Association of the 40 candidate gene variants with Cognitive Function in Japanese Subjects
Project/Area Number |
16K10192
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Psychiatric science
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Research Institution | Dokkyo Medical University |
Principal Investigator |
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Project Period (FY) |
2016-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | 統合失調症 / 双極性障害 / 認知機能 / BACS / 一塩基多型 / BACS-J / 中間表現型 / genetic risk score |
Outline of Final Research Achievements |
We selected from literatures and genotyped 40 single nucleotide polymorphisms (SNPs) using MassARRAY. Associations between each SNP and individual z-scores of the BACS cognitive domains were analyzed using a linear regression that was implemented in PLINK 1.07. P values were determined by running 10,000 permutations using the max (T) procedure adjusted for multiple tests. The significance levels were set at 0.00833 (0.05/6) to correct for the six BACS subdomains and at 0.05 for composite scores. For controls,rs13000464 (GLS1) was significantly associated with BACS composite scores. For patients with bipolar disorder, rs16887244 (LSM1) was significantly associated with BACS composite scores. Conclusions: These results warrant further study on association between cognition and genetic variants.
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Academic Significance and Societal Importance of the Research Achievements |
本来ならばより多数のSNPを解析することが望ましかったが、予算の関係上、先行研究で何らかの認知機能あるいは機能的脳画像所見で関連が報告された40個の一塩基多型(SNP)と認知機能との相関を健常対照者、統合失調症患者、双極性障害患者別に検討した。当初は統合失調症の患者の認知機能の障害と関連するSNPが見いだされる予想を立てていたが、逆に健常対照者、双極性障害患者の認知機能の成績と関連するSNPが見いだされた。本研究の統合失調症患者群のBACSの認知機能は健常対照者のものに比べ大きく下回っており、この成績に及ぼす当該SNP以外の不明な要因の効果量が優位であったかもしれない。考察して発表していく。
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Association of polygenic score for Schizophrenia and HLA and inflammation genes with response to lithium in Bipolar Affective Disorder. A genome-wide association study2018
Author(s)
Amare AT, Schubert KO, Hou L, Clark SR, Papiol S, Heilbronner U, Degenhardt F, Tekola-Ayele F, Hsu Y-H, Shekhtman T, Adli M, Akula N, Akiyama K et al (全112名中Akiyama K 13番目)
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Journal Title
JAMA Psychiatry
Volume: 75
Pages: 65-74
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Cognitive function, treatment response to lithium, and social functioning in Japanese patients with bipolar disorder.2017
Author(s)
Saito S, Fujii K, Ozeki Y, Ohmori K, Honda G, Mori H, Kato K, Kuroda J, Aoki A, Asahi H, Sato H, Shimoda K, Akiyama K.
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Journal Title
Bipolar Disorders
Volume: 19
Issue: 7
Pages: 552-562
DOI
Related Report
Peer Reviewed
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[Journal Article] Multi-regression analysis revealed a relationship between L-serine and methionine, in the component of one-carbon metabolism , in the normal control but not in the schizphrenia2016
Author(s)
Takano Y, Ozeki Y, Sekine M, Fujii K, Watanabe T, Okayasu H, Shinozaki T, Aoki A, Akiyama K, Homma H, Shimoda K
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Journal Title
Annals of General Psychiatry
Volume: 15
Issue: 1
Pages: 23-23
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Plasma concentrations of three methylated arginines,endogenous nitric oxide synthase inhibitors, in schizophrenic patients undergoing antipsychotic drug treatment2016
Author(s)
Satoko Nonaka-Hashida, Masae Sekine, Yuji Ozeki , Kumiko Fujii, Kazufumi Akiyama, Kazutaka Shimoda, Makoto Tsunoda, Masumi Katane, Yasuaki Saitoh, Tetsuya Miyamoto, Hiroshi Homma
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Journal Title
Psychiatry Research
Volume: 238
Pages: 203-210
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Phosphoserine phosphatase activity is elevated and correlates negatively with plasma d-serine concentration in patients with schizophrenia.2016
Author(s)
Yuji Ozeki, Masae Sekine, Kumiko Fujii, Takashi Watanabe, Hiroaki Okayasu, Yumiko Takano, Takahiro Shinozaki, Akiko Aoki, Kazufumi Akiyama, Hiroshi Homma, Kazutaka Shimoda
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Journal Title
Psychiatry Research
Volume: 237
Pages: 344-350
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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