Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Outline of Final Research Achievements |
In chronic inflammatory skin diseases such as atopic dermatitis and psoriasis, epidermal keratinocytes show different responses against cytokines released by infiltrated lymphocytes, resulting in different pathological conditions. We analyzed roles of IκBζ in IL-17-induced gene expression in epidermal keratinocytes. We elucidated that IκBζ significantly contributes to gene expressions observed in psoriasis lesion skin.
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