IL-17-induced gene expression in human epidermal keratinocytes

Research Project

Project/Area Number	16K10160
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Dermatology
Research Institution	Ehime University
Principal Investigator	Tohyama Mikiko 愛媛大学, 医学系研究科, 准教授 (60263935)
Project Period (FY)	2016-04-01 – 2019-03-31
Project Status	Completed (Fiscal Year 2018)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	乾癬 / アトピー性皮膚炎 / IL-17 / Bcl-3 / IκBζ / 尋常性乾癬 / IΚBζ / keratinocyte / CYLD / IkappaB zeta / 免疫学 / 表皮角化細胞
Outline of Final Research Achievements	In chronic inflammatory skin diseases such as atopic dermatitis and psoriasis, epidermal keratinocytes show different responses against cytokines released by infiltrated lymphocytes, resulting in different pathological conditions. We analyzed roles of IκBζ in IL-17-induced gene expression in epidermal keratinocytes. We elucidated that IκBζ significantly contributes to gene expressions observed in psoriasis lesion skin.
Academic Significance and Societal Importance of the Research Achievements	IκB family の１つである核内蛋白のIκBζが、ヒト表皮角化細胞におけるIL-17による遺伝子発現の制御において必須の因子であり、乾癬の病態において本質的な役割を果たしている可能性を明らかにした。病態形成に必要な分子を明らかにすることは、疾患の病態の理解を深め、新規治療の開発においても有意義である。