Elucidation of pathogenesis of IgE-dependent type I allergy which crosses species and involvement of CCD
| Project/Area Number |
16K10157
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Shimane University |
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Principal Investigator |
Chinuki Yuko 島根大学, 学術研究院医学・看護学系, 講師 (00294380)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 糖鎖 / 獣肉アレルギー / カレイ魚卵アレルギー / セツキシマブ / 交差反応 / α-Gal / マダニ / 獣肉 / アナフィラキシーショック / アニサキス / ハチ / ハチアレルギー / アニサキスアレルギー / アレルギー |
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| Outline of Final Research Achievements |
We have previously reported that patients with red meat allergy in Japan show allergic symptoms to the antibody biologic cetuximab, flounder roe, due to cross-reactivity. The causative allergen of red meat and cetuximab is sugar chain galactose-α-1,3-galactose (α-Gal). According to our clinical analysis, many of the patients with red meat allergy developed anisakis allergy and bee venom allergy. Therefore, we examined cross-reaction, but could not prove.
However, in this study, we identified the causative allergen of flounder roe allergy that cross-reacts with red meat allergy. Although it was not α-Gal itself, the involvement of intersecting sugar chains became clear.
This is considered to be a cross allergic reaction across species.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究においてカレイ魚卵アレルギーの原因となるアレルゲンの主な構造がタンパク質に結合する糖鎖であることを証明し、哺乳類肉の原因アレルゲンの糖鎖と交差反応することが判明した。つまり、類似した構造のアレルゲンが生物種を超えて存在することがわかった。これまで、食物アレルギーの原因の主なものはタンパク質であると考えられてきたが、本研究によって、食物アレルギー発症における糖鎖の関与の重要性が判明し、今後の食物アレルギーの発症機序の解明に新たな知見を与えるものと期待される。
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Report
(4 results)
Research Products
(40 results)
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[Journal Article] Efficacy and safety of omalizumab for the treatment of refractory chronic spontaneous urticaria in Japanese patients: Subgroup analysis of the phase 3 POLARIS study2018
Author(s)
Hide M, Igarashi A, Yagami A, Chinuki Y, Inomata N, Fukunaga A, Kaiser G, Wang J, Matsushima S, Greenberg S, Khalil S.
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Journal Title
Allergology International
Volume: 67
Issue: 2
Pages: 243-252
DOI
NAID
ISSN
1323-8930, 1440-1592
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Outbreak of immediate-type hydrolyzed wheat protein allergy due to a facial soap in Japan.2017
Author(s)
Yagami A, Aihara M, Ikezawa Z, Hide M, Kishikawa R, Morita E, Chinuki Y, Fukutomi Y, Urisu A, Fukushima A, Itagaki Y, Sugiura SI, Tanaka H, Teshima R, Kato Z, Noguchi E, Nakamura M, Saito H, Matsunaga K.
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Journal Title
J Allergy Clin Immunol.
Volume: 140
Issue: 3
Pages: 879-881
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Efficacy and safety of omalizumab in Japanese and Korean patients with refractory chronic spontaneous urticaria2017
Author(s)
Hide M, Park HS, Igarashi A, Ye YM, Kim TB, Yagami A, Roh J, Lee JH, Chinuki Y, Youn SW, Lee SK, Inomata N, Choi JH, Fukunaga A, Wang J, Matsushima S, Greenberg S, Khalil S.
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Journal Title
Journal of Dermatological Science
Volume: 87
Issue: 1
Pages: 70-78
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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