Research Project
Grant-in-Aid for Scientific Research (C)
We identified the molecules up-regulated or down-regulated with cDNA microarray analyses using skin sections and cultured dermal fibroblasts from patients with systemic sclerosis (SSc). We also identified microRNAs up-regulated or down-regulated with microRNA array analyses in SSc. We identified the such molecules in integrinαVβ5 stable transfectants and TSP-1 stable transfectants. And we investigated the function of these microRNAs. We established TSP-1 transgenic mice using collagen promoter/ enhancer, and confirmed the extent of the over-expression of it in each organ. We investigated the skin, lung, and liver histologically, and inverstigated the expression of various molecules. And we investigated the existence of M2 macrophagesand the expression of B cell markers, Th2 cytokine, and interleukin-17
線維化の機序は未だ明らかでなく、線維化の治療も未だ確立せず、本邦においても、世界中でも多くの方が線維化を伴う疾患に罹患し、苦しみ、また結果として死を迎えている。線維化は、TGFβおよびTGFβ情報伝達の関与が考えられているが、その詳細は明らかではない。本研究により、線維化に対するTGFβ情報伝達の関与が詳細に明らかになれば、線維化治療のターゲット明らかになり、線維化治療法の開発が進み、学術的にも社会的にも大きなインパクトがある。
All 2019 2018 2017 2016
All Journal Article (76 results) (of which Int'l Joint Research: 9 results, Peer Reviewed: 76 results, Open Access: 12 results, Acknowledgement Compliant: 3 results) Presentation (112 results) (of which Int'l Joint Research: 5 results, Invited: 4 results) Book (7 results)
Intractable & Rare Diseases Research
Volume: 8 Issue: 1 Pages: 20-23
10.5582/irdr.2019.01010
130007612176
Modern Rheumatology
Volume: - Issue: 1 Pages: 1-23
10.1080/14397595.2019.1589739
The Journal of dermatology
Volume: 印刷中 Issue: 5 Pages: 444-448
10.1111/1346-8138.14858
Journal of Dermatological Science
Volume: 93 Issue: 2 Pages: 123-132
10.1016/j.jdermsci.2019.01.005
Dermatologic Therapy
Volume: - Issue: 3
10.1111/dth.12859
The Journal of Dermatology
Volume: 印刷中 Issue: 8
10.1111/1346-8138.14819
Journal of dermatological science
Volume: 93 Issue: 1 Pages: 33-10
10.1016/j.jdermsci.2018.10.001
Volume: 印刷中 Issue: 6
10.1111/1346-8138.14769
Volume: 印刷中 Issue: 7
10.1111/1346-8138.14788
Volume: 45 Issue: 11 Pages: 1362-1366
10.1111/1346-8138.14616
The Journal of investigative dermatology
Volume: 139 Issue: 4 Pages: 954-957
10.1016/j.jid.2018.09.030
Volume: 7 Issue: 4 Pages: 280-282
10.5582/irdr.2018.01110
130007533862
BioScience Trends
Volume: 12 Issue: 4 Pages: 438-441
10.5582/bst.2018.01118
130007484789
Volume: 7 Issue: 2 Pages: 138-140
10.5582/irdr.2018.01050
130007396053
Volume: 46 Issue: 1 Pages: 46-47
10.1111/1346-8138.14506
J. Invest. Dermatol.
Volume: 138 Issue: 12 Pages: 2550-2557
10.1016/j.jid.2018.05.015
Journal of lipid research
Volume: 59 Issue: 12 Pages: 2413-1420
10.1194/jlr.p087536
Antiviral Research
Volume: 149 Pages: 78-88
10.1016/j.antiviral.2017.09.003
Volume: 92 Issue: 3 Pages: 230-236
10.1016/j.jdermsci.2018.10.004
The Journal of Emergency Medicine
Volume: 54 Issue: 4 Pages: 514-515
10.1016/j.jemermed.2017.12.017
Volume: 45 Issue: 11
10.1111/1346-8138.14351
Volume: 0 Issue: 6 Pages: 0-0
10.1111/1346-8138.14206
Volume: 45 Issue: 4 Pages: 431-435
10.1111/1346-8138.14214
Ann Clin Transl Neurol.
Volume: 5 Issue: 11 Pages: 1421-1427
10.1002/acn3.654
Volume: 45 Issue: 10 Pages: 1225-1228
10.1111/1346-8138.14575
Cancer Research
Volume: 78 Issue: 17 Pages: 5011-5022
10.1158/0008-5472.can-18-0118
Volume: - Issue: 9 Pages: 929-978
10.1111/1346-8138.14587
Volume: 45 Issue: 7 Pages: 755-780
10.1111/1346-8138.14161
Volume: 45 Issue: 6 Pages: 633-691
10.1111/1346-8138.14162
J Dermatol.
Volume: 45 Issue: 4 Pages: 507-508
10.1111/1346-8138.14235
YAKUGAKU ZASSHI
Volume: 138 Issue: 4 Pages: 509-515
10.1248/yakushi.17-00201-4
130006601914
Arthritis Research & Therapy
Volume: 20 Issue: 1 Pages: 46-46
10.1186/s13075-018-1534-y
J Dermatol Sci.
Volume: 90 Issue: 1 Pages: 52-59
10.1016/j.jdermsci.2017.12.017
Volume: 印刷中 Issue: 8 Pages: 891-897
10.1111/1346-8138.14171
Volume: 印刷中 Issue: 8 Pages: 881-890
10.1111/1346-8138.14160
Volume: 印刷中 Issue: 5
10.1111/1346-8138.14147
Histochemistry and Cell Biology
Volume: 149 Issue: 2 Pages: 161-167
10.1007/s00418-017-1621-1
Volume: 印刷中 Issue: 4
10.1111/1346-8138.14109
Scientific Reports
Volume: 7 Issue: 1 Pages: 12654-12654
10.1038/s41598-017-12836-z
Volume: 45 Issue: 1 Pages: 67-71
10.1111/1346-8138.14010
Volume: 44 Issue: 12
10.1111/1346-8138.13986
Eur J Dermatol.
Volume: 27 Issue: 5 Pages: 464-471
10.1684/ejd.2017.3084
Volume: 44 Issue: 11 Pages: 1228-1237
10.1111/1346-8138.13956
Volume: 44 Issue: 7 Pages: 838-839
10.1111/1346-8138.13631
Drug Discoveries & Therapeutics
Volume: 11 Issue: 3 Pages: 152-155
10.5582/ddt.2017.01022
130005875038
Journal of Investigative Dermatology
Volume: 137 Issue: 9 Pages: 1878-1886
10.1016/j.jid.2017.04.028
Clin Exp Rheumatol.
Volume: 106 Pages: 208-210
Exp Dermatol
Volume: 印刷中 Issue: 11 Pages: 1139-1143
10.1111/exd.13366
Volume: 144 Pages: 83-92
10.1016/j.antiviral.2017.03.027
Volume: 印刷中 Issue: 8 Pages: 927-931
10.1111/1346-8138.13838
10.1111/1346-8138.13826
Cancer Sci
Volume: 108 Issue: 6 Pages: 1223-1230
10.1111/cas.13241
Ann Rheum Dis.
Volume: 印刷中 Issue: 6 Pages: 1150-1158
10.1136/annrheumdis-2016-210645
Volume: 44 Issue: 7
10.1111/1346-8138.13818
Acta Derm Venereol.
Volume: 97 Issue: 6 Pages: 765-766
10.2340/00015555-2647
Cancer Chemotherapy and Pharmacology
Volume: 79 Issue: 4 Pages: 651-660
10.1007/s00280-016-3237-x
Cancer Sci.
Volume: 108 Issue: 5 Pages: 1022-1031
10.1111/cas.13226
Volume: 44 Issue: 4
10.1111/1346-8138.13765
Volume: 44 Issue: 5
10.1111/1346-8138.13693
Volume: 44 Issue: 5 Pages: 95-96
10.1111/1346-8138.13683
Volume: 44 Issue: 4 Pages: 355-362
10.1111/1346-8138.13622
Volume: 44 Issue: 7 Pages: 848-850
10.1111/1346-8138.13543
Australas J Dermatol.
Volume: 印刷中 Issue: 3
10.1111/ajd.12510
Volume: 44 Issue: 1 Pages: 88-90
10.1111/1346-8138.13570
Volume: 1 Issue: 1 Pages: 112-114
10.2340/00015555-2449
Volume: 44 Issue: 1 Pages: 13-17
10.1111/1346-8138.13497
European Journal of Dermatology
Volume: 1 Issue: 1 Pages: 20-27
10.1684/ejd.2016.2906
Br J Dermatol.
Volume: 印刷中 Issue: 2 Pages: 456-469
10.1111/bjd.15303
New England Journal of Medicine
Volume: 377 Issue: 19 Pages: 1824-1835
10.1056/nejmoa1709030
Dermatologica Sinica,
Volume: 35 Issue: 4 Pages: 213-214
10.1016/j.dsi.2017.04.002
Volume: 11 Issue: 6 Pages: 346-348
10.5582/ddt.2017.01067
130006308074
Int Canc Conf J
Volume: 印刷中
J Dermatol,
J Dermatol Sci
Volume: 85(2) Issue: 2 Pages: 77-84
10.1016/j.jdermsci.2016.11.003
Rheumatology (Oxford)
Volume: 56 Issue: 1 Pages: 145-155
10.1093/rheumatology/kew336
Volume: 10 Issue: 6 Pages: 454-459
10.5582/bst.2016.01102
130005295759