Identification and functional analyzes of chemical-induced vitiligo susceptibility genes.
| Project/Area Number |
16K10123
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Yamagata University |
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Principal Investigator |
Suzuki Tamio 山形大学, 医学部, 教授 (30206502)
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| Research Collaborator |
Hozumi Yutaka
Araki Yuta
Okamura Ken
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 尋常性白斑 / 化学物質誘発性白斑 / 感受性遺伝子 / ロドデノール / 機能解析 / 遺伝学 / 化学物質 |
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| Outline of Final Research Achievements |
In order to identify susceptibility genes for chemical-induced vitiligo, we identified at least one gene in genome-wideassociation study in 147 patients with Rhododenol-induced leukoderma (RD) and 112 controls. No loci did not achieve genome-wide significance (P<5x10-8), however, 3 loci achieved suggestive level (P<10-6). Functional investigation revealed that one of the 3 loci, gene A, would be a susceptibility gene for RD with siRNA and expression experiments. Furthermore, the gene A was turned out to not contribute susceptibility to another chemicals.
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| Academic Significance and Societal Importance of the Research Achievements |
2013年7月に社会問題となったRD白斑は、当該化粧品を使用したすべての人に発症しているわけではなく、発症率は使用者の約2％強であった。この発症率はこれまでに報告されてきた他の化学物質誘発性尋常性白斑の発症率とほぼ同様であったことから、化学白斑発症には共通する感受性遺伝子の存在が予想されていたが、本研究により、そのうちの1つを明らかにすることができた。この遺伝子多型を持つ人は、化学物質誘発性尋常性白斑の発症の危険性が高いことを化粧品等を使用前に予想することが可能となった。
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Spectrophotometer is useful for assessing vitiligo and chemical leukoderma severity by quantifying color difference with surrounding normally pigmented skin.2018
Author(s)
Hayashi M, Okamura K, Araki Y, Suzuki M, Tanaka T, Abe Y, Nakano S, Yoshizawa J, Hozumi Y, Inoie M, Suzuki T
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Journal Title
Skin Res Technol.
Volume: 24
Issue: 2
Pages: 175-179
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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