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Effects of Omega-3 fatty acids for schizophrenia and at-risk mental state

Research Project

Project/Area Number 16K10205
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionUniversity of Toyama

Principal Investigator

Higuchi Yuko  富山大学, 附属病院, 講師 (60401840)

Co-Investigator(Kenkyū-buntansha) 瀬尾 友徳  富山大学, 附属病院, 助教 (00377300)
鈴木 道雄  富山大学, 大学院医学薬学研究部(医学), 教授 (40236013)
住吉 太幹  国立研究開発法人国立精神・神経医療研究センター, 精神保健研究所 児童・予防精神医学研究部, 部長 (80286062)
Research Collaborator Seo Tomonori  
Tateno Takahiro  
Nishiyama Shimako  
Mizukami Yuko  
Ito Hiroko  
Kawasaki Yasuhiro  
Pasqual-Marqui Roberto  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords精神病発症予防 / 精神薬理学 / 認知神経科学 / 神経生理学 / 精神生理学 / 統合失調症 / 精神病発症リスク状態 / 不飽和脂肪酸 / 認知機能
Outline of Final Research Achievements

Subjects are patients with schizophrenia or at-risk mental state (ARMS). We divided them into omega-3 unsaturated fatty acid (PUFAs) administration group and non-administration group, and performed longitudinal measurement of electroencephalogram, cognitive function and so on.
As the result, in the administrated group, the improvements of negative symptom and general psychopathology measured by PANSS were found (p=0.003, p=0.01, respectively). The cognitive functions measured by brief assessment of cognition in schizophrenia (BACS) also improved [-0.32 ±0.85 → 0.16±0.85 (p=0.0005)]. Event related potential (P300) were analyzed by LORETA. Significant improvement in current source density was found mainly on frontal lobe (p=0.042), and it was suggested to be a mechanism of enhancement on cognitive functions and clinical symptoms.

Academic Significance and Societal Importance of the Research Achievements

統合失調症などの精神病は早期発見・支援が重要である。精神病発症リスク状態からの治療も検討されているが、確定診断に至らない患者には抗精神病薬による治療は推奨されていない。また標準的な治療を行っても症状が残遺する統合失調症患者は多くいる。今回、統合失調症およびARMSにω3不飽和脂肪酸を用いて介入研究を行ったところ投与前後で症状や認知機能の改善が認められ、生物学的にも脳波所見として前頭葉機能の改善が得られることが見出された。未だ予備的な検討ではあるものの、ARMSを含む精神病状態の患者に対する新たな介入の可能性となり得る方法が見出されたことは患者の社会的予後を改善することに繋がり、意義深い。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (9 results)

All 2019 2018 2017 2016 Other

All Int'l Joint Research (1 results) Presentation (8 results) (of which Int'l Joint Research: 3 results,  Invited: 6 results)

  • [Int'l Joint Research] Chonnam National University(韓国)

    • Related Report
      2018 Annual Research Report
  • [Presentation] Electrophysiological and neurocognitive indices in early psychosis and clinical high-risk patients2019

    • Author(s)
      Higuchi Y, Sumiyoshi T, Nishiyama S, Tateno T, Itoh H, Takahashi T, Suzuki M.
    • Organizer
      6th Asian Congress of Schizophrenia Research
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Electrophysiological and neurocognitive indices in schizophrenia and clinical high-risk patients. Symposium ”Psychotic disorder”2018

    • Author(s)
      Higuchi Y, Sumiyoshi T, Nishiyama S, Tateno T, Itoh H, Takahashi T, Suzuki M.
    • Organizer
      4th CNUH International Symposium of Psychiatry - Recent updates on major psychiatric diseases -
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 統合失調症肥料における事象関連電位の応用.シンポジウム「臨床神経生理学が精神疾患の治療において果たす役割-update-」.2018

    • Author(s)
      樋口悠子,住吉太幹,西山志満子,立野貴大,川﨑康弘,鈴木道雄.
    • Organizer
      第48回日本臨床神経生理学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 統合失調症および精神病発症リスク状態に対するω-3不飽和脂肪酸の効果:臨床的に良好な転帰が得られた2症例2017

    • Author(s)
      樋口 悠子
    • Organizer
      第12回日本統合失調症学会
    • Place of Presentation
      米子
    • Year and Date
      2017-03-25
    • Related Report
      2016 Research-status Report
  • [Presentation] 統合失調症および精神病発症リスク状態に対するomega-3不飽和脂肪酸の効果:臨床的に良好な転帰が得られた2症例.2017

    • Author(s)
      樋口悠子, 住吉太幹, 瀬尾友徳,伊藤博子, 西山志満子,小森祐子,鈴木道雄.
    • Organizer
      第12回日本統合失調症学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 統合失調症薬物療法における事象関連電位の応用.シンポジウム19「精神科薬物療法に応用が期待される生物学的指標」2017

    • Author(s)
      樋口悠子,住吉太幹,川﨑康弘,鈴木道雄.
    • Organizer
      第27回日本臨床神経精神薬理学会.
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 統合失調症の早期病態と治療2016

    • Author(s)
      鈴木 道雄
    • Organizer
      第20回日本精神保健・予防学会
    • Place of Presentation
      東京
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Neuroimaging and neurophysiological studies in early psychosis2016

    • Author(s)
      Michio Suzuki
    • Organizer
      Chonnam National University Hospital International Symposium
    • Place of Presentation
      Chonnam(Korea)
    • Year and Date
      2016-05-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited

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Published: 2016-04-21   Modified: 2020-03-30  

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