An attempt to establish immunological diagnostic system using newly cDNA for autoimmune bullous diseases.
| Project/Area Number |
16K10180
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Kurume University |
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Principal Investigator |
ISHII Norito 久留米大学, 医学部, 准教授 (80330827)
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| Co-Investigator(Kenkyū-buntansha) |
大畑 千佳 久留米大学, 医学部, 准教授 (70362712)
古賀 浩嗣 久留米大学, 医学部, 講師 (40461412)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 自己免疫性水疱症 / 皮膚診断学 / 皮膚免疫学 / 蛍光抗体法 / ELISA法 / イムノブロット法 / 免疫ブロット法 |
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| Outline of Final Research Achievements |
Although many new disease entities of autoimmune bullous disease (AIBD) have recently been recognized, satisfactory immunological diagnostic methods and comprehensive classifications for various AIBDs have not been established.
To identify immunological diagnostics and comprehensive classifications for AIBDs in this study. Our immunological diagnostic method is useful for making diagnoses for
most patients with AIBD. However, we need further improvements including new immunological techniques to establish more satisfactory methods.
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| Academic Significance and Societal Importance of the Research Achievements |
自己免疫性水疱症における抗原抗体解析を通して、診断システムの有用性を検討した。自己抗体の病態への関与はいまだ不明な点はあるものの、これらの研究結果は種々の自己免疫性水疱症における正確な診断および適切な治療の選択に有益であり、治療戦略へ発展に寄与したと考える。
適切な治療を行なうことで、速やかな病勢の改善と、医療費の軽減が得られる。この研究の副次的産物として、新しい構成蛋白が同定されることは、基礎的な細胞生物学の発展にも寄与するもので、行政及び社会への貢献度が高い。難治性の自己免疫性水疱症の治療が改善することは、国民の保健・医療・福祉の向上等についても大いに意義のあるものである。
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Report
(4 results)
Research Products
(78 results)
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[Journal Article] 症例 涙道閉塞をきたした抗ラミニン332型粘膜類天疱瘡の1例2018
Author(s)
藤本 裕子, 斎藤 まり, 妹尾 明美, 牧原 亜矢子, 眞部 恵子, 青山 裕美, 西江 渉, 石井 文人, 橋本 隆, 村田 晶子
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Journal Title
皮膚科の臨床
Volume: 60
Issue: 13
Pages: 2023-2028
DOI
NAID
ISSN
0018-1404
Year and Date
2018-12-01
Related Report
Peer Reviewed
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[Journal Article] 特集 水疱症･膿疱症 抗BP180型粘膜類天疱瘡の2例2018
Author(s)
藤井 建人, 高橋 智子, 丹羽 宏文, 水野 雄貴, 松山 かなこ, 周 円, 牧田 浩樹, 有本 幸恵, 石井 文人, 清島 真理子
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Journal Title
皮膚科の臨床
Volume: 60
Issue: 5
Pages: 617-620
DOI
ISSN
0018-1404
Year and Date
2018-05-01
Related Report
Peer Reviewed
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[Journal Article] A case of acquired haemophilia A in a patient with bullous pemphigoid and review of the Japanese literature.2018
Author(s)
Chijiwa C, Kamata M, Fukuyasu A, Shono Y, Takeoka S, Tateishi M, Fukaya S, Hayashi K, Tanaka T, Ishikawa T, Ohnishi T, Saito K, Ishii N, Hashimoto T, Tada Y
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Journal Title
Eur J Dermatol,
Volume: 28
Issue: 3
Pages: 422-423
DOI
Related Report
Peer Reviewed
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[Journal Article] Detection of IgE autoantibodies to BP180 and BP230 and their relationship to clinical features in bullous pemphigoid2017
Author(s)
Hashimoto T, Ohzono A, Teye K, Numata S, Hiroyasu S, Tsuruta D, Hachiya T, Kuroda K, Hashiguchi M, Kawakami T, Ishii N
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Journal Title
Br J Dermatol
Volume: 177(1)
Pages: 141-151
Related Report
Peer Reviewed / Open Access
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[Journal Article] Unique mouse monoclonal antibodies reactive with maturation-related epitopes on type VII collagen2017
Author(s)
Hayakawa T, Hirako Y, Teye K, Tsuchisaka A, Koga H, Ishii N, Karashima T, Kaneda M, Oyu Y, Tateishi C, Sugawara K, Yonamine A, Shinkuma S, Shimizu H, Fukano H, Shimozato K, Nguyen NT, Marinkovich MP, Tsuruta D, Hashimoto T
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Journal Title
Exp Dermatol
Volume: 26(9)
Pages: 811-819
Related Report
Peer Reviewed / Open Access
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[Journal Article] Paraneoplastic pemphigus associated with Castleman disease: progression from mucous to mucocutaneous lesions with epitope-spreading phenomena2017
Author(s)
Okahashi K, Oiso N, Ishii N, Miyake M, Uchida S, Matsuda H, Kitano M, Hida J, Kawai S, Sano A, Hashimoto T, Kawada A
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Journal Title
Br J Dermatol
Volume: 176(5)
Pages: 1406-1409
Related Report
Peer Reviewed / Open Access
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[Journal Article] Non-paraneoplastic autoimmune subepidermal bullous disease associated with fatal bronchiolitis obliterans2017
Author(s)
Orime M, Tomiyama K, Hashidate H, Yoshida S, Hokari S, Tsuda A, Yokoyama H, Narita JI, Uchida Y, Kanekura T, Abe R, Ishii N, Hashimoto T, Kawai K
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Journal Title
J Dermatol
Volume: 44(4)
Pages: 461-464
Related Report
Peer Reviewed / Open Access
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[Journal Article] A case of IgA pemphigus foliaceus with high scores on drug-induced lymphocyte stimulation tests secondary to various drugs2017
Author(s)
Saito-Shono T, Nakamura Y, Sakai T, Ishikawa K, Goto M, Takeo N, Hatano Y, Seguchi S, Ishii N, Koga H, Hashimoto T, Fujiwara S
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Journal Title
Eur J Dermatol
Volume: 27(6)
Pages: 664-665
Related Report
Peer Reviewed / Open Access
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[Journal Article] Serological diagnostics in the detection of IgG autoantibodies against human collagen VII in epidermolysis bullosa acquisita: a multicentre analysis2017
Author(s)
Schmidt T, Hoch M, Lotfi Jad SS, Solimani F, Di Zenzo G, Marzano AV, Goebeler M, Cozzani E, Kern JS, Sitaru C, Lakos Jukic I, Sardy M, Uzun S, Jedlickova H, Glaser R, Kaneda M, Eming R, Gopel G, Ishii N, Greene B, Hashimoto T, Hertl M
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Journal Title
Br J Dermatol
Volume: 177(6)
Pages: 1683-1692
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Anti-early endosome antigen 1 autoantibodies were detected in a pemphigus-like patient but not in the majority of pemphigus diseases.2016
Author(s)
Nishikawa R, Takahashi H, Matsuda M, Imaoka K, Ogawa M, Teye K, Tsuchisaka A, Koga H, Komorowski L, Probst C, Hachiya T, Fritzler MJ, Ishii N, Ohata C, Furumura M, Krol RP, Muro Y, Morita E, Hashimoto T
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Journal Title
Exp Dermatol
Volume: 25
Issue: 5
Pages: 369-371
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Clinical and immunological profiles of anti-BP230-type bullous pemphigoid: Restriction of epitopes to the C-terminal domain of BP230, shown by novel ELISAs of BP230-domain specific recombinant proteins.2016
Author(s)
Hayakawa T, Teye K, Hachiya T, Uehara R, Hashiguchi M, Kawakami T, Li X, Tsuchisaka A, Ohara K, Sogame R, Koga H, Hamada T, Ohata C, Furumura M, Ishii N, Fukano H, Shimozato K, Hashimoto T
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Journal Title
Eur J Dermatol
Volume: 26
Issue: 2
Pages: 155-163
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Integrin β4 is a major target antigen in pure ocular mucous membrane pemphigoid.2016
Author(s)
Li X, Qian H, Sogame R, Hirako Y, Tsuruta D, Ishii N, Koga H, Tsuchisaka A, Jin Z, Tsubota K, Fukumoto A, Sotozono C, Kinoshita S, Hashimoto T
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Journal Title
Eur J Dermatol
Volume: 26(3)
Issue: 3
Pages: 247-253
DOI
Related Report
Peer Reviewed
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[Journal Article] Granular C3 Dermatosis.2016
Author(s)
Hashimoto T, Tsuruta D, Yasukochi A, Imanishi H, Sekine H, Fujita T, Wanibuchi H, Gi M, Kárpáti S, Sitaru C, Zone JJ, Endo D, Abe S, Nishino T, Koji T, Ishii N.
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Journal Title
Acta Derm Venereol
Volume: 00
Pages: 00-00
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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