Association between Alzheimer's disease pathology and clinical symptoms/effect of shunt surgery in patients with idiopathic normal pressure hydrocephalus
Project/Area Number |
16K10212
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Psychiatric science
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Research Institution | Kochi University (2017-2018) Osaka University (2016) |
Principal Investigator |
KAZUI Hiroaki 高知大学, 教育研究部医療学系臨床医学部門, 教授 (30346217)
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Co-Investigator(Kenkyū-buntansha) |
貴島 晴彦 大阪大学, 医学系研究科, 教授 (10332743)
渡邉 嘉之 大阪大学, 医学系研究科, 特任教授(常勤) (20362733)
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Project Period (FY) |
2016-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 特発性正常圧水頭症 / アルツハイマー病 / アミロイド / PADRE / 歩行障害 / 記憶障害 / シャント術 / 脳血流 / 水頭症 / MRI / 髄液バイオマーカー / アミロイドPET / 臨床 / 老年精神医学 |
Outline of Final Research Achievements |
Recent studies revealed that Alzheimer disease (AD)-related pathology is highly prevalent in idiopathic normal pressure hydrocephalus (iNPH). We evaluated amyloid deposition in iNPH brain with PADRE images on a 3T MR scanner and clarified that iNPH patients with greater amyloid deposition in the precuneus showed worse gait disturbance. We also examined the association between AD pathology judged by amyloid beta 42 and total tau in CSF and improvement of clinical symptoms and cerebral blood flow (CBF) after lumbo-peritoneal shunt surgery (LPS). After LPS, all of the triad symptoms decreased in iNPH patients with and without AD pathology but memory improved only in iNPH patients without AD pathology. After LPS, a significant increase in regional CBF in the putamen, amygdala, hippocampus, and parahippocampal gyrus was observed in iNPH patients without AD pathology but no significant improvement in rCBF was observed in any region in iNPH patients with AD pathology.
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Academic Significance and Societal Importance of the Research Achievements |
本研究によって、わが国の多くの医療機関で実施可能な頭部MR画像でiNPH例の脳内アミロイド沈着を測定できる可能性が示唆された。またアミロイド沈着によってiNPHの臨床症状が重症化し、シャント術の効果が乏しくなる可能性も明らかにできた。これらの知見より、シャント術を実施するか否かを決定する際には、脳内アミロイド沈着の有無に関する情報も、患者及び家族には提供すべきであると考えられた。すなわち、iNPH診療ガイドラインに付け加えるべき重要な知見が本研究によって得られたと考えられた。
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Report
(4 results)
Research Products
(85 results)
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[Journal Article] Changes in brain morphology in patients in the preclinical stage of idiopathic normal pressure hydrocephalus.2019
Author(s)
Suehiro T, Kazui H, Kanemoto H, Yoshiyama K, Sato S, Suzuki Y, Azuma S, Matsumoto T, Kishima H, Ishii K, Ikeda M.
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Journal Title
Psychogeriatrics
Volume: -
Issue: 6
Pages: 557-565
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] EEG Resting-State Networks in Dementia with Lewy Bodies Associated with Clinical Symptoms.2019
Author(s)
Aoki Y, Kazui H, Pascal-Marqui RD, Ishii R, Yoshiyama K, Kanemoto H, Suzuki Y, Sato S, Hata M, Canuet L, Iwase M, Ikeda M.
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Journal Title
Neuropsychobiology
Volume: 77
Issue: 4
Pages: 206-218
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Cerebral blood flow and Alzheimer's disease-related biomarkers in cerebrospinal fluid in idiopathic normal pressure hydrocephalus.2019
Author(s)
Azuma S, Kazui H, Kanemoto H, Suzuki Y, Sato S, Suehiro T, Matsumoto T, Yoshiyama K, Kishima H, Shimosegawa E, Tanaka T, Ikeda M.
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Journal Title
Psychogeriatrics.
Volume: 印刷中
Issue: 6
Pages: 527-538
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Usefulness of carer-held records to support informal caregivers of patients with dementia who live at home.2018
Author(s)
Sato S, Kazui H, Shimizu Y, Yoshida T, Yoshiyama K, Kanemoto H, Suzuki Y, Morikami T, Fujisue H, Tanaka T, Ikeda M.
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Journal Title
Psychogeriatrics. 2018 Feb 6.
Volume: 16
Issue: 3
Pages: 154-164
DOI
Related Report
Peer Reviewed
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[Journal Article] EEG Resting-State Networks Responsible for Gait Disturbance Features in Idiopathic Normal Pressure Hydrocephalus2018
Author(s)
Aoki Y, Kazui H, Pascual-Marqui RD, Ishii R, Yoshiyama K, Kanemoto H, Suzuki Y, Sato S, Azuma S, Suehiro T, Matsumoto T, Hata M, Canuet L, Iwase M, Ikeda M
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Journal Title
Clinical EEG and Neuroscience
Volume: 50
Issue: 3
Pages: 210-218
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Apathy and right caudate perfusion in idiopathic normal pressure hydrocephalus: a case-control study.2018
Author(s)
Kanemoto H, Kazui H, Suehiro T, Kishima H, Suzuki Y, Sato S, Azuma S, Matsumoto T, Yoshiyama K, Shimosegawa E, Tanaka T, Ikeda M.
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Journal Title
Int J Geriatr Psychiatry.
Volume: 26
Issue: 3
Pages: 453-462
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Neural Basis of Apathy in Patients with Amnestic Mild Cognitive Impairment2017
Author(s)
Kazui H, Takahashi R, Yamamoto Y, Yoshiyama K, Kanemoto H, Suzuki Y, Sato S, Azuma S, Suehiro T, Shimosegawa E, Ishii K, Tanaka T.
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Journal Title
J Alzheimers Dis.
Volume: 55(4)
Issue: 4
Pages: 1403-1416
DOI
Related Report
Peer Reviewed
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[Journal Article] Use of T1-weighted/T2-weighted magnetic resonance ratio to elucidate changes due to amyloid-β accumulation in cognitively normal subjects.2016
Author(s)
Yasuno F, Kazui H, Morita N, Kajimoto K, Ihara M, Taguchi A, Yamamoto A, Matsuoka K, Takahashi M, Nakagawara J, Iida H, Kishimoto T, Nagatsuka K
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Journal Title
Neuroimage Clin
Volume: 13
Pages: 209-214
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] High amyloid-β deposition related to depressive symptoms in older individuals with normal cognition: A pilot study2016
Author(s)
Yasuno F, Kazui H, Morita N, Kajimoto K, Ihara M, Taguchi A, Yamamoto A, Matsuoka K, Kosaka J, Kudo T, Iida H, Kishimoto T, Nagatsuka K
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Journal Title
Int J Geriatr Psychiatry
Volume: 31
Issue: 8
Pages: 920-928
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Differences of Behavioral and Psychological Symptoms of Dementia in Disease Severity in Four Major Dementias2016
Author(s)
Kazui H, Yoshiyama K, Kanemoto H, Suzuki Y, Sato S, Hashimoto M, Ikeda M, Tanaka H, Hatada Y, Matsushita M, Nishio Y, Mori E, Tanimukai S, Komori K, Yoshida T, Shimizu H, Matsumoto T, Mori T, Kashibayashi T, Yokoyama K, Shimomura T, Kabeshita Y, Adachi H, Tanaka T
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Journal Title
PLoS One
Volume: 11
Issue: 8
Pages: e0161092-e0161092
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] 特発性正常圧水頭症における髄液シャント術の脳波NPV解析による効果予測2016
Author(s)
青木保典、数井裕光, 石井良平, 吉山顕次, 鐘本英輝, 鈴木由希子, 佐藤俊介, 東眞吾, 末廣聖, 松本拓也, 武者利光, 松崎晴康, 今城郁, 畑真弘, 池田俊一郎, 岩瀬真生, 池田学
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Journal Title
老年精神医学雑誌
Volume: 27
Pages: 1176-1182
Related Report
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[Presentation] The changes of brain morphology in the patients of the preclinical stage of idiopathic normal pressure hydrocephalus,2017
Author(s)
Suehiro T, Kazui H, Matsumoto T, Azuma S, Sato S, Kanemoto H, Yoshiyama K, Yamashita F, Kishima H, Ikeada M
Organizer
11th International Congress of the Asian Society Against Dementia, Bangkok, 2017 (oral presentation)
Related Report
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[Presentation] Neuroanatomical bases of lower psychomotor speed and gait disturbance in idiopathic normal pressure hydrocephalus.2017
Author(s)
Sato S, Kazui H, Kanemoto H, Azuma S, Suehiro T, Suzuki Y, Matsumoto T, Yoshiyama K, Kishima H, Ikeda M
Organizer
The Ninth Annual Meeting of the International Society for Hydrocephalus and Cerebrospinal Fluid Disorders (ISHCSF), Kobe, 2017.9.23, (oral presentation)
Related Report
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[Presentation] Cerebral metabolism related to sleep disturbances in patients with dementia with Lewy bodies: An open-label study.2017
Author(s)
Kanemoto H, Kazui H, Adachi H, Yoshiyama K, Wada T, Tokumasu Nomura K, Tanaka T, Ikeda M
Organizer
Faculty of Psychiatry of Old Age CONFERENCE 2017 (International Psychogeriatric Association), Queenstown, New Zealand, 2017.11.10, Poster presentation
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