| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
IL-33 is expressed in nucleus of epithelial and endothelial cells, and knockdown of IL-33 increased binucleated cells and decreased cell proliferation in normal human epidermal keratinocytes (NHEKs). This cause was to attenuate function of contractile ring for cytokinesis. Time laps observation revealed that cell division failed to cytokinesis. In the other hand, IL-33 expression plasmids which expressed various length of IL-33 were transfected to NHEKs, and it was irradiated UVB. IL-33 transfected NHEKs did not gain the tolerance for UVB. And addition, IL-33 transfected cells did not obtain cell proliferation. In order to examine the function of IL-33 against to psoriasis, it was investigated imiquimod induced mouse model. Imiquimod induced inflammation was significantly reduced in IL-33KO mice.
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