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Genetic prediction of depression in the employees or in the general population

Research Project

Project/Area Number 16K10193
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionTeikyo Heisei University

Principal Investigator

OTOWA Takeshi  帝京平成大学, 臨床心理学研究科, 教授 (70456119)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords遺伝子 / うつ状態 / ストレス / 環境 / 産業 / 予測因子 / 全ゲノム関連解析
Outline of Final Research Achievements

The aims of the present study are 1) to predict depression using combination of risk genes and 2) to identify candidate genes that influence the association of work stress with depression. Therefore, we performed a genome-wide gene by environment (G × E) interaction analysis in Japanese employees living in Kyushu (n=400) and Hokuriku (n=300) regions. The genetic predictions of depression using two independent samples were non-significant. However, we found several candidate genes of depression analyzing gene by environment (G × E) interaction.

Academic Significance and Societal Importance of the Research Achievements

職場では2015年12月から義務化されたストレスチェック制度導入や、今後は働き方改革などの制度によって長時間残業などの職場ストレスの低減が図られようとしている。本研究では、職場関連ストレスによってうつ状態につながる個人差の背景には遺伝的要因による可能性があることを示唆し、候補となりうる遺伝的座位を示した。こうした研究によってハイリスクの個人については早めの疾病教育や産業保健スタッフによるフォローを行うなどの対策が取りやすくなると考えられる。本研究は以上の点から今後のうつ病の予防や介入に意義があるものと考えられた。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (9 results)

All 2019 2018

All Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (3 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Shared genetic etiology between anxiety disorders and psychiatric and related intermediate phenotypes.2019

    • Author(s)
      Ohi K, Otowa T, Shimada M, Sasaki T, Tanii H.
    • Journal Title

      Psychological Medicine

      Volume: - Issue: 4 Pages: 692-704

    • DOI

      10.1017/s003329171900059x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DSMにおける不安症(不安障害)の変遷と疫学2019

    • Author(s)
      音羽 健司
    • Journal Title

      老年精神医学雑誌

      Volume: 30 Pages: 358-365

    • Related Report
      2018 Annual Research Report
  • [Journal Article] A variant at 9q34.11 is associated with HLA-DQB1*06:02 negative essential hypersomnia2018

    • Author(s)
      Miyagawa T, Khor SS, Toyoda H, Kanbayashi T, Imanishi A, Sagawa Y, Kotorii N, Kotorii T, Ariyoshi Y, Hashizume Y, Ogi K, Hiejima H, Kamei Y, Hida A, et al.
    • Journal Title

      J Hum Genet

      Volume: 63 Issue: 12 Pages: 1259-1267

    • DOI

      10.1038/s10038-018-0518-8

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Whole-exome sequencing and gene-based rare variant association tests suggest that PLA2G4E might be a risk gene for panic disorder. Transl Psychiatry.2018

    • Author(s)
      Morimoto Y, Shimada-Sugimoto M, Otowa T, Yoshida S, Kinoshita A, Mishima H, Yamaguchi N, Mori T, Imamura A, Ozawa H, Kurotaki N, Ziegler C, Domschke K, Deckert J, Umekage T, Tochigi M, Kaiya H, Okazaki Y, Tokunaga K, Sasaki T, Yoshiura KI, Ono S.
    • Journal Title

      Transl Psychiatry

      Volume: 8 Issue: 1 Pages: 41-41

    • DOI

      10.1038/s41398-017-0088-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 遺伝子解析からみた不安症と双極性障害、自閉スペクトラム症2018

    • Author(s)
      音羽 健司
    • Journal Title

      精神科

      Volume: 33 Pages: 425-430

    • Related Report
      2018 Annual Research Report
  • [Journal Article] An epigenome-wide methylation study of healthy individuals with or without depressive symptoms.2018

    • Author(s)
      Shimada M, Otowa T, Miyagawa T, Umekage T, Kawamura Y, Bundo M, Iwamoto K, Ikegame T, Tochigi M, Kasai K, Kaiya H, Tanii H, Okazaki Y, Tokunaga K, Sasaki T. An epigenome-wide methylation study of healthy individuals with or without depressive symptoms.
    • Journal Title

      J Hum Genet

      Volume: 63 Issue: 3 Pages: 319-326

    • DOI

      10.1038/s10038-017-0382-y

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Genome-wide gene-environment study of depression in Japanese employees.2018

    • Author(s)
      Otowa T, Shimada M, Kawakami N, Tsutsumi A.
    • Organizer
      World Congress of Psychiatric Genetics
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Genome-wide gene-environment study of depression in Japanese employees.2018

    • Author(s)
      Otowa T, Shimada M, Kawakami N, Tsutsumi A.
    • Organizer
      Joint International Society for Clinical Biostatistics and Australian Statistical Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 最近のGWASからみた不安症と双極性障害2018

    • Author(s)
      音羽健司
    • Organizer
      日本不安症学会
    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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