Identification of glycoproteins as markers of depression
| Project/Area Number |
16K10189
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Yamaguchi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
松尾 幸治 埼玉医科大学, 医学部, 教授 (00292912)
内田 周作 山口大学, 医学部附属病院, 講師 (10403669)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | うつ病 / 糖鎖 / バイオマーカー / Glycosylation / Depression |
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| Outline of Final Research Achievements |
Glycosylation, the addition of a carbohydrate moiety to a protein during biosynthesis, is a common post-translational modification involved in several disease states. Specific protein-glycan structures have been reported to be useful as biomarkers for cancer and some neuropsychiatric disorders; however, the relationship between glycosylation of plasma proteins and major depressive disorder (MDD) has not been studied. This study aimed to determine whether the plasma protein-glycan structure would differ in MDD from typical values, using both a stress-based mouse model and samples from patients with MDD. The glycan structure profile of plasma proteins might represent candidate biomarkers for MDD.
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| Academic Significance and Societal Importance of the Research Achievements |
うつ病患者の血漿タンパク質の糖鎖について調べ、うつ病患者で変化する糖鎖変化を見つけることが出来た。また、うつ病モデルマウスの血漿タンパク質でも、ストレス負荷を受けたマウスで変化している糖鎖変化を同定できた。今後、さらに詳しく血漿の糖鎖を調べることで、うつ病の診断につながるような検査方法が見つかる可能性がある。また、うつ病モデルマウスの脳内タンパク質の糖鎖を調べることで、うつ病の病態を引き起こす原因となるような糖鎖変化が見つかるかもしれない。
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] CRTC1 Nuclear Translocation Following Learning Modulates Memory Strength via Exchange of Chromatin Remodeling Complexes on the Fgf1 Gene.2017
Author(s)
Uchida S, Teubner BJ, Hevi C, Hara K, Kobayashi A, Dave RM, Shintaku T, Jaikhan P, Yamagata H, Suzuki T, Watanabe Y, Zakharenko SS, Shumyatsky GP.
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Journal Title
Cell Rep
Volume: 18
Issue: 2
Pages: 352-366
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Hippocampal MicroRNA-124 Enhances Chronic Stress Resilience in Mice.2016
Author(s)
Higuchi F, Uchida S, Yamagata H, Abe-Higuchi N, Hobara T, Hara K, Kobayashi A, Shintaku T, Itoh Y, Suzuki T, Watanabe Y.
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Journal Title
J Neurosci.
Volume: 36
Issue: 27
Pages: 7253-7267
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Disrupted orbitomedial prefrontal limbic network in individuals with later-life depression2016
Author(s)
Harada K, Matsuo K, Nakashima M, Hobara T, Higuchi N, Higuchi F, Nakano M, Otsuki K, Shibata T, Watanuki T, Matsubara T, Fujita Y, Shimoji K, Yamagata H, Watanabe Y
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Journal Title
Journal of Affective Disorders
Volume: 204
Pages: 112-119
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Identification of biomarkers in blood in geriatric patients with early-onset major depressive disorder2016
Author(s)
YAMAGATA H, UCHIDA S, HARADA K, HIGUCHI F, MATSUO K, MIYATA S, FUKUDA M, MIKUNI M, WATANABE Y
Organizer
Neuroscience 2016, SfN's 46th annual meeting
Place of Presentation
San Diego Convention Center, USA
Related Report
Int'l Joint Research
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[Presentation] うつ病と神経細胞死2016
Author(s)
山形弘隆、内田周作、樋口文宏、渡邉義文
Organizer
第38回日本生物学的精神医学会
Place of Presentation
福岡コンベンションセンター（福岡県・福岡市）
Related Report
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