The investigation on the involvement of TGF-beta signal transduction in fibrosis

• Project/Area Number: 16K10165
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Kumamoto University
• Principal Investigator: IHN HIRONOBU 熊本大学, 大学院生命科学研究部(医), 教授 (20282634)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 遺伝子 / 細胞・組織 / シグナル伝達 / 皮膚免疫・炎症学

Outline of Final Research Achievements

We identified the molecules up-regulated or down-regulated with cDNA microarray analyses using skin sections and cultured dermal fibroblasts from patients with systemic sclerosis (SSc). We also identified microRNAs up-regulated or down-regulated with microRNA array analyses in SSc. We identified the such molecules in integrinαVβ5 stable transfectants and TSP-1 stable transfectants. And we investigated the function of these microRNAs. We established TSP-1 transgenic mice using collagen promoter/ enhancer, and confirmed the extent of the over-expression of it in each organ. We investigated the skin, lung, and liver histologically, and inverstigated the expression of various molecules. And we investigated the existence of M2 macrophagesand the expression of B cell markers, Th2 cytokine, and interleukin-17

Academic Significance and Societal Importance of the Research Achievements

線維化の機序は未だ明らかでなく、線維化の治療も未だ確立せず、本邦においても、世界中でも多くの方が線維化を伴う疾患に罹患し、苦しみ、また結果として死を迎えている。線維化は、TGFβおよびTGFβ情報伝達の関与が考えられているが、その詳細は明らかではない。本研究により、線維化に対するTGFβ情報伝達の関与が詳細に明らかになれば、線維化治療のターゲット明らかになり、線維化治療法の開発が進み、学術的にも社会的にも大きなインパクトがある。

Research Products

• [Journal Article] The expression of EpCAM in extramammary Paget's disease (2019)
  • Author(s): Yamada-Kanazawa Saori、Tasaki Yukino、Kajihara Ikko、Sakamoto Ryoko、Maeda-Otsuka Saki、Ihn Hironobu
  • Journal Title: Intractable & Rare Diseases Research Volume: 8 Issue: 1 Pages: 20-23
  • DOI: 10.5582/irdr.2019.01010
  • NAID: 130007612176
  • ISSN: 2186-361X, 2186-3644
  • Year and Date: 2019-02-28
  • Peer Reviewed
• [Journal Article] Efficacy and safety of adalimumab in Japanese patients with psoriatic arthritis and inadequate response to non-steroidal anti-inflammatory drugs (NSAIDs): A prospective, observational study (2019)
  • Author(s): Morita Akimichi、Okuyama Ryuhei、Katoh Norito、Tateishi Chiharu、Masuda Koji、Komori Toshifumi、Ogawa Eisaku、Makino Takamitsu、Nishida Emi、Nishimoto Shohei、Muramoto Kenzo、Tsuruta Daisuke、Ihn Hironobu
  • Journal Title: Modern Rheumatology Volume: - Issue: 1 Pages: 1-23
  • DOI: 10.1080/14397595.2019.1589739
  • Peer Reviewed
• [Journal Article] Overexpression of cyclin-dependent kinase 4 protein in extramammary Paget's disease. (2019)
  • Author(s): Urata K, Kajihara I, Myangat TM, Tasaki Y, Otsuka-Maeda S, Sawamura S, Kanazawa-Yamada S, Sakamoto R, Makino K, Aoi J, Igata T, Makino T, Masuguchi S, Fukushima S, Jinnin M, Ihn H
  • Journal Title: The Journal of dermatology Volume: 印刷中 Issue: 5 Pages: 444-448
  • DOI: 10.1111/1346-8138.14858
  • Peer Reviewed
• [Journal Article] Hypoxia accelerates the progression of angiosarcoma through the regulation of angiosarcoma cells and tumor microenvironment (2019)
  • Author(s): Maeda-Otsuka Saki、Kajihara Ikko、Tasaki Yukino、Yamada-Kanazawa Saori、Sakamoto Ryoko、Sawamura Soichiro、Masuzawa Mamiko、Masuzawa Mikio、Amoh Yasuyuki、Hoshina Daichi、Abe Riichiro、Komohara Yoshihiro、Ihn Hironobu
  • Journal Title: Journal of Dermatological Science Volume: 93 Issue: 2 Pages: 123-132
  • DOI: 10.1016/j.jdermsci.2019.01.005
  • Peer Reviewed
• [Journal Article] Infliximab improved the refractory cutaneous involvement in a patient with dermatomyositis (2019)
  • Author(s): Yamada-Kanazawa Saori、Kajihara Ikko、Kobayashi Atsuko、Watanabe Chinatsu、Ihn Hironobu
  • Journal Title: Dermatologic Therapy Volume: - Issue: 3
  • DOI: 10.1111/dth.12859
  • Peer Reviewed
• [Journal Article] Papulonecrotic tuberculid after Bacillus Calmette-Gu?rin (BCG) vaccination with lung infiltration that mimics disseminated BCG infection (2019)
  • Author(s): Miyamura Tomohiro、Egashira Sho、Yoshino Yuichiro、Sawatari Madoka、Nishihara Takahiro、Ihn Hironobu
  • Journal Title: The Journal of Dermatology Volume: 印刷中 Issue: 8
  • DOI: 10.1111/1346-8138.14819
  • Peer Reviewed
• [Journal Article] Serum concentrations of HGF are correlated with response to anti-PD-1 antibody therapy in patients with metastatic melanoma. (2019)
  • Author(s): Kubo Y, Fukushima S, Inamori Y, Tsuruta M, Egashira S, Yamada-Kanazawa S, Nakahara S, Tokuzumi A, Miyashita A, Aoi J, Kajihara I, Tomita Y, Wakamatsu K, Jinnin M, Ihn H
  • Journal Title: Journal of dermatological science Volume: 93 Issue: 1 Pages: 33-10
  • DOI: 10.1016/j.jdermsci.2018.10.001
  • Peer Reviewed / Open Access
• [Journal Article] Case of cutaneous myoepithelioma managed with surgical resection without recurrence for 4?years. (2019)
  • Author(s): Kanemaru H, Honda N, Kubo Y, Nishihara H, Onuma T, Sakai K, Fukushima S, Inoue Y, Honda Y, Ihn H
  • Journal Title: The Journal of dermatology Volume: 印刷中 Issue: 6
  • DOI: 10.1111/1346-8138.14769
  • Peer Reviewed
• [Journal Article] Natural course of epidermolysis bullosa simplex with mottled pigmentation in a Japanese family with the p.P25L mutation in KRT5. (2019)
  • Author(s): Okamura K, Fukushima S, Yamashita J, Abe Y, Hayashi M, Hozumi Y, Ihn H, Suzuki T
  • Journal Title: The Journal of dermatology Volume: 印刷中 Issue: 7
  • DOI: 10.1111/1346-8138.14788
  • Peer Reviewed
• [Journal Article] Onychomycosis caused by Aspergillus subramanianii. (2019)
  • Author(s): Hirose M, Noguchi H, Yaguchi T, Matsumoto T, Hiruma M, Fukushima S, Ihn H
  • Journal Title: The Journal of dermatology Volume: 45 Issue: 11 Pages: 1362-1366
  • DOI: 10.1111/1346-8138.14616
  • Peer Reviewed
• [Journal Article] Recurrent Fusion Gene ADCK4-NUMBL in Cutaneous Squamous Cell Carcinoma Mediates?Cell?Proliferation. (2019)
  • Author(s): Egashira S, Jinnin M, Makino K, Ajino M, Shimozono N, Okamoto S, Tazaki Y, Hirano A, Ide M, Kajihara I, Aoi J, Harada M, Igata T, Masuguchi S, Fukushima S, Ihn H
  • Journal Title: The Journal of investigative dermatology Volume: 139 Issue: 4 Pages: 954-957
  • DOI: 10.1016/j.jid.2018.09.030
  • Peer Reviewed / Open Access
• [Journal Article] A case of leg cellulitis caused by multidrug-resistant <i>Streptococcus pseudoporcinus </i> (2018)
  • Author(s): Sawamura Soichiro、Niimori Daisuke、Ihn Hironobu
  • Journal Title: Intractable & Rare Diseases Research Volume: 7 Issue: 4 Pages: 280-282
  • DOI: 10.5582/irdr.2018.01110
  • NAID: 130007533862
  • ISSN: 2186-361X, 2186-3644
  • Year and Date: 2018-11-30
  • Peer Reviewed / Open Access
• [Journal Article] Serum cytokine profiles are altered in patients with progressive infantile hemangioma (2018)
  • Author(s): Yamashita T, Jinnin M, Makino K, Kajihara I, Aoi J, Masuguchi S, Fukushima S, Ihn H
  • Journal Title: BioScience Trends Volume: 12 Issue: 4 Pages: 438-441
  • DOI: 10.5582/bst.2018.01118
  • NAID: 130007484789
  • ISSN: 1881-7815, 1881-7823
  • Year and Date: 2018-08-31
  • Peer Reviewed
• [Journal Article] Severe bacterial sepsis results in delayed diagnosis of tuberculous lymphadenitis in a rheumatoid arthritis patient treated with adalimumab (2018)
  • Author(s): Sawamura S, Makino T, Johno T, Yamashita J, Niimori D, Fukushima S, Ihn H
  • Journal Title: Intractable & Rare Diseases Research Volume: 7 Issue: 2 Pages: 138-140
  • DOI: 10.5582/irdr.2018.01050
  • NAID: 130007396053
  • ISSN: 2186-361X, 2186-3644
  • Year and Date: 2018-05-31
  • Peer Reviewed / Open Access
• [Journal Article] Simple and effective modification of the axial frontonasal flap to prevent flap distortion. (2018)
  • Author(s): Aoi J, Kajihara I, Masuguchi S, Fukushima S, Ihn H
  • Journal Title: The Journal of dermatology Volume: 46 Issue: 1 Pages: 46-47
  • DOI: 10.1111/1346-8138.14506
  • Peer Reviewed
• [Journal Article] Differential roles of Rad18 and Chk2 in genome maintenance and skin carcinogenesis following UV exposure. (2018)
  • Author(s): Tanoue, Y., Toyoda, T., Sun, J, Mustofa, M.K., Tateishi, C., Endo, S., Motoyama, N., Araki, K., Wu, D., Okuno, Y., Tsukamoto, T., Takeya, M., Ihn, H., Vaziri, C., Tateishi, S.
  • Journal Title: J. Invest. Dermatol. Volume: 138 Issue: 12 Pages: 2550-2557
  • DOI: 10.1016/j.jid.2018.05.015
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Reduction of stratum corneum ceramides in Neu-Laxova syndrome caused by phosphoglycerate dehydrogenase deficiency. (2018)
  • Author(s): Reduction of stratum corneum ceramides in Neu-Laxova syndrome caused by phosphoglycerate dehydrogenase deficiency.
  • Journal Title: Journal of lipid research Volume: 59 Issue: 12 Pages: 2413-1420
  • DOI: 10.1194/jlr.p087536
  • Peer Reviewed
• [Journal Article] Raltegravir blocks the infectivity of red-fluorescent-protein (mCherry)-labeled HIV-1 JR-FL in the setting of post-exposure prophylaxis in NOD/SCID/Jak3 ?/? mice transplanted with human PBMCs (2018)
  • Author(s): Ogata-Aoki Hiromi、Higashi-Kuwata Nobuyo、Hattori Shin-ichiro、Hayashi Hironori、Danish Matthew、Aoki Manabu、Shiotsu Chiemi、Hashiguchi Yumi、Hamada Akinobu、Kobayashi Hisataka、Ihn Hironobu、Okada Seiji、Mitsuya Hiroaki
  • Journal Title: Antiviral Research Volume: 149 Pages: 78-88
  • DOI: 10.1016/j.antiviral.2017.09.003
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Nation-wide survey of advanced non-melanoma skin cancers treated at dermatology departments in Japan (2018)
  • Author(s): Fujisawa Yasuhiro、Funakoshi Takeru、Nakamura Yoshiyuki、Ishii Maki、Asai Jun、Shimauchi Takatoshi、Fujii Kazuyasu、Fujimoto Manabu、Katoh Norito、Ihn Hironobu
  • Journal Title: Journal of Dermatological Science Volume: 92 Issue: 3 Pages: 230-236
  • DOI: 10.1016/j.jdermsci.2018.10.004
  • Peer Reviewed
• [Journal Article] First Aid for Skin Tears by Mini Patch Grafting from the Flap Edge (2018)
  • Author(s): Ikeda Isamu、Igata Toshikatsu、Ihn Hironobu
  • Journal Title: The Journal of Emergency Medicine Volume: 54 Issue: 4 Pages: 514-515
  • DOI: 10.1016/j.jemermed.2017.12.017
  • Peer Reviewed
• [Journal Article] Sweet's syndrome with laryngoparalysis due to laryngitis (2018)
  • Author(s): Miyamura Tomohiro、Kajihara Ikko、Makino Katsunari、Ihn Hironobu
  • Journal Title: The Journal of Dermatology Volume: 45 Issue: 11
  • DOI: 10.1111/1346-8138.14351
  • Peer Reviewed
• [Journal Article] Dabrafenib and trametinib combination therapy safely performed in a patient with metastatic melanoma after severe liver toxicity due to vemurafenib. (2018)
  • Author(s): Shimada S, Fukushima S, Niimori D, Miyashita A, Setoyama H, Sasaki Y, Ihn H.
  • Journal Title: The Journal of Dermatology Volume: 0 Issue: 6 Pages: 0-0
  • DOI: 10.1111/1346-8138.14206
  • Peer Reviewed / Open Access
• [Journal Article] Impact of a new simplified disability scoring system for adult patients with localized scleroderma (2018)
  • Author(s): Okiyama Naoko、Asano Yoshihide、Hamaguchi Yasuhito、Jinnin Masatoshi、Motegi Sei-ichiro、Koizumi Haruka、Hasegawa Minoru、Ishikawa Osamu、Sato Shinichi、Takehara Kazuhiko、Yamamoto Toshiyuki、Fujimoto Manabu、Ihn Hironobu
  • Journal Title: The Journal of Dermatology Volume: 45 Issue: 4 Pages: 431-435
  • DOI: 10.1111/1346-8138.14214
  • Peer Reviewed
• [Journal Article] Immune checkpoint inhibitors in the onset of myasthenia gravis with hyperCKemia. (2018)
  • Author(s): Koutaro Takamatsu, Shunya Nakane, Shigeaki Suzuki, Takayuki Kosaka, Satoshi Fukushima, Toshihiro Kimura, Azusa Miyashita, Akihiro Mukaino, Shiori Yamakawa, Keisuke Watanabe, Masatoshi Jinnin, Yoshihiro Komohara, Hironobu Ihn, and Yukio Ando
  • Journal Title: Ann Clin Transl Neurol. Volume: 5 Issue: 11 Pages: 1421-1427
  • DOI: 10.1002/acn3.654
  • Peer Reviewed / Open Access
• [Journal Article] Topical efinaconazole: A promising therapeutic medication for tinea unguium. (2018)
  • Author(s): Noguchi H, Matsumoto T, Hiruma M, Asao K, Hirose M, Fukushima S, Ihn H
  • Journal Title: The Journal of dermatology Volume: 45 Issue: 10 Pages: 1225-1228
  • DOI: 10.1111/1346-8138.14575
  • Peer Reviewed
• [Journal Article] Combined Blockade of IL6 and PD-1/PD-L1 Signaling Abrogates Mutual Regulation of Their Immunosuppressive Effects in the Tumor Microenvironment (2018)
  • Author(s): Tsukamoto Hirotake、Fujieda Koji、Miyashita Azusa、Fukushima Satoshi、Ikeda Tokunori、Kubo Yosuke、Senju Satoru、Ihn Hironobu、Nishimura Yasuharu、Oshiumi Hiroyuki
  • Journal Title: Cancer Research Volume: 78 Issue: 17 Pages: 5011-5022
  • DOI: 10.1158/0008-5472.can-18-0118
  • Peer Reviewed / Open Access
• [Journal Article] Wound, pressure ulcer and burn guidelines - 2: Guidelines for the diagnosis and treatment of pressure ulcers, second edition (2018)
  • Author(s): Fujiwara Hiroshi、Isogai Zenzo、Irisawa Ryokichi、Otsuka Masak、Fujimoto Manabu、Yamasaki Osamu、Tachibana Takao、Ihn Hironobu
  • Journal Title: The Journal of Dermatology Volume: - Issue: 9 Pages: 929-978
  • DOI: 10.1111/1346-8138.14587
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Diagnostic criteria, severity classification and guidelines of localized scleroderma (2018)
  • Author(s): Asano Yoshihide、Fujimoto Manabu、Ishikawa Osamu、Sato Shinichi、Jinnin Masatoshi、Takehara Kazuhiko、Hasegawa Minoru、Yamamoto Toshiyuki、Ihn Hironobu
  • Journal Title: The Journal of Dermatology Volume: 45 Issue: 7 Pages: 755-780
  • DOI: 10.1111/1346-8138.14161
  • Peer Reviewed
• [Journal Article] Diagnostic criteria, severity classification and guidelines of systemic sclerosis (2018)
  • Author(s): Asano Yoshihide、Jinnin Masatoshi、Kawaguchi Yasushi、Kuwana Masataka、Goto Daisuke、Sato Shinichi、Takehara Kazuhiko、Hatano Masaru、Fujimoto Manabu、Mugii Naoki、Ihn Hironobu
  • Journal Title: The Journal of Dermatology Volume: 45 Issue: 6 Pages: 633-691
  • DOI: 10.1111/1346-8138.14162
  • Peer Reviewed
• [Journal Article] Expression of aurora kinase A expression in dermatofibrosarcoma protuberans (2018)
  • Author(s): Sanayo Kanamori Ikko Kajihara Saori Kanazawa‐Yamada Saki Otsuka‐Maeda Hironobu Ihn
  • Journal Title: J Dermatol. Volume: 45 Issue: 4 Pages: 507-508
  • DOI: 10.1111/1346-8138.14235
  • Peer Reviewed
• [Journal Article] Anti-inflammatory Effect of Sacran on Atopic Dermatitis (2018)
  • Author(s): Arima Hidetoshi、Motoyama Keiichi、Higashi Taishi、Fukushima Satoshi、Ihn Hironobu
  • Journal Title: YAKUGAKU ZASSHI Volume: 138 Issue: 4 Pages: 509-515
  • DOI: 10.1248/yakushi.17-00201-4
  • NAID: 130006601914
  • ISSN: 0031-6903, 1347-5231
  • Peer Reviewed
• [Journal Article] Blockade of TGF-β/Smad signaling by the small compound HPH-15 ameliorates experimental skin fibrosis (2018)
  • Author(s): Luong Vu Huy、Chino Takenao、Oyama Noritaka、Matsushita Takashi、Sasaki Yoko、Ogura Dai、Niwa Shin-ichiro、Biswas Tanima、Hamasaki Akiyuki、Fujita Mikako、Okamoto Yoshinari、Otsuka Masami、Ihn Hironobu、Hasegawa Minoru
  • Journal Title: Arthritis Research & Therapy Volume: 20 Issue: 1 Pages: 46-46
  • DOI: 10.1186/s13075-018-1534-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Regulatory mechanisms of collagen expression by interleukin-22 signaling in scleroderma fibroblasts (2018)
  • Author(s): Sawamura Soichiro、Jinnin Masatoshi、Inoue Kuniko、Yamane Keitaro、Honda Noritoshi、Kajihara Ikko、Makino Takamitsu、Masuguchi Shinichi、Fukushima Satoshi、Ihn Hironobu
  • Journal Title: J Dermatol Sci. Volume: 90 Issue: 1 Pages: 52-59
  • DOI: 10.1016/j.jdermsci.2017.12.017
  • Peer Reviewed
• [Journal Article] Diagnostic criteria, severity classification and guideline of lichen sclerosus et atrophicus (2017)
  • Author(s): Hasegawa Minoru、Ishikawa Osamu、Asano Yoshihide、Sato Shinichi、Jinnin Masatoshi、Takehara Kazuhiko、Fujimoto Manabu、Yamamoto Toshiyuki、Ihn Hironobu、for the Executive Committee of Guideline
  • Journal Title: The Journal of Dermatology Volume: 印刷中 Issue: 8 Pages: 891-897
  • DOI: 10.1111/1346-8138.14171
  • Peer Reviewed
• [Journal Article] Guideline for diagnostic criteria, severity classification and treatment of eosinophilic fasciitis (2017)
  • Author(s): Jinnin Masatoshi、Yamamoto Toshiyuki、Asano Yoshihide、Ishikawa Osamu、Sato Shinichi、Takehara Kazuhiko、Hasegawa Minoru、Fujimoto Manabu、Ihn Hironobu
  • Journal Title: The Journal of Dermatology Volume: 印刷中 Issue: 8 Pages: 881-890
  • DOI: 10.1111/1346-8138.14160
  • Peer Reviewed
• [Journal Article] Case of pigmented lipofibromatosis in a 27-year-old woman (2017)
  • Author(s): Sonoda-Shimada Kanako、Kajihara Ikko、Shimada Shuichi、Igata Toshikatsu、Jinnin Masatoshi、Honda Yumi、Ihn Hironobu
  • Journal Title: The Journal of Dermatology Volume: 印刷中 Issue: 5
  • DOI: 10.1111/1346-8138.14147
  • Peer Reviewed
• [Journal Article] Expression and distribution patterns of spermine, spermidine, and putrescine in rat hair follicle (2017)
  • Author(s): Yamamoto Yutaro、Makino Takamitsu、Kudo Hideo、Ihn Hironobu、Murakami Yasuko、Matsufuji Senya、Fujiwara Kunio、Shin Masashi
  • Journal Title: Histochemistry and Cell Biology Volume: 149 Issue: 2 Pages: 161-167
  • DOI: 10.1007/s00418-017-1621-1
  • Peer Reviewed
• [Journal Article] Dyskeratosis congenita associated with congenital hypothyroidism (2017)
  • Author(s): Noda-Yamashita Tomoka、Kajihara Ikko、Kidou Masato、Ihn Hironobu
  • Journal Title: The Journal of Dermatology Volume: 印刷中 Issue: 4
  • DOI: 10.1111/1346-8138.14109
  • Peer Reviewed
• [Journal Article] Chronic sun exposure-related fusion oncogenes EGFR-PPARGC1A in cutaneous squamous cell carcinoma (2017)
  • Author(s): Egashira Sho、Jinnin Masatoshi、Ajino Manami、Shimozono Naoki、Okamoto Sayo、Tasaki Yukino、Hirano Ayaka、Ide Maho、Kajihara Ikko、Aoi Jun、Harada Miho、Igata Toshikatsu、Masuguchi Shinichi、Fukushima Satoshi、Ihn Hironobu
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 12654-12654
  • DOI: 10.1038/s41598-017-12836-z
  • Peer Reviewed
• [Journal Article] Case report of cutaneous protothecosis caused by Prototheca wickerhamii designated as genotype 2 and current status of human protothecosis in Japan (2017)
  • Author(s): Inoue Maki、Miyashita Azusa、Noguchi Hiromitsu、Hirose Noriyuki、Nishimura Kazuko、Masuda Michiaki、Ihn Hironobu
  • Journal Title: The Journal of Dermatology Volume: 45 Issue: 1 Pages: 67-71
  • DOI: 10.1111/1346-8138.14010
  • Peer Reviewed
• [Journal Article] Secukinumab-induced interstitial pneumonia in a patient with psoriasis vulgaris (2017)
  • Author(s): Kajihara Ikko、Yamada-Kanazawa Saori、Maeda-Otsuka Saki、Jinnin Masatoshi、Akaike Kimitaka、Ihn Hironobu
  • Journal Title: The Journal of Dermatology Volume: 44 Issue: 12
  • DOI: 10.1111/1346-8138.13986
  • Peer Reviewed
• [Journal Article] The role of miR-210, E2F3 and ephrin A3 in angiosarcoma cell proliferation. (2017)
  • Author(s): Nakashima S, Jinnin M, Kanemaru H, Kajihara I, Igata T, Okamoto S, Tazaki Y, Harada M, Masuguchi S, Fukushima S, Masuzawa M, Amoh Y, Masuzawa M, Ihn H.
  • Journal Title: Eur J Dermatol. Volume: 27 Issue: 5 Pages: 464-471
  • DOI: 10.1684/ejd.2017.3084
  • Peer Reviewed
• [Journal Article] Tofacitinib for the treatment of moderate to severe chronic plaque psoriasis in Japanese patients: Subgroup analyses from a randomized, placebo-controlled phase 3 trial (2017)
  • Author(s): Abe Masatoshi、Nishigori Chikako、Torii Hideshi、Ihn Hironobu、Ito Kei、Nagaoka Makoto、Isogawa Naoki、Kawaguchi Isao、Tomochika Yukiko、Kobayashi Mihoko、Tallman Anna M.、Papp Kim A.
  • Journal Title: The Journal of Dermatology Volume: 44 Issue: 11 Pages: 1228-1237
  • DOI: 10.1111/1346-8138.13956
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] S100A7 expression levels in coordination with interleukin-8 indicate the clinical response to infliximab for psoriasis patients (2017)
  • Author(s): Sato Yasuhiko、Kajihara Ikko、Yamada-Kanazawa Saori、Jinnin Masatoshi、Ihn Hironobu
  • Journal Title: The Journal of Dermatology Volume: 44 Issue: 7 Pages: 838-839
  • DOI: 10.1111/1346-8138.13631
  • Peer Reviewed
• [Journal Article] Intratumor dihydropyrimidine dehydrogenase mRNA expression levels are decreased in extramammary Paget&apos;s disease (2017)
  • Author(s): Nakamura Yuki、Kajihara Ikko、Yamada-Kanazawa Saori、Maeda-Otsuka Saki、Johno Takamitsu、Aoi Jun、Igata Toshikatsu、Masuguchi Shinichi、Fukushima Satoshi、Jinnin Masatoshi、Ihn Hironobu
  • Journal Title: Drug Discoveries & Therapeutics Volume: 11 Issue: 3 Pages: 152-155
  • DOI: 10.5582/ddt.2017.01022
  • NAID: 130005875038
  • ISSN: 1881-7831, 1881-784X
  • Peer Reviewed
• [Journal Article] RXRB Is an MHC-Encoded Susceptibility Gene Associated with Anti-Topoisomerase I?Antibody-Positive Systemic Sclerosis (2017)
  • Author(s): Oka Akira、Asano Yoshihide、Hasegawa Minoru、Fujimoto Manabu、Kawaguchi Yasushi、Takahashi Hiroki、Goto Daisuke、Endo Hirahito、Jinnin Masatoshi、Mano Shuhei、Hosomichi Kazuyoshi、Mabuchi Tomotaka、Ueda Mahoko Takahashi、Nakagawa So、 SBahram Seiamak、Takehara Kazuhiko、Sato Shinichi、Ihn Hironobu
  • Journal Title: Journal of Investigative Dermatology Volume: 137 Issue: 9 Pages: 1878-1886
  • DOI: 10.1016/j.jid.2017.04.028
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Treatment of psoriasis with ustekinumab improved skin tightening in systemic sclerosis. (2017)
  • Author(s): Ichihara A, Jinnin M, Ihn H.
  • Journal Title: Clin Exp Rheumatol. Volume: 106 Pages: 208-210
  • Peer Reviewed
• [Journal Article] Transforming growth factor β inhibitor Repsox down-regulates collagen expression of scleroderma dermal fibroblasts and prevents bleomycin-induced mice skin fibrosis. (2017)
  • Author(s): Ide M, Jinnin M, Tomizawa Y, Wang Z, Kajihara I, Fukushima S, Hashizume Y, Asano Y, Ihn H.
  • Journal Title: Exp Dermatol Volume: 印刷中 Issue: 11 Pages: 1139-1143
  • DOI: 10.1111/exd.13366
  • Peer Reviewed
• [Journal Article] Early phase dynamics of traceable mCherry fluorescent protein-carrying HIV-1 infection in human peripheral blood mononuclear cells-transplanted NOD/SCID/Jak3 -/- mice (2017)
  • Author(s): Higashi-Kuwata Nobuyo、Ogata-Aoki Hiromi、Hattori Shin-ichiro、Hayashi Hironori、Danish Matthew、Aoki Manabu、Shiotsu Chiemi、Kawamura Tatsuyoshi、Ihn Hironobu、Kobayashi Hisataka、Okada Seiji、Mitsuya Hiroaki
  • Journal Title: Antiviral Research Volume: 144 Pages: 83-92
  • DOI: 10.1016/j.antiviral.2017.03.027
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Serum levels of genomic DNA of α1(I) collagen are elevated in scleroderma patients. (2017)
  • Author(s): Sawamura S, Jinnin M, Shimbara M, Nakamura K, Kudo H, Inoue K, Nakayama W, Kajihara I, Fukushima S, Ihn H.
  • Journal Title: J Dermatol. Volume: 印刷中 Issue: 8 Pages: 927-931
  • DOI: 10.1111/1346-8138.13838
  • Peer Reviewed
• [Journal Article] Cutaneous spindle cell adenolipoma on the nose: A rare variant of lipoma. (2017)
  • Author(s): Sawamura S, Kajihara I, Jinnin M, Honda Y, Ihn H
  • Journal Title: J Dermatol. Volume: 印刷中 Issue: 7
  • DOI: 10.1111/1346-8138.13826
  • Peer Reviewed
• [Journal Article] Efficacy and safety of nivolumab in Japanese patients with previously untreated advanced melanoma: A phase II study (2017)
  • Author(s): Yamazaki Naoya、Kiyohara Yoshio、Uhara Hisashi、Uehara Jiro、Fujimoto Manabu、Takenouchi Tatsuya、Otsuka Masaki、Uchi Hiroshi、Ihn Hironobu、Minami Hironobu
  • Journal Title: Cancer Sci Volume: 108 Issue: 6 Pages: 1223-1230
  • DOI: 10.1111/cas.13241
  • Peer Reviewed / Open Access
• [Journal Article] Transethnic meta-analysis identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis. (2017)
  • Author(s): Terao C, Kawaguchi T, Dieude P, Varga J, Kuwana M, Hudson M, Kawaguchi Y, Matucci-Cerinic M, Ohmura K, Riemekasten G, Kawasaki A, Airo P, Horita T, Oka A, Hachulla E, Yoshifuji H, Caramaschi P, Hunzelmann N, Baron M, Atsumi T, Hassoun P, Torii T, Takahashi M, et al.
  • Journal Title: Ann Rheum Dis. Volume: 印刷中 Issue: 6 Pages: 1150-1158
  • DOI: 10.1136/annrheumdis-2016-210645
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Multiple subcutaneous Candida abscesses on the palm and finger in an immunocompetent patient (2017)
  • Author(s): Noguchi Hiromitsu、Hiruma Masataro、Matsumoto Tadahiko、Yaguchi Takashi、Tashima Hikaru、Ihn Hironobu
  • Journal Title: The Journal of Dermatology Volume: 44 Issue: 7
  • DOI: 10.1111/1346-8138.13818
  • Peer Reviewed
• [Journal Article] Fungal melanonychia: Ungual phaeohyphomycosis caused by Botryosphaeria dothidea (2017)
  • Author(s): Noguchi H、Hiruma M、Matsumoto T、Kano R、Tanaka M、Yaguchi T、Sonoda K、Ihn H
  • Journal Title: Acta Derm Venereol. Volume: 97 Issue: 6 Pages: 765
  • DOI: 10.2340/00015555-2647
  • Peer Reviewed
• [Journal Article] Phase 1b study of pembrolizumab (MK-3475; anti-PD-1 monoclonal antibody) in Japanese patients with advanced melanoma (KEYNOTE-041) (2017)
  • Author(s): Yamazaki Naoya、Takenouchi Tatsuya、Fujimoto Manabu、Ihn Hironobu、Uchi Hiroshi、Inozume Takashi、Kiyohara Yoshio、Uhara Hisashi、Nakagawa Kazuhiko、Furukawa Hiroshi、Wada Hidefumi、Noguchi Kazuo、Shimamoto Takashi、Yokota Kenji
  • Journal Title: Cancer Chemotherapy and Pharmacology Volume: 79 Issue: 4 Pages: 651-660
  • DOI: 10.1007/s00280-016-3237-x
  • Peer Reviewed
• [Journal Article] Cytokine biomarkers to predict antitumor responses to nivolumab suggested in a phase 2 study for advanced melanoma (2017)
  • Author(s): Yamazaki Naoya、Kiyohara Yoshio、Uhara Hisashi、Iizuka Hajime、Uehara Jiro、Otsuka Fujio、Fujisawa Yasuhiro、Takenouchi Tatsuya、Isei Taiki、Iwatsuki Keiji、Uchi Hiroshi、Ihn Hironobu、Minami Hironobu、Tahara Hideaki
  • Journal Title: Cancer Sci. Volume: 108 Issue: 5 Pages: 1022-1031
  • DOI: 10.1111/cas.13226
  • Peer Reviewed / Open Access
• [Journal Article] Subcutaneous cystic phaeohyphomycosis due to Pleurostomophora richardsiae (2017)
  • Author(s): Noguchi Hiromitsu、Hiruma Masataro、Matsumoto Tadahiko、Yaguchi Takashi、Sano Ayako、Mitsui Norikazu、Watanabe Shinichiro、Ihn Hironobu
  • Journal Title: The Journal of Dermatology Volume: 44 Issue: 4
  • DOI: 10.1111/1346-8138.13765
  • Peer Reviewed
• [Journal Article] Achieved good response of S-1 and docetaxel combination chemotherapy in two patients with metastatic extramammary Paget's disease. (2017)
  • Author(s): Egashira S, Kajihara I, Kanemaru H, Uemura-Kiyohara M, Yamada-Kanazawa S, Nakahara S, Nagamoto E, Fukushima S, Jinnin M, Inoue Y, Ihn H.
  • Journal Title: J Dermatol. Volume: 44 Issue: 5
  • DOI: 10.1111/1346-8138.13693
  • Peer Reviewed
• [Journal Article] Bromoderma in a pituitary adenoma patient treated with bromocriptine. (2017)
  • Author(s): Maeda S, Kajihara I, Ogata A, Johno T, Jinnin M, Ihn H.
  • Journal Title: J Dermatol. Volume: 44 Issue: 5 Pages: 95-96
  • DOI: 10.1111/1346-8138.13683
  • Peer Reviewed
• [Journal Article] Efficacy and safety of ixekizumab treatment for Japanese patients with moderate to severe plaque psoriasis, erythrodermic psoriasis and generalized pustular psoriasis: Results from a 52-week, open-label, phase 3 study (UNCOVER-J) (2017)
  • Author(s): Saeki Hidehisa、Nakagawa Hidemi、Nakajo Ko、Ishii Taeko、Morisaki Yoji、Aoki Takehiro、Cameron Gregory S.、Osuntokun Olawale O.、the Japanese Ixekizumab Study Group
  • Journal Title: The Journal of Dermatology Volume: 44 Issue: 4 Pages: 355-362
  • DOI: 10.1111/1346-8138.13622
  • Peer Reviewed
• [Journal Article] Ungual aspergillosis successfully treated with topical efinaconazole (2017)
  • Author(s): Noguchi Hiromitsu、Hiruma Masataro、Matsumoto Tadahiko、Kano Rui、Ihn Hironobu
  • Journal Title: The Journal of Dermatology Volume: 44 Issue: 7 Pages: 848
  • DOI: 10.1111/1346-8138.13543
  • Peer Reviewed
• [Journal Article] Systemic lupus erythematosus associated with myasthenia gravis, pemphigus foliaceus and chronic thyroiditis after thymectomy. (2017)
  • Author(s): Sawamura S, Kajihara I, Makino K, Makino T, Fukushima S, Jinnin M, Oyama B, Hashimoto T, Ihn H.
  • Journal Title: Australas J Dermatol. Volume: 印刷中 Issue: 3
  • DOI: 10.1111/ajd.12510
  • Peer Reviewed
• [Journal Article] Ungual hyalohyphomycosis caused by Fusarium proliferatum in an immunocompetent patient (2017)
  • Author(s): Noguchi Hiromitsu、Hiruma Masataro、Matsumoto Tadahiko、Kano Rui、Ihn Hironobu
  • Journal Title: The Journal of Dermatology Volume: 44 Issue: 1 Pages: 88
  • DOI: 10.1111/1346-8138.13570
  • Peer Reviewed
• [Journal Article] AT-rich Interaction Domain-containing Protein 3B is a New Tumour Marker for Melanoma. (2017)
  • Author(s): Nakahara S, Fukushima S, Yamashita J, Kubo Y, Tokuzumi A, Miyashita A, Harada M, Nakamura K, Jinnin M, Ihn H.
  • Journal Title: Acta Derm Venereol. Volume: 1 Issue: 1 Pages: 112-114
  • DOI: 10.2340/00015555-2449
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Safety and tolerability of bosentan for digital ulcers in Japanese patients with systemic sclerosis: Prospective, multicenter, open-label study (2017)
  • Author(s): Hamaguchi Yasuhito、Sumida Takayuki、Kawaguchi Yasushi、Ihn Hironobu、Tanaka Sumiaki、Asano Yoshihide、Motegi Sei-ichiro、Kuwana Masataka、Endo Hirahito、Takehara Kazuhiko
  • Journal Title: The Journal of Dermatology Volume: 44 Issue: 1 Pages: 13-17
  • DOI: 10.1111/1346-8138.13497
  • Peer Reviewed
• [Journal Article] Diagnosis of nail psoriasis: evaluation of nail-derived microRNAs as potential novel biomarkers. (2017)
  • Author(s): Wang Z, Jinnin M, Harada M, Kudo H, Inoue K, Nakayama W, Honda N1, Makino K1, Kajihara I, Fukushima S, Ihn H
  • Journal Title: European Journal of Dermatology Volume: 1 Issue: 1 Pages: 20-27
  • DOI: 10.1684/ejd.2016.2906
  • Peer Reviewed
• [Journal Article] Inhibition of HSP90 exerts anti-tumor effect on angiosarcoma: Involvement of VEGF signaling pathway. (2017)
  • Author(s): Yamada-Kanazawa S, Kajihara I, Fukushima S, Jinnin M, Masuzawa M, Masuzawa M, Amoh Y, Hoshina D, Abe R, Ihn H.
  • Journal Title: Br J Dermatol. Volume: 印刷中 Issue: 2 Pages: 456-469
  • DOI: 10.1111/bjd.15303
  • Peer Reviewed
• [Journal Article] Adjuvant Nivolumab versus Ipilimumab in Resected Stage III or IV Melanoma (2017)
  • Author(s): Weber Jeffrey、Mandala Mario、Del Vecchio Michele、、Rutkowski Piotr、Yokota Kenji、Yamazaki Naoya、Kim Tae M.、de Pril Veerle、Sabater Javier、Qureshi Anila、Larkin James、Ascierto Paolo A.
  • Journal Title: New England Journal of Medicine Volume: 377 Issue: 19 Pages: 1824-1835
  • DOI: 10.1056/nejmoa1709030
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Fluorescence in situ hybridization for diagnosis of malignant melanoma using RREB1 , MYB , Cep6 , and CCND1 probes in Japanese patients (2017)
  • Author(s): Aoi Jun、Fukushima Satoshi、Jinnin Masatoshi、Ihn Hironobu
  • Journal Title: Dermatologica Sinica, Volume: 35 Issue: 4 Pages: 213-214
  • DOI: 10.1016/j.dsi.2017.04.002
  • Peer Reviewed / Open Access
• [Journal Article] Bullous dermatosis on legs of elderly: A new clinical entity? (2017)
  • Author(s): Ishibashi Takayuki、Jinnin Masatoshi、Kajihara Ikko、Fukushima Satoshi、Ihn Hironobu
  • Journal Title: Drug Discoveries & Therapeutics Volume: 11 Issue: 6 Pages: 346-348
  • DOI: 10.5582/ddt.2017.01067
  • NAID: 130006308074
  • ISSN: 1881-7831, 1881-784X
  • Peer Reviewed
• [Journal Article] Anorectal malignant melanoma with extensive intraepithelial extension: report of a case. (2017)
  • Author(s): Umezaki N, Ishimoto T, Koba I, Nakaya T, Mawatari M, Kuramoto K, Izumi D, Sakamoto Y, Miyamoto Y, Yoshida N, Watanabe M, Inoue Y, Ihn H, Baba H.
  • Journal Title: Int Canc Conf J Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Expression of aurora kinase A in dermatofibrosarcoma protuberans. (2017)
  • Author(s): Kanamori S, Kajihara I, Kanazawa-Yamada S, Otsuka-Maeda S, Ihn H.
  • Journal Title: J Dermatol, Volume: 印刷中
  • Peer Reviewed
• [Journal Article] A randomized double-blind trial of intravenous (2016)
  • Author(s): Amagai M, Ikeda S, Hashimoto T, Mizuashi M, Fujisawa A, Ihn H, Matsuzaki Y, Ohtsuka M, Fujiwara H, Furuta J, Tago O, Yamagami J, Tanikawa A, Uhara H, Morita A, Nakanishi G, Tani M, Aoyama Y, Makino E, Muto M, Manabe M, et al.
  • Journal Title: J Dermatol Sci Volume: 85（2） Issue: 2 Pages: 77-84
  • DOI: 10.1016/j.jdermsci.2016.11.003
  • Peer Reviewed / Open Access
• [Journal Article] Dysregulated interleukin-23 signalling contributes to the increased collagen production in scleroderma fibroblasts via balancing microRNA expression. (2016)
  • Author(s): Nakayama W, Jinnin M, Tomizawa Y, Nakamura K, Kudo H, Inoue K, Makino K, Honda N, Kajihara I, Fukushima S, Ihn H.
  • Journal Title: Rheumatology (Oxford) Volume: 56 Issue: 1 Pages: 145-155
  • DOI: 10.1093/rheumatology/kew336
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The expression of miR-124 increases in aged skin to cause cell senescence and it decreases in squamous cell carcinoma (2016)
  • Author(s): Harada M, Jinnin M, Wang Z, Hirano A, Tomizawa Y, Kira T, Igata T, Masuguchi S, Fukushima S, Ihn H.
  • Journal Title: BioScience Trends Volume: 10 Issue: 6 Pages: 454-459
  • DOI: 10.5582/bst.2016.01102
  • NAID: 130005295759
  • ISSN: 1881-7815, 1881-7823
  • Peer Reviewed
• [Presentation] 乳房外Paget病における血清cell free DNA濃度の意義 (2019)
  • Author(s): 梶原一亨、Mijiddorj Tselmeg、尹 浩信
  • Organizer: Liquid Biopsy研究会
• [Presentation] 全身性強皮症に対するトシリズマブの有効性と安全性：ランダム化プラセボ対照第Ⅲ相臨床試験（focuSSced）結果のフィードバック (2019)
  • Author(s): 嶋 良仁、渥美達也、高橋裕樹、石井智徳、浅野善英、川口鎮司、桑名正隆、山崎宜興、安岡秀剛、石川 治、小寺雅也、竹原和彦、田中良哉、尹 浩信、山下勝久。
  • Organizer: 平成30年度厚生労働科学研究費補助金 難治性疾患等政策研究事業研究班・第22回強皮症研究会議合同会議
• [Presentation] 全身性強皮症の皮膚硬化モデルマウスにおける抗CTGF抗体の効果の検討 (2019)
  • Author(s): 牧野雄成、Maria Trojanowska, 尹 浩信。
  • Organizer: 平成30年度厚生労働科学研究費補助金 難治性疾患等政策研究事業研究班・第22回強皮症研究会議合同会議
• [Presentation] 上皮間葉転換を抑制する化合物Xの新規抗線維化薬としての可能性について (2019)
  • Author(s): 宇都宮彗、知野剛直、Vu Huy Luong、尾山徳孝、長谷川稔、丹羽眞一郎、大塚雅巳、尹 浩信。
  • Organizer: 平成30年度厚生労働科学研究費補助金 難治性疾患等政策研究事業研究班・第22回強皮症研究会議合同会議
• [Presentation] 班研究およびAMED研究の現状について (2019)
  • Author(s): 尹 浩信
  • Organizer: 平成30年度厚生労働科学研究費補助金 難治性疾患等政策研究事業研究班・第22回強皮症研究会議合同会議
• [Presentation] 皮膚線維芽細胞におけるIL-23によるI型コラーゲン発現制御の機序について (2019)
  • Author(s): 中山若菜、神人正寿、尹 浩信
  • Organizer: 平成30年度厚生労働科学研究費補助金 難治性疾患等政策研究事業研究班・第22回強皮症研究会議合同会議
• [Presentation] 全身性強皮症における皮膚組織中のCXCL9、CXCL10の発現 (2019)
  • Author(s): 押川由佳、牧野貴充、牧野雄成、尹 浩信。
  • Organizer: 平成30年度厚生労働科学研究費補助金 難治性疾患等政策研究事業研究班・第22回強皮症研究会議合同会議
• [Presentation] 強皮症における日本人特異的疾患感受性HLA領域の同定 (2019)
  • Author(s): 寺尾知可史、小寺雅也、斎藤和義、川口鎮司、赤星光輝、牧野貴充、中野和久、高木香恵、宇都宮 慧、藤本 学、牧野雄成、、尹 浩信、佐藤伸一、竹原和彦、新納宏昭、田中良哉、桑名正隆、松田文彦、Yannick Allanore、岡田随象、松尾恵太郎、大村浩一郎、三森経世。
  • Organizer: 平成30年度厚生労働科学研究費補助金 難治性疾患等政策研究事業研究班・第22回強皮症研究会議合同会議
• [Presentation] 各種化学療法を施行した頭部脈管肉腫の1例 (2019)
  • Author(s): 山下智香、梶原一亨、尹 浩信
  • Organizer: 第15回加齢皮膚医学研究会
• [Presentation] 肝移植後ミコフェノール酸モフェチル内服中でアプレミラストが奏効した尋常性乾癬の1例 (2019)
  • Author(s): 福岡聖菜、梶原一亨、尹 浩信
  • Organizer: 第226回日本皮膚科学会熊本地方会
• [Presentation] 脊髄損傷患者の難治性尾骨部褥瘡に対してエタノール硬化療法を施行した症例 (2019)
  • Author(s): 石橋卓行、梶原一亨、伊方敏勝、尹 浩信
  • Organizer: 第226回日本皮膚科学会熊本地方会
• [Presentation] 診断、治療に難渋した抗BP180型粘膜類天疱瘡の1例 (2019)
  • Author(s): 田中憲一郎、本多教稔、小林温子、牧野雄成、牧野貴充、尹 浩信。
  • Organizer: 第226回日本皮膚科学会熊本地方会
• [Presentation] The novel diagnostic system to distinguish melanoma from nevus using droplet digital PCR (2018)
  • Author(s): Tsuruta-Kadohisa M, Fukushima S, Miyashita A, Aoi J, Kubo Y, Nakahara S, Kuriyama H, Kimura T, Ihn H.
  • Organizer: International Investigative Dermatology
  • Int'l Joint Research
• [Presentation] Pretreatment serum CTLA-4 is a potential biomarker of a risk of immune-related adverse events in metastatic melanoma. (2018)
  • Author(s): Miyashita A, Fukushima S, Nakahara S, Kubo Y, Tokuzumi A, Tsuruta-Kadohisa M, Kimura T, Kuriyama H, Ihn H.
  • Organizer: International Investigative Dermatology
  • Int'l Joint Research
• [Presentation] 喉頭炎、声帯麻痺を合併したSweet`s disease (2018)
  • Author(s): 宮村智裕、梶原一亨、牧野雄成、尹浩信
  • Organizer: 第117回日本皮膚科学会総会
• [Presentation] 関節症性乾癬患者を対象としたadalimumabの有用性の検討 (2018)
  • Author(s): 西田絵美、森田明理、小川英作、奥山隆平、加藤則人、益田浩司、立石千晴、鶴田大輔、牧野貴充、尹 浩信
  • Organizer: 第117回日本皮膚科学会総会
• [Presentation] 関節リウマチ、糖尿病、末梢動脈閉塞、深部静脈血栓症、皮膚血管炎による難治性皮膚潰瘍の1例 (2018)
  • Author(s): 金子彰良、新森大祐、市原麻子、藤松昴一郎、尹 浩信
  • Organizer: 第117回日本皮膚科学会総会
• [Presentation] イミキモドが奏効した顔面扁平上皮癌の1例 (2018)
  • Author(s): 池田 勇、尹 浩信
  • Organizer: 第117回日本皮膚科学会総会
• [Presentation] エトポシド、モガムリズマブが奏功した末梢性T細胞リンパ腫、非特異型の１例 (2018)
  • Author(s): 石松翔子、梶原一亨、城野剛充、立津 央、尹浩信
  • Organizer: 第117回日本皮膚科学会総会
• [Presentation] 皮膚生検後に消退した皮膚原発びまん性大細胞型B細胞リンパ腫下肢型の1例 (2018)
  • Author(s): 島田佳奈子、福島 聡、江頭 翔、尹浩信、立津 央
  • Organizer: 第117回日本皮膚科学会総会
• [Presentation] 病変の一部に対する電気凝固療法を契機に全体が消退した尖圭コンジローマの1例 (2018)
  • Author(s): 川野勇歩、江川清文、尹 浩信
  • Organizer: 第117回日本皮膚科学会総会
• [Presentation] Fusarium petroliphilumによる趾間びらん症 (2018)
  • Author(s): 廣瀬美希、野口博光、比留間政太郎、松本忠彦、福島 聡、尹 浩信
  • Organizer: 第117回日本皮膚科学会総会
• [Presentation] 乳房外パジェット病におけるCDK4蛋白質発現の検討 (2018)
  • Author(s): 浦田和美、梶原一亨、大塚沙希、金澤早織、牧野雄成、青井 淳、牧野貴充、福島 聡、神人正寿、尹 浩信。
  • Organizer: 第117回日本皮膚科学会総会
• [Presentation] Serum levels of soluble programmed death-ligand 1 in patients with metastatic melanoma treated with anti-programmed death-ligand 1 antibodies. (2018)
  • Author(s): Fukushima S, Inamori Y, Kubo Y, Nakahara S, Miyashita A, Kadoshita M, Tokuzumi A, Masuguchi S, Niimori D, Jinnin M, Ihn H.
  • Organizer: The 13 th Meeting og German-Japanese Society of Dermatology
  • Int'l Joint Research
• [Presentation] Long-term observation of dermoscopic findings in patients with infantile hemangioma. EADC (2018)
  • Author(s): Jinnin M, Fukushima S, Ihn H.
  • Organizer: East Asia Dermatology Congress
• [Presentation] 全身性強皮症の線維化病態に対してplatelet-derived growth factor receptor (PDGFR)阻害剤が与える影響の検討 Effects of platelet-derived growth factor receptor (PDGFR) inhibitor for the fibrosis of systemic sclerosis (2018)
  • Author(s): 牧野雄成、Maria Trojanowska、尹 浩信
  • Organizer: 第50回日本結合組織学会
• [Presentation] 多剤免疫抑制療法にて救命しえた急速進行性間質性肺炎を合併した無筋性皮膚筋炎の1例 (2018)
  • Author(s): 坂元亮子、宮下 梓、久保正英、尹 浩信
  • Organizer: 第14回日本皮膚科学会南九州地区合同地方会
• [Presentation] 転写因子BATF2のIL-12p40発現促進による抗腫瘍効果について (2018)
  • Author(s): 金丸 央、佐藤 荘、福島 聡、尹 浩信、審良静男
  • Organizer: 第34回日本皮膚悪性腫瘍学会学術大会
• [Presentation] 上口唇、咽頭に多発した原発悪性黒色腫の1例 (2018)
  • Author(s): 水橋 覚、宮下 梓、福島 聡、尹 浩信
  • Organizer: 第34回日本皮膚悪性腫瘍学会学術大会
• [Presentation] 治療に難渋した免疫チェックポイント阻害薬による腸炎の2例 (2018)
  • Author(s): 宮下 梓、福島 聡、宮村智裕、山下智香、宮本英明、尹 浩信
  • Organizer: 第34回日本皮膚悪性腫瘍学会学術大会
• [Presentation] 日本人進行期悪性黒色腫患者を対象としたペンブロリズマブの第Ib相試験の最終解析 (2018)
  • Author(s): 藤澤康弘、横田憲二、竹之内辰也、尹 浩信、内 博史、猪爪隆史、清原祥夫、宇原 久、山﨑直也
  • Organizer: 第34回日本皮膚悪性腫瘍学会学術大会
• [Presentation] 根治切除不能な化学療法未治療の悪性黒色腫を対象としたニボルマブ国内第II相試験（ONO-4538-08）長期追跡 (2018)
  • Author(s): 清原祥夫、山﨑直也、宇原 久、上原治朗、藤本 学、竹之内辰也、大塚正樹、内 博史、尹 浩信、南 博信。
  • Organizer: 第34回日本皮膚悪性腫瘍学会学術大会
• [Presentation] ステージIII悪性黒色腫に対するペンブロリズマブ術後補助療法の第3相試験（EROTC1325/KEYNOTE-054）の日本人集団解析 (2018)
  • Author(s): 山﨑直也、横田憲二、清原祥夫、猪爪隆史、尹 浩信、竹之内辰也、 Stefan Suciu、Alexander Eggermont
  • Organizer: 第34回日本皮膚悪性腫瘍学会学術大会
• [Presentation] 腫瘍関連マクロファージにおける転写因子BATF2のIL-12p40発現促進による抗腫瘍効果 (2018)
  • Author(s): 金丸 央、佐藤 荘、福島 聡、尹 浩信、審良 静男
  • Organizer: 第22回日本がん免疫学総会
• [Presentation] 血清可溶性PD-L1濃度のメラノーマ患者における検討 (2018)
  • Author(s): 福島 聡、稲森有貴子、久保陽介、中原智史、宮下 梓、鶴田美菜、徳澄亜紀、新森大祐、熊井良彦、高村晴香、折井頼尚、尹 浩信
  • Organizer: 第22回日本がん免疫学総会
• [Presentation] 全身性強皮症の過剰なI型コラーゲン産生におけるマイクロRNA let-7aの役割の検討 The role of microRNA let-7a to the excessive production of type I collagen in systemic sclerosis (2018)
  • Author(s): 牧野雄成、神人正寿、尹 浩信
  • Organizer: 第10回日本RNAi研究会
• [Presentation] 心不全を伴う膿疱性乾癬にイキセキズマブを投与し著効した1例 (2018)
  • Author(s): 宮下加奈子、本多教稔、梶原一亨、尹 浩信
  • Organizer: 第33回日本乾癬学会
• [Presentation] 透析シャント部位に一致してケブネル現象をきたした膿疱性乾癬の1例 (2018)
  • Author(s): 渡邉千夏、梶原一亨、尹 浩信
  • Organizer: 第33回日本乾癬学会
• [Presentation] メラノーマ患者における血清可溶性PD-L1濃度の検討 (2018)
  • Author(s): 福島 聡、稲森有貴子、久保陽介、中原智史、宮下 梓、新森大祐、尹 浩信
  • Organizer: 第90回日本皮膚科学会山梨地方会（島田眞路日本皮膚科学会理事長退任記念地方会）
• [Presentation] 扁平苔癬型薬疹の1例 (2018)
  • Author(s): 中島聡子、宮下 梓、谷川広紀、工藤英郎、神人正寿、尹 浩信。
  • Organizer: 日本皮膚科学会第224回熊本地方会
• [Presentation] 褥瘡予防ケア推進のための体制整備と要因分析教育の効果（第2報） (2018)
  • Author(s): 増田未散、本多教稔、宮下 梓、尹 浩信。
  • Organizer: 第20回日本褥瘡学会学術集会
• [Presentation] Topline results from phase II of combination treatment with canerpaturev (HF10), an oncolytic viral immunotherapy, and ipilimumab in patients with unresectable or metastatic melanoma after anti-PD-1 therapy. (2018)
  • Author(s): Isei T, Yokota K, Uhara H, Fujisawa Y, Takenouchi T, Kiyohara Y, Uchi H, Saruta H, Ihn H, Inozume T, Watanabe D, Takahashi A, Fukushima S, Tanaka M, Y amazaki N.
  • Organizer: ESMO 2018
• [Presentation] 担がん個体におけるIL-6シグナルを介したTh1応答抑制とその解除療法の奏功 (2018)
  • Author(s): 西村泰治、藤枝浩司、宮下 梓、福島 聡、池田徳典、久保陽介、千住 覚、尹 浩信、押海裕之、塚本博丈
  • Organizer: 第46回日本臨床免疫学会総会
• [Presentation] 乳房外パジェット病におけるCDK4蛋白質発現の検討 (2018)
  • Author(s): 浦田和美、梶原一亨、大塚紗季、金澤早織、牧野雄成、青井 淳、牧野貴充、福島 聡、神人正寿、尹 浩信
  • Organizer: 第46回日本臨床免疫学会総会
• [Presentation] 抗PD-1抗体のバイオマーカーとしての血清PD-L1濃度の検討 (2018)
  • Author(s): 稲森有貴子、福島 聡、久保陽介、中原智史、宮下 梓、鶴田美菜、徳済亜紀、新森大祐、藤井良彦、高村晴香、折田頼尚、尹 浩信
  • Organizer: 第46回日本臨床免疫学会総会
• [Presentation] リナグリプチン内服中に生じた限局性類天疱瘡の1例 (2018)
  • Author(s): 宮下加奈子、梶原一亨、尹 浩信、石井文人、橋本 隆
  • Organizer: 第70回日本皮膚科学会西部支部学術大会
• [Presentation] 手術により救命し得た創傷型ビブリオ感染症による壊死性筋膜炎の1例 (2018)
  • Author(s): 中原智史、城野剛充、牧野公治、牧野貴充、境 恵祐、福島 聡、尹 浩信、土田 徹
  • Organizer: 第70回日本皮膚科学会西部支部学術大会
• [Presentation] 突然の胸痛を認めた、心筋障害を合併したoverlap症候群の1例 (2018)
  • Author(s): 金子彰良、梶原一亨、宮下 梓、尹 浩信
  • Organizer: 第70回日本皮膚科学会西部支部学術大会
• [Presentation] 当科における血管肉腫の臨床的検討 (2018)
  • Author(s): 坂元亮子、梶原一亨、大塚紗季、金澤早織、尹 浩信
  • Organizer: 第70回日本皮膚科学会西部支部学術大会
• [Presentation] 悪性腫瘍の治療のみでは不十分でステロイド導入に至った卵巣癌合併の皮膚筋炎の1例 (2018)
  • Author(s): 中島聡子、宮下 梓、木村俊寛、栗山春香、山下智香、神人正寿、大岡大社、斉藤文誉、田代浩徳、尹 浩信
  • Organizer: 第70回日本皮膚科学会西部支部学術大会
• [Presentation] 漿液性網膜剥離を伴ったSLEの1例 (2018)
  • Author(s): 渡邉千夏、宮下 梓、牧野雄成、尹 浩信
  • Organizer: 第70回日本皮膚科学会西部支部学術大会
• [Presentation] Roles of platelet-derived growth factor receptor (PDGFR) for the fibrosis of systemic sclerosis. 全身性強皮症の線維化に対してplatelet-derived growth factor receptor (PDGFR)阻害剤が与える影響の検討。 (2018)
  • Author(s): Katsunari Makino, Maria Trojanowska, Ihn H
  • Organizer: 第41回日本分子生物学会年会
• [Presentation] 大腿外側に生じた巨大なchronic expanding hematomaの2例 (2018)
  • Author(s): 島田佳奈子、牧野雄成、江頭 翔、伊方敏勝、増口信一、尹 浩信
  • Organizer: 日本皮膚科学会第225回熊本地方会
• [Presentation] 40歳代女性の背部に生じたbullous morpheaの1例 (2018)
  • Author(s): 丸田志野、牧野雄成、青井 淳、尹 浩信
  • Organizer: 日本皮膚科学会第225回熊本地方会
• [Presentation] エフィコナゾール爪外用液による爪白癬の治療 (2018)
  • Author(s): 野口博光、松本忠彦、比留間政太郎、浅尾香恵、福島 聡、尹 浩信
  • Organizer: 日本皮膚科学会第225回熊本地方会
• [Presentation] アナフィラキシー症状を呈した減汗性コリン性蕁麻疹の1例 (2018)
  • Author(s): 永野美和、中山若菜、本多教稔、福島 聡、尹 浩信、山川詩織、中根俊成。
  • Organizer: 日本皮膚科学会第225回熊本地方会
• [Presentation] 全身性強皮症エクソーム解析 (2018)
  • Author(s): 岡 晃、石川 治、竹原和彦、藤本 学、長谷川 稔、桑名正隆、川口鎮司、山本俊幸、高橋裕樹、後藤大輔、佐藤伸一、浅野善英、遠藤平仁、神人正寿、尹 浩信
  • Organizer: 厚生労働省「強皮症・皮膚線維化疾患の診断基準・重症度分類・診療ガイドラインに関する研究」研究班2017年度班会議・第21回強皮症研究会議
• [Presentation] 本邦における全身性強皮症早期重症例の臨床症状の推移：多施設前向き研究 (2018)
  • Author(s): 宇都宮 彗、長谷川 稔、浅野善英、石川 治、遠藤平仁、小川文秀、川口鎮司、桑名正隆、後藤大輔、佐藤伸一、高橋裕樹、竹原和彦、田中住明、藤本 学、尹 浩信
  • Organizer: 厚生労働省「強皮症・皮膚線維化疾患の診断基準・重症度分類・診療ガイドラインに関する研究」研究班2017年度班会議・第21回強皮症研究会議
• [Presentation] 皮膚画像解析ソフト（VISIA-Evolution&reg;）を用いた全身性強皮症患者の顔面皮膚の状態の解析 (2018)
  • Author(s): 澤村創一郎、牧野雄成、神人正寿、尹 浩信
  • Organizer: 厚生労働省「強皮症・皮膚線維化疾患の診断基準・重症度分類・診療ガイドラインに関する研究」研究班2017年度班会議・第21回強皮症研究会議
• [Presentation] 成人限局性強皮症の新規簡易日常生活動作障害スコアリングシステムの有効性 (2018)
  • Author(s): 沖山奈緒子、浅野善英、濱口儒人、神人正寿、茂木精一郎、小泉 遥、長谷川 稔、石川 治、佐藤伸一、竹原和彦、山本俊幸、藤本 学、尹 浩信
  • Organizer: 厚生労働省「強皮症・皮膚線維化疾患の診断基準・重症度分類・診療ガイドラインに関する研究」研究班2017年度班会議・第21回強皮症研究会議
• [Presentation] ニボルマブにより重症筋無力症、筋炎、心筋炎を発症した症例 (2017)
  • Author(s): 福島 聡、木村俊宏、宮下 梓、青井 淳、神人正寿、井上博之、清谷一馬、Jae-Hyun Park、中村祐輔、尹 浩信
  • Organizer: 第86回日本皮膚科学会山梨地方会
• [Presentation] A novel small compound HPH-15 antagonizes TGF-β/Smad signaling and ameliorates experimental skin fibrosis. (2017)
  • Author(s): Luong VH, Chino T, Tokuriki A, Oyama N, Sasaki Y, Ogura D, Niwa S, Fujita M, Okamoto M, Otsuka M, Ihn H, Hasegawa M.
  • Organizer: 76 th Annual Meeting of Society for Investigative Dermatology
  • Int'l Joint Research
• [Presentation] Analysis of the prevalence of fusion oncogenes in cutaneous angiosarcoma. (2017)
  • Author(s): Jinnin M, Shimozono N, Amoh Y, Masuzawa M, Masuzawa M, Fukushima S, Ihn H.
  • Organizer: 76 th Annual Meeting of Society for Investigative Dermatology
  • Int'l Joint Research
• [Presentation] 当院の臀部褥瘡患者における下痢の影響 (2017)
  • Author(s): 野口あかね、園田香奈子、増田未散、三隅彰子、本多教稔、尹 浩信
  • Organizer: 第14回日本褥瘡学会九州・沖縄地方会学術大会
• [Presentation] 頭部巨大有棘細胞癌の頭蓋内浸潤に脳膿瘍を併発した1例 (2017)
  • Author(s): 渡邉千夏、青井 淳、尹 浩信
  • Organizer: 第116回日本皮膚科学会総会
• [Presentation] 当科で経験した骨髄性プロトポルフィリン症の３例 (2017)
  • Author(s): 前原志野、宮下加奈子、新森大祐、宮下 梓、牧野貴充、神人正寿、中野 創、山本栄和、猪股祐紀洋、尹 浩信
  • Organizer: 第116回日本皮膚科学会総会
• [Presentation] 大規模災害におけるメーリングリストの有用性について (2017)
  • Author(s): 池田 勇、牧野貴充、福島 聡、伊方敏勝、神人正寿、尹 浩信
  • Organizer: 第116回日本皮膚科学会総会
• [Presentation] 脊髄炎を合併したSLEに対し、ステロイドパルス療法とシクロホスファミドパルス療法が奏効した1例 (2017)
  • Author(s): 島田佳奈子、梶原一亨、神人正寿、尹 浩信。
  • Organizer: 第116回日本皮膚科学会総会
• [Presentation] 染毛剤の吸入によるアナフィラキシーショックの1例 (2017)
  • Author(s): 福島 聡、緒方亜紀、本多教稔、神人正寿、尹 浩信
  • Organizer: 第66回日本アレルギー学会総会
• [Presentation] Nivolumabによる大腸炎を発症した患者における免疫学的解析 (2017)
  • Author(s): 宮下 梓、福島 聡、塚本博丈、板井久恵、藤枝浩司、西村泰治、宮本英明、尹 浩信
  • Organizer: 第21回日本がん免疫学会総会
• [Presentation] Intratumoral expression levels of PD-L1, GZMA, and HLA-A along with oligoclonal T cell expansion associate with response to nivolmab against melanomas. (2017)
  • Author(s): Fukushima S, Inoue H, Park JH, Kiyotani K, Zewde M, Miyashita A, Jinnin M, Kiniwa Y, Okuyama R, Tanaka R, Fujisawa Y, Kato H, Morita A, Asai J, Katoh N, Yokota K, Akiyama M, Ihn H, Nakamura Y.
  • Organizer: 第21回日本がん免疫学会総会
• [Presentation] IL-15産生iPS細胞由来ミエロイドラインを用いた免疫療法 (2017)
  • Author(s): 久保陽介、福島 聡、鶴田美菜、中原智史、徳澄亜紀、宮下 梓、張 エイ、岩間達章、中面哲也、植村靖史、千住 覚、神人正寿、尹 浩信
  • Organizer: 第21回日本がん免疫学会総会
• [Presentation] 根治切除不能なIII/IV又は再発の化学療法未治療の悪性黒色腫を対象としたニボルマブ国内第II相試験の成績 (2017)
  • Author(s): 清原祥夫、山﨑直也、宇原 久、上原治朗、藤本 学、竹之内辰也、大塚正樹、内 博史、尹 浩信、南 博信
  • Organizer: 第33回日本皮膚悪性腫瘍学会
• [Presentation] KEYNOTE-41:日本人進行性悪性黒色腫患者を対象としたペンブロリズマブの第Ib相試験 (2017)
  • Author(s): 竹之内辰也、横田憲二、藤澤康弘、尹 浩信、内 博史、猪爪隆史、清原祥夫、宇原 久、山﨑直也
  • Organizer: 第33回日本皮膚悪性腫瘍学会
• [Presentation] Nivolumab投与後にリウマチ性多発筋痛症を発症した1例 (2017)
  • Author(s): 宮下 梓、福島 聡、影下雄一、神人正寿、尹 浩信
  • Organizer: 第33回日本皮膚悪性腫瘍学会
• [Presentation] 当院における乳房外Paget病に対するS-1/docetaxel併用療法の検討 (2017)
  • Author(s): 田中憲一郎、梶原一亨、福島 聡、尹 浩信
  • Organizer: 第33回日本皮膚悪性腫瘍学会
• [Presentation] 進展経過を長期間観察し得た爪甲下melanoma in situの2例 (2017)
  • Author(s): 山下智香、影下雄一、宮下 梓、福島 聡、神人正寿、尹 浩信
  • Organizer: 第33回日本皮膚悪性腫瘍学会
• [Presentation] 術後電子線照射を行ったカポジ肉腫様血管内皮細胞腫の一例 (2017)
  • Author(s): 神人正寿、尹 浩信
  • Organizer: 第14回日本血管腫血管奇形学会
• [Presentation] 当院における円形脱毛症に対するステロイドパルス療法の有効性についての検討 (2017)
  • Author(s): 山下智香、神人正寿、石松翔子、宮下 梓、福島 聡、尹 浩信
  • Organizer: 第35回日本美容皮膚科学会
• [Presentation] プロプラノール内服治療を行った消退期の乳児血管腫の1例 (2017)
  • Author(s): 渡邉千夏、神人正寿、藤澤明彦、尹 浩信、天野冨貴子
  • Organizer: 第35回日本美容皮膚科学会
• [Presentation] 治療に難渋した劇症型ざ瘡の1例 (2017)
  • Author(s): 市原麻子、中村香代、島田秀一、牧野貴充、福島聡、神人正寿、尹浩信
  • Organizer: 第35回日本美容皮膚科学会
• [Presentation] インフリキシマブで多発性筋炎を発症した尋常性乾癬の1例 (2017)
  • Author(s): 福島 聡、梶原一亨、宮下 梓、浅尾香恵、藤澤明彦、浅尾香恵、神人正寿、尹 浩信。
  • Organizer: 第32回日本乾癬学会学術大会
• [Presentation] セクキヌマブ加療中に間質性肺炎を発症した尋常性乾癬の1例 (2017)
  • Author(s): 梶原一亨、赤池公考、尹 浩信
  • Organizer: 第32回日本乾癬学会学術大会
• [Presentation] 当院におけるアダリムマブ治療の検討 (2017)
  • Author(s): 渡邉千夏、梶原一亨、市原麻子、尹 浩信
  • Organizer: 第32回日本乾癬学会学術大会
• [Presentation] 乾癬患者血清を用いたエキソソーム測定 (2017)
  • Author(s): 市原麻子、神人正寿、尹 浩信
  • Organizer: 第32回日本乾癬学会学術大会
• [Presentation] 全身性強皮症におけるボセンタンの皮膚潰瘍抑制効果と副作用の検討 (2017)
  • Author(s): 牧野貴充、神人正寿、梶原一亨、牧野雄成、本多教稔、尹 浩信
  • Organizer: 第81回日本皮膚科学会東部支部学術大会
• [Presentation] Immunotherapy against metastatic melanoma with iPS cell-derived myeloid cell lines producing IFN-β or IL-15. (2017)
  • Author(s): Kubo Y, Fukushima S, Nakahara S, Miyasita A, Zhang R, Iwama T, Nakatsura T, Uemura Y, Senju S, Hironobu Ihn.
  • Organizer: 47 th Annual ESDR Meeting 2017
  • Invited
• [Presentation] Immune biomarkers to predict response of nivolimab, intratumoral gene expression and T cell receptor repertoire analysis. (2017)
  • Author(s): Fukushima S, Inoue H, Park J, Kiyotani K, Kiniwa Y, Fujisawa Y, Kato H, Asai J, Yokota K, Ihn H, Nakamura Y.
  • Organizer: 47 th Annual ESDR Meeting 2017
  • Invited
• [Presentation] Serum levels of genomic DNA of α1(I) collagen are detectable and elevated in scleroderma patients (2017)
  • Author(s): Sawamura S, Jinnin M, Shimbara M, Nakamura K, Kudo H, Inoue K, Nakayama W, Kajihara I, Fukushima S, Ihn H.
  • Organizer: 47 th Annual ESDR Meeting 2017
  • Invited
• [Presentation] A novel TGF-β/Smad signaling inhibitor ameliorates bleomycin-induced skin fibrosis. (2017)
  • Author(s): Hasegawa M, Luong VH, Chino T, Oyama N, Sasaki Y, Ogura D, Niwa S, Fujita M, Okamoto Y, Otsuka M, Ihn H.
  • Organizer: 47 th Annual ESDR Meeting 2017
• [Presentation] Secreted protein acidic and rich in Cysteine, a new biomarker of localized scleroderma. (2017)
  • Author(s): Tsuruta M, Fukushima S, Hayano S, Yoshikawa T, Kawabe K, Makino T, Jinnin M, Ihn H.
  • Organizer: 47 th Annual ESDR Meeting 2017
• [Presentation] The antitumor effect of basic leucine zipper transcription factor ATF-like 2 through IL-12 p40 upregulation. (2017)
  • Author(s): Kanemaru H, Satoh T, Fukuhsima S, Ihn H, Akira S.
  • Organizer: 47 th Annual ESDR Meeting 2017
• [Presentation] 全身性強皮症・限局性強皮症・好酸球性筋膜炎・硬化性萎縮性苔癬 診療ガイドライン講習会4「好酸球性筋膜炎」 (2017)
  • Author(s): 山本俊幸、神人正寿、尹 浩信
  • Organizer: 第69回日本皮膚科学会西部支部学術大会
• [Presentation] 当科における難治性皮膚潰瘍に対する再生医療の取り組み (2017)
  • Author(s): 石松翔子、工藤英郎、新森大祐、米村雄士、梶原一亨、牧野雄成、尹 浩信
  • Organizer: 第69回日本皮膚科学会西部支部学術大会
• [Presentation] 免疫チェックポイント阻害薬を使用した悪性黒色腫例の臨床的検討 (2017)
  • Author(s): 栗山春香、福島 聡、木村俊寛、鶴田美菜、久保陽介、徳澄亜紀、中原智史、宮下 梓、神人正寿、尹 浩信
  • Organizer: 第69回日本皮膚科学会西部支部学術大会
• [Presentation] 放射線療法、CA療法が著効し、神経脈管浸潤を伴った鼠径リンパ節転移有棘細胞癌に手術が可能となった1例 (2017)
  • Author(s): 宮下加奈子、伊方敏勝、石橋卓行、増口信一、佐藤広生、坂口 尚、福島 聡、尹 浩信
  • Organizer: 第69回日本皮膚科学会西部支部学術大会
• [Presentation] 当院における乳児血管腫に対するプルプラノール内服療法の検討 (2017)
  • Author(s): 山下智香、神人正寿、尹 浩信
  • Organizer: 第69回日本皮膚科学会西部支部学術大会
• [Presentation] 小型・低価格な顕微鏡カメラの開発 (2017)
  • Author(s): 池田 勇、工藤英郎、山ノ内祥訓、中西義孝、尹 浩信
  • Organizer: 第69回日本皮膚科学会西部支部学術大会
• [Presentation] Botryosphaeria dothideaによる爪黒色菌糸症 (2017)
  • Author(s): 廣瀬美希、野口博光、比留間政太郎、松本忠彦、加納 塁、矢口貴志、田中 勝、尹 浩信
  • Organizer: 第69回日本皮膚科学会西部支部学術大会
• [Presentation] Dysregulated interleukin-37 signaling contributes to the increased collagen production in scleroderma skin (2017)
  • Author(s): Kudo H, Jinnin M, Ihn H
  • Organizer: International Cytokine & Interferon Society 2017
  • Invited
• [Presentation] 健常人に生じたcandida albicansによる多発皮下膿瘍 (2017)
  • Author(s): 廣瀬美希、野口博光、比留間政太郎、松本忠彦、福島 聡、尹 浩信
  • Organizer: 日本皮膚科学会第221回熊本地方会
• [Presentation] 左耳介後部に生じたwarty dyskeratomaの1例 (2017)
  • Author(s): 金子彰良、三宅大我、牧野雄成、市原麻子、尹 浩信
  • Organizer: 日本皮膚科学会第221回熊本地方会
• [Presentation] 脂腺母斑より生じた骨化を伴う基底細胞癌の1例 (2017)
  • Author(s): 草場雄道、青井 淳、牧野雄成、江頭 翔、尹 浩信
  • Organizer: 日本皮膚科学会第221回熊本地方会
• [Presentation] 尋常性乾癬に合併した水疱性類天疱瘡の1例 (2017)
  • Author(s): 水橋 覚、中山若菜、梶原一亨、尹 浩信
  • Organizer: 日本皮膚科学会第221回熊本地方会
• [Presentation] 乳房外パジェット病における5-FU代謝酵素の発現レベル (2017)
  • Author(s): 梶原一亨、尹 浩信
  • Organizer: 2017年度生命科学系学会年次大会
• [Presentation] 全身性強皮症の過剰なI型コラーゲン産生におけるマイクロRNA let-7aの関与の検討 (2017)
  • Author(s): 牧野雄成、神人正寿、尹 浩信
  • Organizer: 2017年度生命科学系学会年次大会第40回日本分子生物学会年会・第40回日本生化学大会
• [Presentation] Serum α1(I) collagen DNA as a potential biomarker for scleroderma patients. (2017)
  • Author(s): Sawamura S, Jinnin M, Shimbara M, Nakamura K, Kudo H, Inoue K, Nakayama W, Kajihara I, Fukushima S, Ihn H.
  • Organizer: 42 th Annual Meeting of the Japanese Society for Investigative Dermatology
• [Presentation] Serum levels of soluble PD-L1 in patients with metastatic melanoma treated with anti-PD-1 antibodies. (2017)
  • Author(s): Fukushima S, Inamori Y, Kubo Y, Nakahara S, Miyashita A, Tsuruta M, Tokuzumi A, Niimori D, Jinnin M, Ihn H.
  • Organizer: 42 th Annual Meeting of the Japanese Society for Investigative Dermatology
• [Presentation] RXRB is a MHC-encoded susceptibility gene associated with anti-topoisomerase I antibody-positive systemic sclerosis. (2017)
  • Author(s): Oka A, Asano Y, Hasegawa M, Fujimoto M, Ishikawa O, Kuwana M, Kawaguchi Y, Yamamoto T, Takahashi H, Goto D, Endo H, Jinnin M, Takehara K, Sato S, Ihn H.
  • Organizer: 42 th Annual Meeting of the Japanese Society for Investigative Dermatology
• [Presentation] 全身性強皮症の線維化病態に対してplatelet-derived growth factor receptor (PDGFR)阻害剤が与える影響の検討 (2017)
  • Author(s): 牧野雄成、Maria Trojanowska、尹 浩信
  • Organizer: 厚生労働省「強皮症・皮膚線維化疾患の診断基準・重症度分類・診療ガイドラインに関する研究」研究班2017年度班会議・第21回強皮症研究会議
• [Presentation] 強皮症マウスモデルを用いた既存化合物LKC0008の抗線維化作用の検討 (2017)
  • Author(s): 小泉 遼、Vu Huy Luong、知野剛直、尾山徳孝、長谷川稔、丹羽眞一郎、大塚雅巳、尹 浩信
  • Organizer: 厚生労働省「強皮症・皮膚線維化疾患の診断基準・重症度分類・診療ガイドラインに関する研究」研究班2017年度班会議・第21回強皮症研究会議
• [Presentation] 全身性強皮症におけるC-X-C motif chemokine ligand 17（CXCL-17）の機能の検討 (2017)
  • Author(s): 島田秀一、牧野雄成、神人正寿、尹 浩信
  • Organizer: 厚生労働省「強皮症・皮膚線維化疾患の診断基準・重症度分類・診療ガイドラインに関する研究」研究班2017年度班会議・第21回強皮症研究会議
• [Book] 創傷・褥瘡・熱傷ガイドライン (2018)
  • Author(s): 公益社団法人 日本皮膚科学会 創傷・褥瘡・熱傷ガイドライン策定委員会
  • Total Pages: 352
  • Publisher: 金原出版
  • ISBN: 9784307400572
• [Book] 診療ガイドラインUO-TO-DATE 2018→2019 (2018)
  • Author(s): 尹浩信
  • Total Pages: 1064
  • Publisher: メディカルレビュー社
  • ISBN: 4779220084
• [Book] 皮膚疾患最新の治療2017-2018 (2017)
  • Author(s): 尹 浩信
  • Total Pages: 336
  • Publisher: 南江堂
  • ISBN: 9784524254163
• [Book] ガイドライン外来診療2017 (2017)
  • Author(s): 尹 浩信
  • Total Pages: 650
  • Publisher: 日経メディカル開発
  • ISBN: 4931400817
• [Book] 膠原病診療のこれまでとこれから。皮膚アレルギーフロンティア (2017)
  • Author(s): 藤本 学、尹 浩信、佐藤伸一
  • Total Pages: 62
  • Publisher: メディカルレビュー社
  • ISBN: 9784779218538
• [Book] 炎症と免疫 (2017)
  • Author(s): 尹浩信
  • Total Pages: 97
  • Publisher: 先端医学社
  • ISBN: 4865502734
• [Book] 臨床免疫・アレルギー科 (2017)
  • Author(s): 尹浩信
  • Publisher: 科学評論社