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A development of cognitive remediation therapy for eating disorders, neurodevelopmental disorders in adolescence

Research Project

Project/Area Number 16K10241
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionChiba University

Principal Investigator

Nakazato Michiko  千葉大学, 大学院医学研究院, 特任教授 (10334195)

Project Period (FY) 2016-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords児童思春期 / 神経性やせ症 / 認知柔軟性 / 統合的一貫性 / 集団療法 / 認知機能改善療法 / セントラルコヒアレンス / 神経心理学 / 摂食障害 / 集団精神療法 / 認知機能 / 自閉スペクトラム症 / 脳神経基盤
Outline of Final Research Achievements

Cognitive remediation therapy (CRT) aims to increase cognitive flexibility by practicing new ways of thinking, facilitating bigger picture thinking, supporting patients with relevant tasks and encouraging an awareness of their own thinking styles. The aim of this study was to test the efficacy of a CRT group for adolescents with AN. 4 sessions of Group CRT interventions were carried out in the adolescent inpatients with anorexia nervosa (AN). The average age of the participants was 14.7 (1.6SD) years old. Neuropsychological and psychological assessments (motivation, self-efficacy and depression) were administered before and after the group intervention. There was a significant improvement of BMI, as well as the changes of cognitive flexibility, using the Brixton tests. The Group-CRT was shown to be effective in improving cognitive flexibility, increase Body Mass Index (BMI). In conclusion, CRT groups are acceptable for younger adolescents with AN in a Japanese sample.

Academic Significance and Societal Importance of the Research Achievements

児童思春期の神経性やせ症の認知特性として、認知柔軟性の障害、統合的一貫性(セントラルコヒアレンス)の障害に関連した脳神経基盤が明らかになった。本研究では、児童思春期の神経性やせ症入院患者を対象とした集団認知機能改善療法(Group-Cognitive Remediation Therapy; G-CRT)を用いて、治療前後のBMIの改善、認知柔軟性の改善の効果が明らかにされた。児童思春期の神経性やせ症の認知柔軟性の障害、およびGCRTの有効性が明らかにされた。集団認知機能改善療法は、児童思春期の神経性やせ症に対する低体重の改善、健康増進、心理社会的機能の向上が期待される。

Report

(6 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (15 results)

All 2021 2020 2019 2018 2017 2016

All Journal Article (7 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 6 results,  Open Access: 3 results) Presentation (7 results) (of which Int'l Joint Research: 4 results,  Invited: 3 results) Book (1 results)

  • [Journal Article] Establishment of a Japanese version of the Sick, Control, One Stone, Fat, and Food (SCOFF) questionnaire for screening eating disorders in university students2021

    • Author(s)
      Hosoda Yutaka、Ohtani Toshiyuki、Hanazawa Hisashi、Tanaka Mami、Kimura Hiroshi、Ohsako Noriaki、Hashimoto Tasuku、Kobori Osamu、Iyo Masaomi、Nakazato Michiko
    • Journal Title

      BMC Research Notes

      Volume: 14 Issue: 1 Pages: 142-142

    • DOI

      10.1186/s13104-021-05549-0

    • URL

      https://pure.teikyo.jp/en/publications/410466e6-0c34-408b-af3a-366a90e7742b

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] COVID Isolation Eating Scale ( CIES ): Analysis of the impact of confinement in eating disorders and obesity?A collaborative international study2020

    • Author(s)
      Fernndez‐Aranda Fernando, et al.
    • Journal Title

      European Eating Disorders Review

      Volume: 28 Issue: 6 Pages: 871-883

    • DOI

      10.1002/erv.2784

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hemodynamic responses in prefrontal cortex and personality characteristics in patients with bulimic disorders: a near-infrared spectroscopy study.2018

    • Author(s)
      Numata N, Hirano Y, Sutoh C, Matsuzawa D, Takeda K, Setsu R, Shimizu E, Nakazato M.
    • Journal Title

      Eat Weight Disord, in press

      Volume: - Issue: 1 Pages: 1-9

    • DOI

      10.1007/s40519-018-0500-7

    • Related Report
      2020 Annual Research Report 2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] A single-arm pilot study of guided self-help treatment based cognitive behavioral therapy for bulimia nervosa in Japanese clinical settings2018

    • Author(s)
      Setsu R, Asano K, Numata N, Tanaka M, Ibuki H, Yamamoto T, Uragami R, Matsumoto J, Hirano Y, Iyo M, Shimizu E, Nakazato M.
    • Journal Title

      BMC Res Notes.

      Volume: Apr 25;11(1) Issue: 1 Pages: 257-257

    • DOI

      10.1186/s13104-018-3373-y

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Group cognitive remediation therapy for younger adolescents with anorexia nervosa: a feasibility study in a Japanese sample2017

    • Author(s)
      Kuge Rie、Lang Katie、Yokota Ayano、Kodama Shoko、Morino Yuriko、Nakazato Michiko、Shimizu Eiji
    • Journal Title

      BMC Research Notes

      Volume: 10 Issue: 1 Pages: 2-7

    • DOI

      10.1186/s13104-017-2642-5

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 児童期・思春期のやせ―神経性やせ症と回避・制限性食物摂取症-2017

    • Author(s)
      中里道子、公家理依
    • Journal Title

      精神科治療学

      Volume: 32(1) Pages: 111-116

    • Related Report
      2016 Research-status Report
  • [Journal Article] Altered serum level of matrix metalloproteinase-9 and its association with decision-making in eating disorders2017

    • Author(s)
      Matsumoto J, Hirano Y, Hashimoto K, Ishima T, Kanahara N, Niitsu T, Shiina A, Hashimoto T, MD, Sato Y, Yokote K, Murano S, KimuraH, Hosoda Y, Shimizu E, Iyo M, and Nakazato M
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 71 Issue: 2 Pages: 124-134

    • DOI

      10.1111/pcn.12490

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] DEVELOPMENT OF AN ONLINE GUIDED SELF-HELP COGNITIVE BEHAVIORAL THERAPY FOR BULIMIA NERVOSA IN JAPANESE CLINICAL SETTINGS: A FEASIBILITY STUDY.2020

    • Author(s)
      Noriaki Ohsako, Hiroshi Kimura, Tony Lam, Tasuku Hashimoto, Yutaka Hosoda, Yosuke Inaba, Masaomi Iyo, Michiko Nakazato
    • Organizer
      Eating Disorders Research Society
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 摂食障害への初期対応2020

    • Author(s)
      中里道子
    • Organizer
      第116回日本精神神経学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 摂食障害の早期発見と早期対応2020

    • Author(s)
      中里道子
    • Organizer
      第61回日本児童青年精神医学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Development of online check-up system of eating problems and self-help program for bulimia nervosa and binge eating disorders.2019

    • Author(s)
      Nakazato M
    • Organizer
      2019 International Congress in Obesity and Metabolic Syndrome& Asia-Oceania Conference in Obesity
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Group Cognitive Remediation Therapy for Japanese Adolescents with Anorexia Nervosa2019

    • Author(s)
      Rie Kuge, Ayano Yokota, Yuriko Morino, Michiko Nakazato
    • Organizer
      International Conference on Eating Disorders2019
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 神経性やせ症に対する認知機能改善療法2018

    • Author(s)
      中里道子、公家里依
    • Organizer
      第114回日本摂食障害学会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Evaluation of a cognitive remediation therapy group for adolescents with anorexia nervosa: an open study.2016

    • Author(s)
      Kuge R, Yokota A, Numata N, Okuda T, Nakazato M.
    • Organizer
      The 22nd international association for child and adolescent psychiatry and allied professions world congress (IACAPAP)
    • Place of Presentation
      Calgary, Canada
    • Year and Date
      2016-09-18
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Book] モーズレイ神経性やせ症治療 MANTRAワークブック2021

    • Author(s)
      中里 道子、友竹 正人、水原 祐起
    • Total Pages
      320
    • Publisher
      南山堂
    • ISBN
      9784525381912
    • Related Report
      2020 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2022-01-27  

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