| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Outline of Final Research Achievements |
We have already reported that ultraviolet-(UV) induced inflammation might involve the mechanism of UV-induced skin carcinogenesis. We this time utilised Xpa knockout mice, the model of Xeroderma pigmentosum type A that reveal marked increased skin cancer and abnormal inflammatory skin reaction by UV for detecting some important molecules related to this extreme phenotype. We have performed microarray to obtain up-regulated genes in Xpa knockout mice compared to wild-type mice and found CXCL1, that is neutrophils-attractant chemokine was significantly up-regulated in both mRNA and protein level. Furthermore, when we administered the CXCXL1 neutralising antibody with chronic UVB exposure for Xpa knockout mice, the tumor production has been significantly decreased and the induction of skin tumor development also showed delayed compared to the control group. These results suggests that CXCL1 is critical molecule related to UV-induced inflammation as well as skin tumor development.
|
