| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Schizophrenia is one of major psychiatric disorders with lifetime prevalence about 1%. Multimodal studies have been done and the developmental hypothesis or synaptic hypothesis is suggested, but the pathophysiology is still unclear because of the inaccessibility to living brain cells. Thus we tried to investigate the cellular phenotype of iPSC-derived neurons from schizophrenia patient focusing on complement and complement regulatory factors. As a result, gene expression of synaptic protein and complement regulatory factor CSMD-1 was different between groups.
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