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Risk assesment of chemical leukoderma

Research Project

Project/Area Number 16K10152
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dermatology
Research InstitutionInstitute for Developmental Research Aichi Developmental Disability Center (2017-2019)
Nagoya University (2016)

Principal Investigator

Iida Machiko  愛知県医療療育総合センター発達障害研究所, 障害モデル研究部, 研究員 (60465515)

Co-Investigator(Kenkyū-buntansha) 加藤 昌志  名古屋大学, 医学系研究科, 教授 (10281073)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords白斑 / 毒性評価 / 皮膚疾患 / モデルマウス / 皮膚 / 毒性 / 色素細胞学
Outline of Final Research Achievements

Leukoderma is a skin disorder in which patchy hypopigmentation develops. Recently, more than 16,000 people in Asian countries developed chemical leukoderma due to the use of whitening agents containing 2% (w/w) rhododenol. Previous studies showed that 30% rhododenol caused leukoderma in animal experiments. However, the development of leukoderma caused by lower concentrations of chemicals such as 2% rhododenol, has not been reported. We demonstrated that external treatment with 2% rhododenol and 2% raspberry ketone caused the development of leukoderma in the tail skin of hairless mice with loss of epidermal melanocytes and melanin in the lesions. Thus, we developed a novel evaluation system that enables sensitive assessment of the risks of chemical leukoderma.

Academic Significance and Societal Importance of the Research Achievements

化学物質による白斑被害を未然に防ぐには、白斑毒性を高感度に検知できるシステムが求められる。本研究ではヒト類似皮膚をもつモデルマウスにこれまでの報告にはない低濃度(2%ロドデノール, 2%ラズベリーケトン)の化学物質を外用し白斑毒性が再現されるかを検討した。その結果、過去の皮膚毒性試験ではほとんど着目されることのなかった尾部皮膚において例外なく白斑を誘発することに成功した。モデルマウスの尾の皮膚を用いた本試験法は、化学物質による白斑毒性を高感度に検知できる新たな毒性評価法として有用である可能性がある。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (21 results)

All 2020 2019 2018 2017 2016 Other

All Journal Article (14 results) (of which Int'l Joint Research: 10 results,  Peer Reviewed: 14 results,  Open Access: 9 results) Presentation (3 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Remarks (3 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Peptides containing the MXXCW motif inhibit oncogenic RET kinase activity with a novel mechanism of action.2020

    • Author(s)
      Takeda K, Kawamoto Y, Nagasaki Y, Okuno Y, Goto Y, Iida M1, Yajima I, Ohgami N, Kato M.
    • Journal Title

      Peptides containing the MXXCW motif inhibit oncogenic RET kinase activity with a novel mechanism of action.

      Volume: 10 Pages: 336-349

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A unique system that can sensitively assess the risk of chemical leukoderma by using murine tail skin2019

    • Author(s)
      Iida Machiko、Tazaki Akira、Deng Yuqi、Chen Wei、Yajima Ichiro、Kondo-Ida Lisa、Hashimoto Kazunori、Ohgami Nobutaka、Kato Masashi
    • Journal Title

      Chemosphere

      Volume: 235 Pages: 713-718

    • DOI

      10.1016/j.chemosphere.2019.06.185

    • NAID

      120006777551

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Inhibition of mast cell degranulation by melanin.2019

    • Author(s)
      Kawamoto Y, Kondo H, Hasegawa M, Kurimoto C, Ishii Y, Kato C, Botei T, Shinya M, Murate T, Ueno Y, Kawabe M, Goto Y, Yamamoto R, Iida M, Yajima I, Ohgami N, Kato M, Takeda K.
    • Journal Title

      Biochem Pharmacol.

      Volume: 163 Pages: 178-193

    • DOI

      10.1016/j.bcp.2019.02.015

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histological analysis of the skin of Abca1-deleted mice: A potential model for dry skin2019

    • Author(s)
      Deng Yuqi、Ohgami Nobutaka、Iida Machiko、Tazaki Akira、Intoh Atsushi、Kondo-Ida Lisa、Lu Rui、Tsuzuki Toyonori、Yokoyama Shinji、Kato Masashi
    • Journal Title

      Eur J Dermatol

      Volume: 29 Issue: 5 Pages: 549-551

    • DOI

      10.1684/ejd.2019.3621

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Arsenic level in toenails is associated with hearing loss in humans.2018

    • Author(s)
      Li X, Ohgami N, Yajima I, Xu H, Iiida M, Ohino R, Ninomiya H, Shen D, Ahsan N, Akhand AA, Kato M
    • Journal Title

      PLoS ONE

      Volume: 13 Issue: 7 Pages: e0198743-e0198743

    • DOI

      10.1371/journal.pone.0198743

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A comprehensive study including monitoring, assessment of health effects and development of a remediation method for chromium pollution2018

    • Author(s)
      Yoshinaga M, Ninomiya H, Al Hossain MMA, Sudo M, Akhand AA, Ahsan N, Alim MA, Khalequzzaman M, Iida M, Yajima I, Ohgami N, Kato M.
    • Journal Title

      Chemosphere

      Volume: 201 Pages: 667-75

    • DOI

      10.1016/j.chemosphere.2018.03.026

    • NAID

      120006496424

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Increased expression level of Hsp70 in the inner ears of mice by exposure to low frequency noise.2018

    • Author(s)
      Ninomiya H, Ohgami N, Oshino R, Kato M, Ohgami K, Li X, Shen D, Iida M, Yajima I, Angelidis CE, Adachi H, Katsuno M, Sobue G, Kato M.
    • Journal Title

      Hear Res

      Volume: - Pages: 49-54

    • DOI

      10.1016/j.heares.2018.02.006

    • NAID

      120006517664

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Loss of Stemness, EMT, and Supernumerary Tooth Formation in Cebpb-/-Runx2+/- Murine Incisors.2018

    • Author(s)
      Saito K, Takahashi K, Huang B, Asahara M, Kiso H, Togo Y, Tsukamoto H, Mishima S, Nagata M, Iida M, Tokita Y, Asai M, Shimizu A, Komori T, Harada H, MacDougall M, Sugai M, Bessho K.
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 5169-5169

    • DOI

      10.1038/s41598-018-23515-y

    • NAID

      120006545187

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Use of Anti-phospho-girdin Antibodies to Visualize Intestinal Tuft Cells in Free-Floating Mouse Jejunum Cryosections.2018

    • Author(s)
      Mizutani Y, Kuga D, Iida M, Ushida K, Takagi T, Tokita Y, Takahashi M, Asai M.
    • Journal Title

      Journal of visualized experiments: JoVE

      Volume: 21 Issue: 133 Pages: 133-133

    • DOI

      10.3791/57475

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oral exposure to arsenic causes hearing loss in young people aged 12-29 years and in young mice.2017

    • Author(s)
      Li X, Ohgami N, Omata Y, Yajima I, Iida M, Oshino R, Ohnuma S, Ahsan N, Akhand AA, Kato M.
    • Journal Title

      Sci Rep

      Volume: 7 Issue: 1 Pages: 6844-6844

    • DOI

      10.1038/s41598-017-06096-0

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Manganese-mediated decrease in levels of c-RET and tyrosine hydroxylase expression in vitro.2017

    • Author(s)
      Kumasaka MY, Yajima I, Ohgami N, Ninomiya H, Iida M, Li X, Oshino R, Tanihata H, Yoshinaga M, Kato M.
    • Journal Title

      Neurotox Res

      Volume: 32 Issue: 4 Pages: 661-70

    • DOI

      10.1007/s12640-017-9783-0

    • NAID

      120006367974

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Arsenic-mediated hyperpigmented skin via NF-kappa B/Endothelin1 signaling in an originally developed hairless mouse model.2017

    • Author(s)
      Yajima I, Kumasaka MY, Iida M, Osino R, Tanihata H, Al Hossain A MM, Ohgami N, Kato M.
    • Journal Title

      Arch Toxicol

      Volume: 91 Issue: 11 Pages: 3507-16

    • DOI

      10.1007/s00204-017-1975-0

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Arsenic levels in cutaneous appendicular organs are correlated with digitally evaluated hyperpigmented skin of the forehead but not the sole in Bangladesh residents.2017

    • Author(s)
      Yajima I, Ahsan N, Akhand AA, Al Hossain MA, Yoshinaga M, Ohgami N, Iida M, Oshino R, Naito M, Wakai K, Kato M.
    • Journal Title

      Journal of Exposure Science & Environmental Epidemiology

      Volume: 28 Issue: 1 Pages: 64-68

    • DOI

      10.1038/jes.2016.70

    • NAID

      120006473550

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Noninvasive, label-free, three-dimensional imaging of melanoma with confocal photothermal microscopy: Differentiate malignant melanoma from benign tumor tissue.2016

    • Author(s)
      He J, Wang N, Tsurui H, Kato M, Iida M, Kobayashi T
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 30209-30209

    • DOI

      10.1038/srep30209

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] APPLICATION OF NON-THERMAL ATMOSPHERIC PRESSURE PLASMA IRRADIATION TO SPONTANEOUSLY DEVELOPED MELANOMA IN MICE2017

    • Author(s)
      Machiko Iida, Yasuhiro Omata, Takehito Kajiwara, Ichiro Yajima, Masaru Hori, Masashi Kato
    • Organizer
      International Conference on Plasma Medical Science Innovation (ICPMSI) 2017
    • Place of Presentation
      Nagoya University(愛知県名古屋市)
    • Year and Date
      2017-02-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] メラノーマ自然発症モデルマウスにおける非熱プラズマの発癌予防効果2016

    • Author(s)
      飯田真智子、小又尉広、矢嶋伊知朗、加藤祐貴、長谷川まり、中野千尋、鄒存超、李香、大神信孝、加藤昌志
    • Organizer
      第86回日本衛生学会学術総会
    • Place of Presentation
      旭川市民文化会館(北海道旭川市)
    • Year and Date
      2016-05-11
    • Related Report
      2016 Research-status Report
  • [Presentation] 動物モデルを用いた紫外線による健康リスクの多角的評価2016

    • Author(s)
      李香、鄒存超、矢嶋伊知朗、大神信孝、加藤昌志
    • Organizer
      第86回日本衛生学会学術総会
    • Place of Presentation
      旭川市民文化会館(北海道旭川市)
    • Year and Date
      2016-05-11
    • Related Report
      2016 Research-status Report
  • [Remarks] 愛知県医療療育総合センター 発達障害研究所

    • URL

      https://www.pref.aichi.jp/addc/eachfacility/hattatsu/department/index5.html

    • Related Report
      2018 Research-status Report
  • [Remarks] 名古屋大学大学院医学系研究科 環境労働衛生学ホームページ

    • URL

      https://www.med.nagoya-u.ac.jp/hygiene/

    • Related Report
      2017 Research-status Report
  • [Remarks] 名古屋大学大学院医学系研究科環境労働衛生学 ホームページ

    • URL

      https://www.med.nagoya-u.ac.jp/hygiene/

    • Related Report
      2016 Research-status Report
  • [Patent(Industrial Property Rights)] 白斑毒性及び黒皮症毒性の試験方法2016

    • Inventor(s)
      加藤昌志、飯田真智子
    • Industrial Property Rights Holder
      国立大学法人名古屋大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-104698
    • Filing Date
      2016-05-25
    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2021-02-19  

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