A clinicat study for the prediction using MRI images and pharamacological prevention
| Project/Area Number |
16K10245
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Kurumaji Akeo 東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師 (00251504)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | せん妄 / MRI 検査 / 予測因子 / 術後せん妄 / MRI検査 / 頭部MRI / 準備因子 / SPM / 核磁気共鳴検査 / 脳画像情報 / リエゾン精神医学 / 心臓手術 |
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| Outline of Final Research Achievements |
Delirium is a common neurobehavioral disturbance in older patients after surgery. In the present study, the patients with the age range from 58 to 87 underwent an elective cardiac operation during 2 periods, i.e., August 2005 ~ August 2006 and July 2016 - December 2018. The total subjects included in the two studies were 175. Before the surgery, an MRI study was conducted. The MRI data were processed to calculate the absolute volumes of the pre-defined region of interest using SPM-8. The delirium was diagnosed according to the DSM-IV criteria.
The present study revealed that thirty-two of the 175 patients (18.3%) developed delirium. Based on a comparison to the age-controlled non-delirium patients, a statistically significant reduction in the GM volume of the delirium patients was observed in the widespread cerebral cortices as well as in the cerebellum. Hence, the atrophic change in the GM can be associated with the vulnerability to delirium after cardiac surgery.
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| Academic Significance and Societal Importance of the Research Achievements |
これまで、術後せん妄の発症に、脳の形態学的な変化がどのように関与しているかは、あまり詳細には研究されていなかった。我々は、この疑問に関して、先行研究において、８４名の患者に関する研究を行ない、学術雑誌に報告しているが、本研究では、新たに９１名の患者に関する研究を行い、このふたつの研究を合わせることにより、１７５名というより多数の症例を検討することができた。
本研究は、大脳皮質、特に側頭葉の灰白質の体積の減少は、心臓血管手術後のせん妄の予測因子として重要なものであると同時に、せん妄発症への脆弱性およびその病態生理に関与していることを示唆する重要なものである。
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Report
(5 results)
Research Products
(21 results)
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[Journal Article] Association studies of WD repeat domain 3 and chitobiosyldiphosphodolichol beta- mannosyltransferase genes with schizophrenia in a Japanese population.2018
Author(s)
Momoko Kobayashi, Daisuke Jitoku, Yoshimi Iwayama, Naoki Yamamoto, Tomoko Toyota, Katsuaki Suzuki, Mitsuru Kikuchi, Tasuku Hashimoto, Nobuhisa Kanahara, Akeo Kurumaji, Takeo Yoshikawa, Toru Nishikawa
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Journal Title
PLoS ONE
Volume: 13
Issue: 1
Pages: e0190991-e0190991
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Association of schizophrenia onset age and white matter integrity with treatment effect of D-cycloserine: a randomized placebo- controlled double-blind crossover study2017
Author(s)
Kazuo Takiguchi, Akihito Uezato, Michio Itasaka, Hidenori Atsuta, Kenji Narushima, Naoki Yamamoto, Akeo Kurumaji, Makoto Tomita, Kazunari Oshima, Kosaku Shoda, Mai Tamaru, Masahito Nakataki, Mitsutoshi Okazaki, Sayuri Ishiwata, Yasuyoshi Ishiwata, Masato Yasuhara, Kunimasa Arima,Tetsuro Ohmori, Toru Nishikawa
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Journal Title
BMC Psychiatry,
Volume: 17
Issue: 1
Pages: 249-263
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Genetic and molecular risk factors within the newly identified primate-specific exon of the SAP97/DLG1 gene in the 3q29 schizophrenia-associated locus.2017
Author(s)
Akihito Uezato, Naoki Yamamoto, Daisuke Jitoku, Emiko Haramo, Eri Hiraaki, Yoshimi Iwayama, Tomoko Toyota, Masakazu Umino, Asami Umino, Yasuhide Iwata, Katsuaki Suzuki, Mitsuru Kikuchi, Tasuku Hashimoto, Nobuhisa Kanahara, Akeo Kurumaji, Takeo Yoshikawa, Toru Nishikawa.
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Journal Title
American Journal of Medical Genetics(Part B): Neuropsychiatric_Genetics,
Volume: 174
Issue: 8
Pages: 798-804
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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