Excitability and inhibitory neural function of psychiatric disorders-MEG study

• Project/Area Number: 16K10217
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Kyushu University
• Principal Investigator: Onitsuka Toshiaki 九州大学, 医学研究院, 准教授 (00398059)
• Research Collaborator: Nakamura Itta ; Hirano Yoji ; Hirano Shogo ; Hirakawa Noriaki ; Kuga Hironori ; Nakanishi Shoichiro ; Takahashi Junichi ; Kitajima Kazutoshi
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 統合失調症 / 双極性障害 / うつ病 / 神経振動 / 神経生理 / 精神疾患 / 聴覚定常状態反応 / 脳磁図

Outline of Final Research Achievements

Evoked auditory steady-state response (ASSR) mainly reflects inhibitory neural function, and spontaneous gamma activity is considered to mainly reflect excitatory neural function.
ASSRs of 54 schizophrenia, 32 bipolar disorder, 22 depression, and 62 healthy subjects were recorded and analyzed using a whole head magnetoencephalography. According to the results of this study, in schizophrenia, impairment of the balance between excitatory and inhibitory neural functions is remarkable. For bipolar disorder, the pattern is mild but the pattern is close to schizophrenia. Patients with depression seem to be close to healthy subjects.

Academic Significance and Societal Importance of the Research Achievements

本研究の結果から、精神疾患を興奮性・抑制性神経機能という観点から、再分類できると思われる。統合失調症では、興奮性・抑制性神経機能のバランスの障害が顕著で、双極性障害はその程度が軽いが統合失調症に近いパターンであり、うつ病は興奮性・抑制性神経機能のバランスの観点からは、健常者に近い。将来的に、客観的診断の補助としてこの研究成果が役立つ可能性がある。

Research Products

• [Journal Article] Neuroanatomical substrate of chronic psychosis in epilepsy: an MRI study (2019)
  • Author(s): Hirakawa Noriaki、Kuga Hironori、Hirano Yoji、Sato Jinya、Oribe Naoya、Nakamura Itta、Hirano Shogo、Ueno Takefumi、Oda Yuko、Togao Osamu、Hiwatashi Akio、Honda Hiroshi、Kanba Shigenobu、Onitsuka Toshiaki
  • Journal Title: Brain Imaging and Behavior Volume: In Press Issue: 5 Pages: 1382-1387
  • DOI: 10.1007/s11682-019-00044-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Progressive reduction of auditory evoked gamma in first episode schizophrenia but not clinical high risk individuals (2019)
  • Author(s): Oribe Naoya、Hirano Yoji、del Re Elisabetta、Seidman Larry J.、Mesholam-Gately Raquelle I.、Woodberry Kristen A.、Wojcik Joanne D.、Ueno Takefumi、Kanba Shigenobu、Onitsuka Toshiaki、Shenton Martha E.、Goldstein Jill M.、Niznikiewicz Margaret A.、McCarley Robert W.、Spencer Kevin M.
  • Journal Title: Schizophrenia Research Volume: In Press Pages: 145-152
  • DOI: 10.1016/j.schres.2019.03.025
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Phase-Amplitude Coupling of the EEG in the Auditory Cortex in Schizophrenia (2018)
  • Author(s): Hirano S, Nakhnikian A, Hirano Y, Oribe N, Kanba S, Onitsuka T, Levin M, Spencer KM
  • Journal Title: Biol Psychiatry Cogn Neurosci Neuroimaging Volume: 3 Issue: 1 Pages: 69-76
  • DOI: 10.1016/j.bpsc.2017.09.001
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Abnormalities of eye movement are associated with work hours in schizophrenia. (2018)
  • Author(s): Morita K, Miura K, Fujimoto M, Shishido E, Shiino T, Takahashi J, Yamamori H, Yasuda Y, Kudo N, Hirano Y, Koshiyama D, Okada N, Ikeda M, Onitsuka T, Ozaki N, Kasai K, Hashimoto R.
  • Journal Title: Schizophr Res Volume: 202 Pages: 420-422
  • DOI: 10.1016/j.schres.2018.06.064
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Estimated cognitive decline in patients with schizophrenia: A multicenter study. (2017)
  • Author(s): Fujino H, Sumiyoshi C, Yasuda Y, Yamamori H, Fujimoto M, Fukunaga M, Miura K, Takebayashi Y, Okada N, Isomura S, Kawano N, Toyomaki A, Kuga H, Isobe M, Oya K, Okahisa Y, Takaki M, Hashimoto N, Kato M, Onitsuka T, Ueno T, Ohnuma T, Kasai K, Ozaki N, Sumiyoshi T, Imura O, Hashimoto R
  • Journal Title: sychiatry Clin Neurosci. Volume: 印刷中 Issue: 5 Pages: 294-300
  • DOI: 10.1111/pcn.12474
  • Peer Reviewed / Open Access
• [Journal Article] Altered sulcogyral patterns of orbitofrontal cortex in a large cohort of patients with schizophrenia (2017)
  • Author(s): Isomura S, Hashimoto R, Nakamura M, Yamashita F, Jimbo S, Hirano Y, Yamamori H, Fujimoto M, Yasuda Y, Mears R, Onitsuka T
  • Journal Title: nature partner journal Schizophrenia Volume: 3 Issue: 1 Pages: 1-4
  • DOI: 10.1038/s41537-016-0008-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Right hemisphere pitch-mismatch negativity reduction in patients with major depression: An MEG study. (2017)
  • Author(s): Hirakawa N, Hirano Y, Nakamura I, Hirano S, Sato J, Oribe N, Ueno T, Kanba S, Onitsuka T.
  • Journal Title: J Affect Disord. Volume: 215 Pages: 225-229
  • DOI: 10.1016/j.jad.2017.03.046
  • Peer Reviewed
• [Journal Article] Increased BOLD Signals Elicited by High Gamma Auditory Stimulation of the Left Auditory Cortex in Acute State Schizophrenia. (2016)
  • Author(s): Kuga H, Onitsuka T, Hirano Y, Nakamura I, Oribe N, Mizuhara H, Kanai R, Kanba S, Ueno T
  • Journal Title: EBioMedicine Volume: 12 Pages: 143-149
  • DOI: 10.1016/j.ebiom.2016.09.008
  • NAID: 120005997816
  • Peer Reviewed / Open Access
• [Presentation] てんかん、てんかん性精神病の構造MRI研究. (2018)
  • Author(s): 鬼塚俊明
  • Organizer: 第114回日本精神神経学会学術総会（シンポジウム）
• [Presentation] The anatomical and functional substrate of auditory hallucinations in patients with schizophrenia. (2018)
  • Author(s): Onitsuka T
  • Organizer: 第40回日本生物学的精神医学会・第61回日本神経化学会大会 合同年会（シンポジウム）.
• [Presentation] 統合失調症. (2018)
  • Author(s): 鬼塚俊明
  • Organizer: 第40回日本生物学的精神医学会・第61回日本神経化学会大会 合同年会（教育講演）.
  • Invited
• [Presentation] 急性期統合失調症における左聴覚野の過剰反応 (2017)
  • Author(s): 鬼塚俊明、久我弘典、平野羊嗣、神庭重信、上野雄文
  • Organizer: 第12回日本統合失調症学会
  • Place of Presentation: 鳥取県
  • Year and Date: 2017-03-24
• [Presentation] 急性期統合失調症における左聴覚野の過剰反応 (2017)
  • Author(s): 鬼塚俊明、久我弘典、平野羊嗣、神庭重信、上野雄文
  • Organizer: 第12回日本統合失調症学会（シンポジウム）
• [Presentation] Neural dynamics in psychiatric disorders (2017)
  • Author(s): Onitsuka T
  • Organizer: Biomagnetic Sendai 2017 (Symposium)
  • Int'l Joint Research
• [Presentation] 急性期統合失調症における断続クリック音に対するBOLD反応 (2016)
  • Author(s): 鬼塚俊明、久我弘典、上野雄文、平野羊嗣、神庭重信
  • Organizer: 第46回日本臨床神経生理学会学術大会
  • Place of Presentation: 福島県
  • Year and Date: 2016-10-27
• [Book] Clinical Applications of Magnetoencephalography (2016)
  • Author(s): Onitsuka T, Hirano S
  • Total Pages: 14
  • Publisher: Springer