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Analysis of heterogeneity for the pathomechamisms of chronic prurigo and itch

Research Project

Project/Area Number 16K10181
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dermatology
Research InstitutionNational Defense Medical College

Principal Investigator

SATOH TAKAHIRO  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 皮膚科学, 教授 (30235361)

Research Collaborator HASHIMOTO Takashi  東京医科歯科大学, 大学院医歯学総合研究科・皮膚科学分野, 助教
Satoh YASUSHI  防衛医科大学校, 医学教育部医学科専門課程・薬理学講座, 准教授
Nishizawa AYA  防衛医科大学校病院, 皮膚科, 講師
Munetsugu TAKICHI  防衛医科大学校, 医学教育部医学科専門課程, 助教
Ishikawa TAKAHIRO  防衛医科大学校, 医学教育部医学科専門課程, 助教
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords痒疹 / 痒み / アロネーシス / ERK2 / ERK / 接触過敏反応 / 好塩基球 / 皮膚アレルギー
Outline of Final Research Achievements

Chronic prurigo is a common but treatment-resistant skin disease of unknown etiology. Patients with prurigo nodularis, prugio chronica multiformis, and prurig subacuta showed high blood levels of prurigogens, such as β-endorphin and autotaxin. These mediators were also highly expressed in epidermal keratinocytes from prurigo patients, in particular, prurigo chronica multiformis. In addition, experiments with mice deficient in ERK2 of central nervous systems indicated that ERK2 contributes to acute and chronic pruritus in chronic skin inflammation.

Academic Significance and Societal Importance of the Research Achievements

痒みは極めて一般的な症状でありながら、その病態はいまだ謎が多い。通常痒み止めとして用いられる抗ヒスタミン薬は蕁麻疹を除くと、必ずしも十分な効果がえられない。とくに痒疹は治療抵抗性でありその頑固な痒みから患者の苦痛は大きい。本研究で、βエンドルフィン、オートタキシン、神経ERKといったあらたな痒み治療の標的を見出すことができ、今後治療への応用が期待できる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (33 results)

All 2018 2017 2016

All Journal Article (16 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 16 results,  Open Access: 6 results,  Acknowledgement Compliant: 1 results) Presentation (9 results) (of which Int'l Joint Research: 9 results) Book (8 results)

  • [Journal Article] Repeated Amblyomma testudinarium tock bites are associated with elevated anti-galactose-α-a,3-galactose carbohydrate IgE antibody levels: A retrospective cohort study in a single institute.2018

    • Author(s)
      Hashizume H, Fujiyama T, Umayahara T, Kageyama R, Walls AF, Satoh T.
    • Journal Title

      J Am Acad Dermatol

      Volume: 78 Issue: 6 Pages: 1135-1141

    • DOI

      10.1016/j.jaad.2017.12.028

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Acroangiodermatitis with pincer nail of the finger due to venous hypertension from hemodialysis arteriovenous shunt.2018

    • Author(s)
      Ishikawa T, Nishizawa A, Satoh T.
    • Journal Title

      Eur J Dermatol

      Volume: 128 Issue: 2 Pages: 247-248

    • DOI

      10.1684/ejd.2018.3226

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Toe Gangrene Associated with Macroangiopathy in Systemic Sclerosis: A Case Series on the Unreliability of the Ankle-brachial Pressure Index.2018

    • Author(s)
      Hashimoto T, Satoh T, Yokozeki H.
    • Journal Title

      Acta Derm Venereol.

      Volume: 98(5) Issue: 5 Pages: 532-533

    • DOI

      10.2340/00015555-2897

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Acute generalized exanthematous pustulosis associated with Helicobacter pylori eradication therapy with elevated serum procalcitonin.2018

    • Author(s)
      Yamazaki Y, Watanabe R, Ishikawa R, Munetsugu T, Nishizawa A, Satoh T.
    • Journal Title

      Eur J Dermatol

      Volume: 28 Issue: 2 Pages: 259-260

    • DOI

      10.1684/ejd.2018.3236

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Wells’ syndrome associated with Coxackievirus A6 infection.2018

    • Author(s)
      Yoshii Y, Ishikawa T, Munetsugu T, Nishizawa A, Fujimoto N, Satoh T.
    • Journal Title

      Acta Derm Venereol

      Volume: 98 Issue: 8 Pages: 791-792

    • DOI

      10.2340/00015555-2985

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Papulonodular mucinosis with interstitial granulomatous-like histological changes in a male patient with systemic lupus erythematosus.2017

    • Author(s)
      Hashimoto T, Satoh T.
    • Journal Title

      J Dermatol

      Volume: 44 Issue: 3 Pages: 349-350

    • DOI

      10.1111/1346-8138.13524

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Influenza vaccine-induced acute generalized exanthematous pustulosis during pregnancy.2017

    • Author(s)
      Matsuo S, Nishizawa A, Oshio-Yoshii A, Satoh T.
    • Journal Title

      J Dermatol

      Volume: 44 Issue: 5 Pages: 598-599

    • DOI

      10.1111/1346-8138.13487

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Long-term, widespread infection of molluscum contagiosum with atopic dermatitis-like skin manifestations.2017

    • Author(s)
      Chikazawa S, Takai S, Furuya A, Kato T, Ohara O, Hashimoto T, Nonoyama S, Satoh T.
    • Journal Title

      Acta Derm Venereol

      Volume: 97 Issue: 2 Pages: 291-292

    • DOI

      10.2340/00015555-2511

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evaluation of the Correlation between Severity of Acquired Idiopathic Generalized Anhidrosis and Quality of Life Scores.2017

    • Author(s)
      Munetsugu T, Fujimoto T, Satoh T, Nakazato Y, Ohshima Y, Asahina M, Yokozeki H.
    • Journal Title

      J Dermatol

      Volume: 44 Issue: 7 Pages: 7470752-7470752

    • DOI

      10.1111/1346-8138.13785

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Fingernail involvement in adult Langerhans cell histiocytosis2017

    • Author(s)
      Ishikawa T, Nishizawa A, Satoh T.
    • Journal Title

      Eur J Dermatol

      Volume: 27 Issue: 3 Pages: 310-311

    • DOI

      10.1684/ejd.2017.2982

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Basophils and mast cells are crucial for reactions due to epicutaneous sensitization to ovalbumin.2017

    • Author(s)
      Yu R, Igawa K, Handa Y, Munetsugu T, Satoh T, Yokozeki H.
    • Journal Title

      Exp Dermatol.

      Volume: 26(9) Issue: 9 Pages: 778-784

    • DOI

      10.1111/exd.13279

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Mogamulizumab-induced toxicoderma-like eruptions and autoimmune hepatitis successfully treated with azathioprine in adult T-cell leukaemia/lymphoma.2017

    • Author(s)
      Nishizawa A, Ishikawa T, Hirose M, Satoh H, Nishii S, Tomita K, Hokari R, Satoh T.
    • Journal Title

      Eur J Dermatol

      Volume: 27 Issue: 6 Pages: 651-652

    • DOI

      10.1684/ejd.2017.3103

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Disseminated cutaneous nocardiosis with ocular involvement.2017

    • Author(s)
      Nishizawa A, Hirose M, Nagata Y, Takeuchi M, Satoh T.
    • Journal Title

      J Eur Acad Dermatol Venereol.

      Volume: 31 Issue: 11 Pages: 488-489

    • DOI

      10.1111/jdv.14328

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fish collagen is an important panallergen in the Japanese population2016

    • Author(s)
      Kobayashi Y, Akiyama H, Huge J, Kubota H, Chikazawa S, Satoh T, Miyake T, Uhara H, Okuyama R, Nakagawara R, Aihara M, Hamada-Sato N
    • Journal Title

      Allergy

      Volume: 未定 Issue: 5 Pages: 720-723

    • DOI

      10.1111/all.12836

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Accumulation of C-eractive protein in basal keratinocytes of normal skin2016

    • Author(s)
      Ono K, Fujimoto N, Akiyama M, Satoh T, Tajima S
    • Journal Title

      J Dermatol Sci

      Volume: 83 Issue: 1 Pages: 26-33

    • DOI

      10.1016/j.jdermsci.2016.04.002

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Effects of URAT1/SLC22A12 Nonfunctional Variants, R90H and W258X, on Serum Uric Acid Levels and Gout/hyperuricemia Progression2016

    • Author(s)
      Sakiyama M, Matsuo H, Shimizu S et al.
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 20148-20148

    • DOI

      10.1038/srep20148

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Pruritus in ordinary scabies: Its immunological responses and IL-31 from macrophages under overexpression of TSLP and periostin.2018

    • Author(s)
      1.Hashimoto T, satoh T, Yokozeki H.
    • Organizer
      International Investigative Dermatology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Repeated tick bites impact basophil kinetics and production of specific IgE antibody to galactose-α-1,3-galactose carbohydrate.2018

    • Author(s)
      2.Kageyama R, kaneko Y, Fujiyama T, satoh T, Hashizume H.
    • Organizer
      27th European Academy of Dermatology and Venereology Congrress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Basophils release amphiregulin and may contribute to murine models of prurigo reaction and MC903-induced atopic dermatitis-like skin inflammation.2017

    • Author(s)
      Hashimoto T, Satoh T, Yokozeki H.
    • Organizer
      76th Annual Meeting of the Society for Investigative Dermatoogy
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Reciprocal functions of ERK2 in peripheral and central nervous systems for itch responses.2017

    • Author(s)
      Matsuo S, Hashimoto T, Furuya A, Itakura S, Endo S, Satoh Y, Satoh T.
    • Organizer
      The 42nd Annual Meeting of The Japanese Society for Investigative Dermatology,
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Common dysfunctional variants of ABCG2 may contribute to acquired photosensitivity by porphyrin accumulation.2017

    • Author(s)
      Sakiyama M, Matsuo H, Yonekura Y, Ishikawa T, Nakayama A, Higashino T, Fujimoto N, Satoh T, Shinomiya N.
    • Organizer
      The 42nd Annual Meeting of The Japanese Society for Investigative Dermatology,
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Basophils require interaction with CD49b (+)/c-kit (+) cells through L-selectin for the induction of IgE-mediated chronic allergic inflammation.2016

    • Author(s)
      Ishikawa T, Satoh T, Saeki K, Yokozeki H
    • Organizer
      The 41st Annual Meeting of The Japanese Society for Investigative Dermatology
    • Place of Presentation
      Sendai
    • Year and Date
      2016-12-09
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Pruritus in scabies infestation: implications of Th2 immunity and IL-31.2016

    • Author(s)
      Hashimoto T, Satoh T, Yokozeki H
    • Organizer
      The 12th Meeting of the German-Japanese Society of Dermatology, Post Congress in Tokyo
    • Place of Presentation
      Karuizawa
    • Year and Date
      2016-09-15
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Generalized pruritus in primary sclerosing cholangitis: implications of histamine release by lysophosphatidic acid2016

    • Author(s)
      Hashimoto T, Satoh T, Yokozeki H
    • Organizer
      The 12th Meeting of the German-Japanese Society of Dermatology
    • Place of Presentation
      Karuizawa
    • Year and Date
      2016-09-13
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Implication of amphiregulin in basophil-dependent prurigo-like skin reactions2016

    • Author(s)
      Hashimoto T, Satoh T, Yokozeki H
    • Organizer
      The 46th Annual Meeting for the European Society for Dermatological Research.
    • Place of Presentation
      Munich
    • Year and Date
      2016-09-08
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Book] 今日の治療指針―私はこうしているー20172018

    • Author(s)
      佐藤貴浩
    • Total Pages
      1
    • Publisher
      医学書院
    • Related Report
      2018 Annual Research Report
  • [Book] 帯状疱疹を発症。抗ウイルス薬の選択、投与法およびその後の神経痛に対する対応は? CKD患者の薬物治療2018

    • Author(s)
      佐藤貴浩
    • Total Pages
      3
    • Publisher
      文光堂
    • Related Report
      2018 Annual Research Report
  • [Book] 今さらですが、「痒疹」とは? What’s new in 皮膚科学 2018-20192018

    • Author(s)
      佐藤貴浩
    • Total Pages
      2
    • Publisher
      メディカルレビュー社
    • Related Report
      2018 Annual Research Report
  • [Book] 今日の治療指針:皮膚そう痒症2017

    • Author(s)
      佐藤貴浩
    • Total Pages
      1
    • Publisher
      医学書院
    • Related Report
      2017 Research-status Report
  • [Book] 私の治療201602017 接触皮膚炎2017

    • Author(s)
      佐藤貴浩
    • Total Pages
      1
    • Publisher
      日本医事新報社
    • Related Report
      2017 Research-status Report
  • [Book] 透析患者やの薬剤の考え方:透析患者の痒みの現状と薬の使い方について教えてください2017

    • Author(s)
      佐藤貴浩
    • Total Pages
      4
    • Publisher
      中外医学社
    • Related Report
      2017 Research-status Report
  • [Book] 皮膚科研修医ノート 3痒疹2016

    • Author(s)
      佐藤貴浩
    • Total Pages
      3
    • Publisher
      診断と治療社
    • Related Report
      2016 Research-status Report
  • [Book] 透析患者診療に役立つ診断と重症度判定 かゆみ2016

    • Author(s)
      佐藤貴浩
    • Total Pages
      2
    • Publisher
      日本メディカルセンター
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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