IL-17-induced gene expression in human epidermal keratinocytes
Project/Area Number |
16K10160
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Dermatology
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Research Institution | Ehime University |
Principal Investigator |
Tohyama Mikiko 愛媛大学, 医学系研究科, 准教授 (60263935)
|
Project Period (FY) |
2016-04-01 – 2019-03-31
|
Project Status |
Completed (Fiscal Year 2018)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 乾癬 / アトピー性皮膚炎 / IL-17 / Bcl-3 / IκBζ / 尋常性乾癬 / IΚBζ / keratinocyte / CYLD / IkappaB zeta / 免疫学 / 表皮角化細胞 |
Outline of Final Research Achievements |
In chronic inflammatory skin diseases such as atopic dermatitis and psoriasis, epidermal keratinocytes show different responses against cytokines released by infiltrated lymphocytes, resulting in different pathological conditions. We analyzed roles of IκBζ in IL-17-induced gene expression in epidermal keratinocytes. We elucidated that IκBζ significantly contributes to gene expressions observed in psoriasis lesion skin.
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Academic Significance and Societal Importance of the Research Achievements |
IκB family の1つである核内蛋白のIκBζが、ヒト表皮角化細胞におけるIL-17による遺伝子発現の制御において必須の因子であり、乾癬の病態において本質的な役割を果たしている可能性を明らかにした。病態形成に必要な分子を明らかにすることは、疾患の病態の理解を深め、新規治療の開発においても有意義である。
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Report
(4 results)
Research Products
(2 results)
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[Journal Article] Bcl-3 induced by IL-22 via STAT3 activation acts as a potentiator of psoriasis-related gene expression in epidermal keratinocytes.2018
Author(s)
20.Tohyama M, Shirakata Y, Hanakawa Y, Dai X, Shiraishi K, Murakami M, Miyawaki S, Mori H, Utsunomiya R, Masuda K, Hashimoto K, Sayama K.
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Journal Title
Eur J Immunol
Volume: 48
Issue: 1
Pages: 168-179
DOI
Related Report
Peer Reviewed
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