Clinical evaluation of preclinical Alzheimer's disease in patients with subjective cognitive decline
| Project/Area Number |
16K10223
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Keio University |
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Principal Investigator |
Tabuchi Hajime 慶應義塾大学, 医学部(信濃町), 講師 (10286578)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 自覚的認知機能低下 / アミロイドPET / 神経心理学的検査 / 告知 / アルツハイマー型認知症 / 発症前診断 / アルツハイマー病 / 発症前 / 自覚 / 精神症状 / 病名告知 |
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| Outline of Final Research Achievements |
The present study found that Aβ accumulation in cognitively normal research participants with subjective cognitive decline (SCD) might be predicted by the score change from immediate recall to delayed recall of the logical memory, whereas no significant differences were observed between Aβ-positive and negative SCD groups. Also, subjective memory decline correlated with verbal fluency and amotivation in Aβ-negative individuals with SCD.
Disclosing amyloid status to SCD did not cause significant long-term psychological risks. However, our findings suggested that those who fill criteria of SCD will include a possible high-risk subgroup for exacerbated distress after learning their negative amyloid PET results. Participants with high levels of anxiety before enrolment were more likely to have test-related distress one year after learning their amyloid negative results.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の成果は、現在臨床的には判断の難しいADの発症前診断について、低いコストでより幅広い対象者に対して実施できる、いわばスクリーニング検査的な役割につながる、重要な知見となることが期待される。また将来的に利用が広がると思われるPET検査等の発症前診断においては、告知の問題が未だほとんど調査されていない。本研究により告知の安全性が確認されたことが、今後おそらく利用が広がると思われる発症前診断を適切に実施するための、有用な知見になると期待される。
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Can we predict amyloid deposition by objective cognition and regional cerebral blood flow in patients with subjective cognitive decline?2019
Author(s)
Funaki K, Nakajima S, Noda Y, Wake T, Ito D, Yamagata B, Yoshizaki T, Kameyama M, Nakahara T, Murakami K, Jinzaki M, Mimura M, Tabuchi H.
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Journal Title
Psychogeriatrics
Volume: AOP
Issue: 4
Pages: 325-332
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Extremely Low Prevalence of Amyloid Positron Emission Tomography Positivity in Parkinson's Disease without Dementia.2017
Author(s)
Mashima K, Ito D, Kameyama M, Osada T, Tabuchi H, Nihei Y, Yoshizaki T, Noguchi E, Tanikawa M, Iizuka T, Date Y, Ogata Y, Nakahara T, Iwabuchi Y, Jinzaki M, Murakami K, Suzuki N
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Journal Title
Eur Neurol
Volume: 77
Issue: 5-6
Pages: 231-237
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] Disclosure of amyloid status for risk of Alzheimer’s disease to cognitively normal persons with subjective cognitive decline2018
Author(s)
Wake T, Tabuchi H, Funaki K, Ito D, Yamagata B, Yoshizaki T, kameyama M, Nakahara T, Murakami K, Jinzaki M, Yoshimasu H, Tanahashi I, Shimazaki H, Mimura M
Organizer
Alzheimer’s Association International Conference 2018, 2018.7.22-26, Chicago, USA
Related Report
Int'l Joint Research
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[Presentation] Increased PET-detectable tau pathologies in late-life depression with psychosis2017
Author(s)
Moriguchi S, Takahata K, Shimada H, Kimura Y, Kubota M, Kitamura S, Ishii T, Takado Y, Tagai K, Nakajima S, Tarumi R, Tabuchi H, Mimura M, Suhara T, Higuchi M
Organizer
2017 Society of Biological Psychiatry Annual Meeting
Related Report
Int'l Joint Research
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[Presentation] Delayed-onset psychosis following TBI is associated with tau depositions in the neocortex but not with β-amyloid depositions: A PET study with [11C]PBB3 and [11C]PiB2017
Author(s)
Takahata K, Kimura Y, Shimada H, Ichise M, Tabuchi H, Kitamura S, Kubota M, Moriguchi S, Ishii T, Niwa F, Endo H, Morimoto Y, Funayama M, Onaya M, Sahara N, SUmeda S, Mimura M, Higuchi M, Suhara T
Organizer
2017 Society of Biological Psychiatry Annual Meeting
Related Report
Int'l Joint Research
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