Genetic prediction of depression in the employees or in the general population

• Project/Area Number: 16K10193
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Teikyo Heisei University
• Principal Investigator: OTOWA Takeshi 帝京平成大学, 臨床心理学研究科, 教授 (70456119)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 遺伝子 / うつ状態 / ストレス / 環境 / 産業 / 予測因子 / 全ゲノム関連解析

Outline of Final Research Achievements

The aims of the present study are 1) to predict depression using combination of risk genes and 2) to identify candidate genes that influence the association of work stress with depression. Therefore, we performed a genome-wide gene by environment (G × E) interaction analysis in Japanese employees living in Kyushu (n=400) and Hokuriku (n=300) regions. The genetic predictions of depression using two independent samples were non-significant. However, we found several candidate genes of depression analyzing gene by environment (G × E) interaction.

Academic Significance and Societal Importance of the Research Achievements

職場では2015年12月から義務化されたストレスチェック制度導入や、今後は働き方改革などの制度によって長時間残業などの職場ストレスの低減が図られようとしている。本研究では、職場関連ストレスによってうつ状態につながる個人差の背景には遺伝的要因による可能性があることを示唆し、候補となりうる遺伝的座位を示した。こうした研究によってハイリスクの個人については早めの疾病教育や産業保健スタッフによるフォローを行うなどの対策が取りやすくなると考えられる。本研究は以上の点から今後のうつ病の予防や介入に意義があるものと考えられた。

Research Products

• [Journal Article] Shared genetic etiology between anxiety disorders and psychiatric and related intermediate phenotypes. (2019)
  • Author(s): Ohi K, Otowa T, Shimada M, Sasaki T, Tanii H.
  • Journal Title: Psychological Medicine Volume: - Issue: 4 Pages: 692-704
  • DOI: 10.1017/s003329171900059x
  • Peer Reviewed
• [Journal Article] DSMにおける不安症（不安障害）の変遷と疫学 (2019)
  • Author(s): 音羽 健司
  • Journal Title: 老年精神医学雑誌 Volume: 30 Pages: 358-365
• [Journal Article] A variant at 9q34.11 is associated with HLA-DQB1*06:02 negative essential hypersomnia (2018)
  • Author(s): Miyagawa T, Khor SS, Toyoda H, Kanbayashi T, Imanishi A, Sagawa Y, Kotorii N, Kotorii T, Ariyoshi Y, Hashizume Y, Ogi K, Hiejima H, Kamei Y, Hida A, et al.
  • Journal Title: J Hum Genet Volume: 63 Issue: 12 Pages: 1259-1267
  • DOI: 10.1038/s10038-018-0518-8
  • Peer Reviewed / Open Access
• [Journal Article] Whole-exome sequencing and gene-based rare variant association tests suggest that PLA2G4E might be a risk gene for panic disorder. Transl Psychiatry. (2018)
  • Author(s): Morimoto Y, Shimada-Sugimoto M, Otowa T, Yoshida S, Kinoshita A, Mishima H, Yamaguchi N, Mori T, Imamura A, Ozawa H, Kurotaki N, Ziegler C, Domschke K, Deckert J, Umekage T, Tochigi M, Kaiya H, Okazaki Y, Tokunaga K, Sasaki T, Yoshiura KI, Ono S.
  • Journal Title: Transl Psychiatry Volume: 8 Issue: 1 Pages: 41-41
  • DOI: 10.1038/s41398-017-0088-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 遺伝子解析からみた不安症と双極性障害、自閉スペクトラム症 (2018)
  • Author(s): 音羽 健司
  • Journal Title: 精神科 Volume: 33 Pages: 425-430
• [Journal Article] An epigenome-wide methylation study of healthy individuals with or without depressive symptoms. (2018)
  • Author(s): Shimada M, Otowa T, Miyagawa T, Umekage T, Kawamura Y, Bundo M, Iwamoto K, Ikegame T, Tochigi M, Kasai K, Kaiya H, Tanii H, Okazaki Y, Tokunaga K, Sasaki T. An epigenome-wide methylation study of healthy individuals with or without depressive symptoms.
  • Journal Title: J Hum Genet Volume: 63 Issue: 3 Pages: 319-326
  • DOI: 10.1038/s10038-017-0382-y
  • Peer Reviewed / Open Access
• [Presentation] Genome-wide gene-environment study of depression in Japanese employees. (2018)
  • Author(s): Otowa T, Shimada M, Kawakami N, Tsutsumi A.
  • Organizer: World Congress of Psychiatric Genetics
  • Int'l Joint Research
• [Presentation] Genome-wide gene-environment study of depression in Japanese employees. (2018)
  • Author(s): Otowa T, Shimada M, Kawakami N, Tsutsumi A.
  • Organizer: Joint International Society for Clinical Biostatistics and Australian Statistical Conference
  • Int'l Joint Research
• [Presentation] 最近のGWASからみた不安症と双極性障害 (2018)
  • Author(s): 音羽健司
  • Organizer: 日本不安症学会