• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

What exists between schizophrenia and bipolar disorder ~genomic analysis by whole-genome resequence~

Research Project

Project/Area Number 16K10196
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionOsaka Medical College

Principal Investigator

Kanazawa Tetsufumi  大阪医科大学, 医学部, 教授 (20534100)

Co-Investigator(Kenkyū-buntansha) 橋口 康之  大阪医科大学, 医学部, 講師 (70436517)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2017: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2016: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Keywords非定型精神病 / 次世代シーケンサー / 全ゲノムシーケンス / 多発家系 / 統合失調症 / 双極性障害 / 遺伝子研究 / DCC / 急性一過性精神病 / MHC領域 / 自己免疫疾患 / 全身性エリテマトーデス / DCC遺伝子 / 遺伝研究 / 精神病 / SLE / 全ゲノム解析 / 精神医学 / 遺伝学
Outline of Final Research Achievements

Atypical psychosis (similar to acute and transient psychotic disorder) is highly heritable, but the causal genes remain unidentified. We conducted whole-genome sequencing on multiplex Japanese families with atypical psychosis. In addition to the next-generation analysis, HLA typing has been conveyed to check the similarity with autoimmune disease, such as systemic lupus erythematosus (SLE). Shared causal polymorphisms in the Deleted in Colorectal Carcinoma, Netrin 1 receptor (DCC) gene were found in one multiplex family with three patients, and One Cut Homeobox 2 (ONECUT2) genes were found to be shared in seven patients. Next-generation sequencing analysis of the MHC region (previously suggested to be a hot region in atypical psychosis) using HLA typing (HLA-DRB1) revealed a common vulnerability with SLE (systemic lupus erythematosus) among five patients. Focusing on a specific clinical phenotype is key for elucidating the genetic factors that underlie the complex traits of psychosis.

Academic Significance and Societal Importance of the Research Achievements

これまで明らかにされていなかった非定型精神病、すなわち急性に精神病症状を呈し、周期的に再発を繰り返す患者の遺伝学的特徴を世界で初めて捕捉することができた。これは詳細な遺伝子調査が可能な次世代シーケンサーによってでしか成し遂げられない成果で、さらに自己免疫疾患であるSLEとの遺伝的な近しさを明らかにしえたことで、これまで謎であった両者の症状における近似性の秘密を遺伝学を用いて白日の下に晒したといえる。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (13 results)

All 2018 2017

All Journal Article (9 results) (of which Peer Reviewed: 8 results,  Open Access: 4 results) Presentation (4 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results)

  • [Journal Article] わが国における非定型精神病の経時的実態調査2018

    • Author(s)
      金沢 徹文, 加藤 悦史, 川村 諭, 山田 浩樹, 康 純, 針間 博彦, 阿部 隆明, 坂元 薫, 渡辺 憲, 中山 和彦, 兼本 浩祐, 岩波 明, 米田 博, 須賀 英道
    • Journal Title

      精神科治療学

      Volume: 33 Pages: 893-897

    • NAID

      40021641342

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 統合失調症と双極性障害の遺伝子2018

    • Author(s)
      町田 康博, 金沢 徹文
    • Journal Title

      精神科

      Volume: 32 Pages: 243-246

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Next-generation sequencing analysis of multiplex families with atypical psychosis.2018

    • Author(s)
      Okayama T, Hashiguchi Y, Kikuyama H, Yoneda H, Kanazawa T.
    • Journal Title

      Translational Psychiatry

      Volume: Oct 15;8(1):221 Issue: 1

    • DOI

      10.1038/s41398-018-0272-x

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] What can predict and prevent the long-term use of benzodiazepines?2018

    • Author(s)
      Hata Takeo、Kanazawa Tetsufumi、Hamada Takeshi、Nishihara Masami、Bush Ashley Ian、Yoneda Hiroshi、Nakajima Miki、Katsumata Takahiro
    • Journal Title

      Journal of Psychiatric Research

      Volume: 97 Pages: 94-100

    • DOI

      10.1016/j.jpsychires.2017.11.012

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparative Analysis of the WISC between Two ADHD Subgroups2018

    • Author(s)
      Kubo Yoichiro、Kanazawa Tetsufumi、Kawabata Yasuo、Tanaka Koyuki、Okayama Tatsushi、Fujta Miho、Tsutsumi Atsushi、Yokota Shingo、Yoneda Hiroshi
    • Journal Title

      Psychiatry Investigation

      Volume: 15 Issue: 2 Pages: 172-177

    • DOI

      10.30773/pi.2017.07.12

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 総説 単一精神病論2017

    • Author(s)
      菊山 裕貴、金沢 徹文、樽谷 精一郎、岡山 達志、米田 博
    • Journal Title

      BRAIN and NERVE

      Volume: 69 Issue: 6 Pages: 657-664

    • DOI

      10.11477/mf.1416200797

    • ISSN
      1344-8129, 1881-6096
    • Year and Date
      2017-06-01
    • Related Report
      2017 Research-status Report
  • [Journal Article] Schizophrenia genetics in the genome-wide era: a review of Japanese studies2017

    • Author(s)
      Kanazawa Tetsufumi、Bousman Chad A.、Liu Chenxing、Everall Ian P.
    • Journal Title

      npj Schizophrenia

      Volume: 3 Issue: 1

    • DOI

      10.1038/s41537-017-0028-2

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Mechanism of Anti-Epileptogenesis by Levetiracetam Treatment is Similar to the Spontaneous Recovery of Idiopathic Generalized Epilepsy during Adolescence2017

    • Author(s)
      Kikuyama Hiroki、Hanaoka Tadahito、Kanazawa Tetsufumi、Yoshida Yasushi、Mizuno Takafumi、Toyoda Hirotaka、Yoneda Hiroshi
    • Journal Title

      Psychiatry Investigation

      Volume: 14 Issue: 6 Pages: 844-844

    • DOI

      10.4306/pi.2017.14.6.844

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 満田の非定型精神病に対する現代的解釈 非定型精神病2017

    • Author(s)
      岡山 達志, 菊山 裕貴, 金沢 徹文, 橋口 康之, 桂 良輔, 木下 真也, 米田 博
    • Journal Title

      精神神経学雑誌

      Volume: 119 Pages: 565-572

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] Next-Generation Sequencing Analysis of Multiplex Families With Atypical Psychosis (Acute and Transient Psychosis)2018

    • Author(s)
      Tetsufumi Kanazawa, Tatsushi Okayama, Yaysuyuki Hashiguchi, Hiroki Kikuyama, and Hiroshi Yoneda
    • Organizer
      World Congress of Psychiatric Genetics
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 非定型精神病多発家系の次世代シークエンサーを用いた遺伝子解析2018

    • Author(s)
      岡山 達志、金沢 徹文、菊山 裕貴、 橋口康之、康 純、米田 博
    • Organizer
      精神神経学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Beyond the Robust Genetic Architecture of Schizophrenia2018

    • Author(s)
      Tetsufumi Kanazawa
    • Organizer
      WFSBP Asia Pacific Regional Congress of Biological Psychiatry
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 非定型精神病の疫学2017

    • Author(s)
      金沢徹文
    • Organizer
      第113回日本精神神経学会
    • Related Report
      2017 Research-status Report
    • Invited

URL: 

Published: 2016-04-21   Modified: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi