loss

Research Project

Project/Area Number 16K10097
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Embryonic/Neonatal medicine
Research InstitutionTohoku Medical and Pharmaceutical University

Principal Investigator

IKUTA Kazufumi  東北医科薬科大学, 医学部, 准教授 (60512184)

Co-Investigator(Kenkyū-buntansha) 小林 敬広  福島県立医科大学, 医学部, 助教 (00708745)
石岡 賢  福島県立医科大学, 医学部, 講師 (50305356)
Research Collaborator SUZUTANI Tatsuo  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsサイトメガロウイルス / 先天感染 / ウイルス / 母子感染
Outline of Final Research Achievements

To clarify the etiology of congenital Cytomegalovirus (CMV) infection, we focused on the role of microRNAs (miRNAs), which are expressed at high levels in placental trophoblasts. We used C19MC, a unique group of primate-specific miRNAs, which are highly expressed in human trophoblasts from the chromosome 19 miRNA cluster. We confirmed the enhanced CMV infection in cells with C19MC-BAC. We also confirmed the possibility of cross-reactivity between myosin VI, which is known to have important role for hearing in cochlea, and CMV antigen.

Academic Significance and Societal Importance of the Research Achievements

先天性CMV感染は全出生の1/300と高頻度で生じている。顕性感染例については平成30年1月から尿を用いたウイルス検出が保険適用となった。米国では患児家族団体の働きにより、リスク新生児を対象としたウイルススクリーニング検査の義務化を可決する州が増えつつある。先天性CMV感染については厚生労働科学研究班や患者会が設立され、予防・治療に関する研究が強く求められている。本研究は胎内CMV感染と難聴の機序解明を行い、先天性CMV感染とその疾患予防に貢献することが目的である。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (21 results)

All 2019 2018 2017 2016

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 3 results) Presentation (15 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Detection of engraftment of donor-derived antibody producing cells in a lung transplant recipient by anti-cytomegalovirus IgG avidity test2019

    • Author(s)
      Koshizuka Tetsuo、Matsuda Yasushi、Suzuki Hirotoshi、Kanno Ryoko、Ikuta Kazufumi、Kobayashi Takahiro、Kondo Takashi、Okada Yoshinori、Suzutani Tatsuo
    • Journal Title

      Transplant Immunology

      Volume: 53 Pages: 34-37

    • DOI

      10.1016/j.trim.2018.12.003

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapid CRISPR/Cas9-Mediated Cloning of Full-Length Epstein-Barr Virus Genomes from Latently Infected Cells2018

    • Author(s)
      Misako Yajima, Kazufumi Ikuta, Teru Kanda
    • Journal Title

      Viruses

      Volume: 10 Issue: 4 Pages: 171-183

    • DOI

      10.3390/v10040171

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Congenital cytomegalovirus infection via a re-infected mother with original antigenic sin: A case report2018

    • Author(s)
      Koshizuka Tetsuo、Toriyabe Kuniaki、Sato Yuko、Ikuta Kazufumi、Ikeda Tomoaki、Suzutani Tatsuo
    • Journal Title

      International Journal of Infectious Diseases

      Volume: 77 Pages: 87-89

    • DOI

      10.1016/j.ijid.2018.10.006

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of herpes simplex virus type 1 UL13 in the induction of SOCS genes, the negative regulator of cytokine signaling2017

    • Author(s)
      Sato Y, Koshizuka T, Ishibashi K, Hashimoto K, Ishioka K, Ikuta K, Yokota S, Fujii N, Suzutani T.
    • Journal Title

      Microbiol Immunol

      Volume: 61 Issue: 5 Pages: 159-167

    • DOI

      10.1111/1348-0421.12483

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Modification of the HCMV-specific IFN-γ release test (QuantiFERON-CMV) and a novel proposal for its application2017

    • Author(s)
      Kobayashi T, Sato J, Ikuta K, Kanno R, Nishiyama K, Koshizuka T, Ishioka K, Suzutani T.
    • Journal Title

      FUKUSHIMA JOURNAL OF MEDICAL SCIENCE

      Volume: 63 Issue: 2 Pages: 64-74

    • DOI

      10.5387/fms.2017-01

    • NAID

      130005966807

    • ISSN
      0016-2590, 2185-4610
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protection from lethal herpes simplex virus type 1 infection by vaccination with a UL41-deficient recombinant strain2016

    • Author(s)
      Koshizuka T, Ishioka K, Kobayashi T, Ikuta K, Suzutani T.
    • Journal Title

      FUKUSHIMA JOURNAL OF MEDICAL SCIENCE

      Volume: 62 Issue: 1 Pages: 36-42

    • DOI

      10.5387/fms.2015-24

    • NAID

      130005156335

    • ISSN
      0016-2590, 2185-4610
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 日本人由来「無症候感染EBウイルス株」解析の試み2018

    • Author(s)
      矢島美彩子、生田和史、神田 輝
    • Organizer
      第32回ヘルペスウイルス研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 先天性サイトメガロウイルス感染における胎盤栄養膜由来miRNA群の役割2018

    • Author(s)
      生田和史, 矢島美彩子, 神田 輝
    • Organizer
      第72回日本細菌学会東北支部総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 日本人由来EBウイルスゲノム塩基配列の解析2018

    • Author(s)
      矢島美彩子, 生田和史, 神田 輝
    • Organizer
      第72回日本細菌学会東北支部総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Placental microRNAs as a possible trigger of congenital Cytomegalovirus infection2018

    • Author(s)
      Ikuta K, Yajima M, Kanda T
    • Organizer
      第65回日本ウイルス学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 日本人由来「無症候感染EBウイルス株」解析の試み2018

    • Author(s)
      矢島美彩子, 生田和史, 神田 輝
    • Organizer
      第65回日本ウイルス学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Cytomegalovirus (CMV) IgG avidity test as a reliable index of CMV primary infection2017

    • Author(s)
      Ikuta K, Koshizuka T, Kanno R, Inoue N, Kubo T, Koyano S, Suzutani T.
    • Organizer
      42nd Annual International Herpesvirus Workshop
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] ブルーベリーのインフルエンザウイルス増殖抑制効果(品種比較)2017

    • Author(s)
      関澤春仁、生田和史、錫谷達夫
    • Organizer
      第64回日本食品科学工学会
    • Related Report
      2017 Research-status Report
  • [Presentation] An experimental strategy to analyze EBV strain variation of Japanese individuals2017

    • Author(s)
      Kanda T, Ikuta K, Yajima M.
    • Organizer
      第31回ヘルペスウイルス研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] サイトメガロウイルス感染による感音性難聴のウイルス学的検討2017

    • Author(s)
      生田和史
    • Organizer
      第62回日本聴覚医学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Experimental strategy to analyze EBV genome variation of Japanese2017

    • Author(s)
      Kanda T, Ikuta K, Yajima M.
    • Organizer
      第65回日本ウイルス学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] The investigation of time-dependent change to latent-infection marker UL138 and reactivation of a human cytomegalovirus2016

    • Author(s)
      Takahiro Kobayashi, Tetsuo Koshizuka, Kazufumi Ikuta, Ken Ishioka, Tatsuo Suzutani
    • Organizer
      第64回日本ウイルス学会
    • Place of Presentation
      札幌コンベンションセンター(北海道・札幌市)
    • Year and Date
      2016-10-23
    • Related Report
      2016 Research-status Report
  • [Presentation] Cytomegalovirus (CMV) reinfection in neonates with congenital CMV infection and their mothers.2016

    • Author(s)
      Kazufumi Ikuta, Toshio Minematsu, Naoki Inoue, Takahiko Kubo, Kimisato Asano, Kei Ishibashi, Takashi Imamura, Hidetaka Nakai, Tetsushi Yoshikawa, Hiroyuki Moriuchi, Shigeyoshi Fujiwara, Shin Koyano, and Tatsuo Suzutani
    • Organizer
      CMV Public Health & Policy Conference
    • Place of Presentation
      オースチン(アメリカ)
    • Year and Date
      2016-09-26
    • Related Report
      2016 Research-status Report
  • [Presentation] HCMV の潜伏感染マーカーUL138 の発現と再活性化における経時的検討2016

    • Author(s)
      小林敬広、野本芽衣、松岡 亮、腰塚哲朗、生田和史、石岡 賢、錫谷達夫
    • Organizer
      第70回日本細菌学会東北支部総会
    • Place of Presentation
      北里大学獣医学部十和田キャンパス(青森県・十和田市)
    • Year and Date
      2016-08-18
    • Related Report
      2016 Research-status Report
  • [Presentation] Suzutani T.:Murine model of cytomegalovirus-induced sensorineural hearing loss.2016

    • Author(s)
      Ikuta K., Ogawa H., Hashimoto H., Okano W., Tani A., Sato E., Kosugi I., Kobayashi T., Omori K., Suzutani T.
    • Organizer
      The 11th China-Japan International Conference of Virology.
    • Place of Presentation
      琴弾荘(香川県・観音寺市)
    • Year and Date
      2016-07-01
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] HCMV の潜伏感染マーカーUL138 の発現と再活性化における経時的検討2016

    • Author(s)
      小林敬広、野本芽衣、松岡 亮、腰塚哲朗、生田和史、石岡 賢、錫谷達夫
    • Organizer
      第30回ヘルペスウイルス研究会
    • Place of Presentation
      セミナーハウス クロスウェーブ・府中(東京都・府中市)
    • Year and Date
      2016-06-16
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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