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Influence of ART on neonatal complications - genetic disorders, hospitalization in NICU

Research Project

Project/Area Number 16K10104
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Embryonic/Neonatal medicine
Research InstitutionJichi Medical University

Principal Investigator

Yada Yukari  自治医科大学, 医学部, 准教授 (00296089)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords生殖補助医療 / 新生児医療 / 先天異常 / 新生児
Outline of Final Research Achievements

ART have been employed for couples having difficulty conceiving. Previous studies indicated that ART result in the increased rates of the following conditions: multiple pregnancy, preterm delivery, and congenital anomalies. We attempt to determine the impact of ART on NICU practice. We retrieved all data of infants admitted to JMU Hospital NICU for 3 years,then assessed the clinical features and various morbidities of infants. Infants from ART were approximately 20% of all admissions. Although ART-related multiple births were reduced, 40% of all infants from ART were twins/triplets. And many of the ART-infants needed mechanical ventilation, but there was no statistically significant difference. It has been pointed out that one of the causes of anomalies in ART-infants is that micro changes such as deletion and duplication of chromosomes. We performed genetic searches on the infants with birth defects, but there was no specific accumulation.

Academic Significance and Societal Importance of the Research Achievements

ARTは日常的な治療となっており、新生児医療の対象となるARTからの出生児も増加している。本研究の成果は今後の新生児医療の体制を考えるうえでの参考資料になる。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (2 results)

All 2020 2018

All Journal Article (2 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results)

  • [Journal Article] Synergic interaction between ritodrine and magnesium sulfate on the occurrence of critical neonatal hyperkalemia: A Japanese nationwide retrospective cohort study2020

    • Author(s)
      Yukari Yada, Akihide Ohkuchi, Katsufumi Otsuki, Keiji Goishi, Mari Takahashi, Naohiro Yonemoto, Shigeru Saito, Satoshi Kusuda & The Survey Group Studying the Effects of Tocolytic Agents on Neonatal Adverse Events in Japan Society of Perinatal and Neonatal Medicine
    • Journal Title

      Scientific Reports

      Volume: 10 Pages: 7804-7804

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ARTと児の合併症2018

    • Author(s)
      矢田ゆかり
    • Journal Title

      周産期医学

      Volume: 48 Pages: 11211123-11211123

    • Related Report
      2018 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2021-02-19  

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