Elucidation of pathophysiology of intraventricular hemorrhage in extremely low birth weight infants by VWF/ADAMTS-13/FVIII axis
| Project/Area Number |
16K10103
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
西本 瑛里 (濱中 瑛里) 奈良県立医科大学, 医学部, 助教 (00645591)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 極低出生体重児 / 脳室内出血 / 臍帯静脈血管内皮細胞 / 組織因子 / PAI-1 / VWF / 慢性肺疾患 / 極低出生体重 / von Willebrand因子 / 血液凝固第Ⅷ因子 / ADAMTS-13 / 臍帯 / 蛋白質 |
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| Outline of Final Research Achievements |
Intracerebroventricular hemorrhage (IVH) in very low birth weight (VLBW) infants is more likely to occur in VLBW infants with oxygen-induced respiratory distress due to hemorrhage in the subependymal layer.
Since umbilical veins are considered to be similar to blood vessels in the brain, umbilical vein endothelial cells of mature and VLBW infants were detached and cultured, and the effect of hydrogen peroxide solution on the expression of mRNA of coagulation-related factors was examined.
As a result, the expression levels of tissue factor and plasminogen activation inhibitor-1 mRNA were significantly increased in both mature and VLBW infants. That is, activation of the coagulation system and suppression of the fibrinolysis system were suggested. As a result, it was suggested that the production of fibrin clot was promoted and the degradation was suppressed, and that it might be involved in hemorrhage of venous venules in the subependymal layer.
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| Academic Significance and Societal Importance of the Research Achievements |
これまで、極低出生体重児における酸素毒性は、主として未熟児網膜症や慢性肺疾患の重症化に関係しているとされてきた。今回の研究結果は、呼吸障害を有する極低出生体重児における脳室内出血の発生機序として、酸素由来のスーパーオキシドやヒドロキシラジカルなどのフリーラジカルが血管内皮細胞に作用して、凝固亢進と線溶抑制を惹起することによる、IVH発症機序の可能性が示唆された。児への過剰酸素投与を予防することはIVH発症予防にも寄与する可能性がある、
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Report
(5 results)
Research Products
(38 results)
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[Journal Article] 手術介入なしで在宅医療に移行した18トリソミーの1例2019
Author(s)
佐伯しのぶ, 柳野 智, 渡壁麻依, 谷 有貴, 西本瑛里, 利根川 仁, 中川隆志, 釜本智之, 林 環, 内田優美子, 西久保敏也
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Journal Title
小児科臨床
Volume: 72
Pages: 1557-1562
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Peer Reviewed
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[Presentation] Plasminogen activator inhibitor-1 deficiency prevents the neonatal chronic lung disease in mice2019
Author(s)
Tatsumi K, Nishikubo T, Okada K, Mizuguchi N, Okumoto K, Fujito H, Takafuji Y, Ishida M, Kawao N, Matsuo O, Kaji H
Organizer
国際血栓止血学会2019 (ISTH)
Related Report
Int'l Joint Research
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[Presentation] The involvement of fibrinolytic system in the development of neonatal chronic lung disease in mice2019
Author(s)
Tatsumi K, Nishikubo T, Okada K, Mizuguchi N, Okumoto K, Takafuji Y, Ishida M, Kawao N, Shima M, Matsuo O, Kaji H
Organizer
第81回 日本血液学会
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