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Auditory processing related to language acquisition and auditory hypersensitivity in children with autism spectrum disorder

Research Project

Project/Area Number 16K10247
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionKanazawa University

Principal Investigator

YUSHIMURA Yuko  金沢大学, 人間社会研究域, 准教授 (70597070)

Co-Investigator(Kenkyū-buntansha) 林 則夫  群馬県立県民健康科学大学, 診療放射線学部, 准教授 (50648459)
Research Collaborator KIKUCHI Mitsuru  
TAKAHASHI Tetsuya  
MUNESUE Toshio  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords自閉スペクトラム症 / 聴覚処理 / 脳磁図 / 脳磁図(MEG) / 聴覚反応 / 聴覚情報処理 / 幼児 / 脳磁計(MEG) / 言語発達 / 脳磁計 / 聴覚誘発反応
Outline of Final Research Achievements

We investigated the brain response to the sound stimulation using the child-customized magnetoencephalography (MEG) for children with autism spectrum disorder (ASD) and typical developing (TD) children. We also performed auditory tests to investigate the function of central processing from the peripherical function in auditory information processing. As a result,hearing threshold was significantly higher in the left ear in ASD group than in the tipical developing children group (P = 0.025). In the brain responses evoked by auditory stimuli (i.e. P1m), there was no significant difference between ASD group and TD group in both hemispheres.

Academic Significance and Societal Importance of the Research Achievements

本研究は、就学前の自閉スペクトラム症児と定型発達児を対象に、音に対する反応を自分で応答する必要のある聴力検査と内耳、脳幹、脳皮質の反応を捉える他覚的な検査で調べた。その結果、自覚的な聴力検査である純音聴力検査において、自閉スペクトラム症児は定型発達児群よりも反応が乏しいという結果であった。一方で、脳幹や脳皮質の反応では、両群の間に有意な差はみられなかった。今回の結果には、音に対して発声やボタン押しで応じるという課題への注意持続力の問題なども影響していることが考えられる。さらに他の脳反応にも着目して検討することにより、自閉症と定型発達児の聴覚情報処理の特性を明らかにすることができると考えられる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (19 results)

All 2018 2017 2016

All Journal Article (9 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 9 results,  Open Access: 4 results,  Acknowledgement Compliant: 1 results) Presentation (10 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results)

  • [Journal Article] Longitudinal changes in the mismatch field evoked by an empathic voice reflect changes in the empathy quotient in autism spectrum disorder.2018

    • Author(s)
      Yoshimura Y, Kikuchi M, Hiraishi H, Hasegawa C, Hirosawa T, Takahashi T, Munesue T, Kosaka H, Hiagashida H, Minabe Y
    • Journal Title

      Psychiatry Res Neuroimaging

      Volume: 30 Pages: 117-122

    • DOI

      10.1016/j.pscychresns.2018.05.003

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Altered human voice processing in the frontal cortex and a developmental language delay in 3- to 5-year-old children with autism spectrum disorder2017

    • Author(s)
      Yoshimura Yuko、Kikuchi Mitsuru、Hayashi Norio、Hiraishi Hirotoshi、Hasegawa Chiaki、Takahashi Tetsuya、Oi Manabu、Remijn Gerard B.、Ikeda Takashi、Saito Daisuke N.、Kumazaki Hirokazu、Minabe Yoshio
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 17116-17116

    • DOI

      10.1038/s41598-017-17058-x

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] pilot study of serotonergic modulation after long-term administration of oxytocin in autism spectrum disorder.2017

    • Author(s)
      Hirosawa T, Kikuchi M, Ouchi Y, Takahashi T, Yoshimura Y, Kosaka H, Furutani N, Hiraishi H, Fukai M, Yokokura M, Yoshikawa E, Bunai T, Minabe Y.
    • Journal Title

      Autism Res.

      Volume: - Issue: 5 Pages: 113-117

    • DOI

      10.1002/aur.1761

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Near-Infrared Spectroscopy Study on Cortical Hemodynamic Responses to Normal and Whispered Speech in 3- to 7-Year-Old Children.2017

    • Author(s)
      Remijn GB, Kikuchi M, Yoshimura Y, Shitamichi K, Ueno S, Tsubokawa T, Kojima H, Higashida H, Minabe Y
    • Journal Title

      Lang Hear Res.

      Volume: 1 Pages: 465-470

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mu rhythm suppression reflects mother-child face-to-face interactions: a pilot study with simultaneous MEG recording2016

    • Author(s)
      Hasegawa C, Ikeda T, Yoshimura Y, Hiraishi H, Takahashi T, Furutani N, Hayashi N, Minabe Y, Hirata M, Asada M, Kikuchi M
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 34977-34977

    • DOI

      10.1038/srep34977

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Contribution of Increased Gamma Band Connectivity to Visual Non-Verbal Reasoning in Autistic Children: A MEG Study.2016

    • Author(s)
      Takesaki N, Kikuchi M, Yoshimura Y, Hiraishi H, Hasegawa C, Kaneda R, Nakatani H, Takahashi T, Mottron L, Minabe Y.
    • Journal Title

      PLoS One.

      Volume: -

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Characteristics of Communication among Japanese Children with Autism Spectrum Disorder: A Cluster Analysis Using the Children’s Communication Checklist-22016

    • Author(s)
      Tanaka S, Oi M, Fujino H, Kikuchi M, Yoshimura Y, Miura Y, Tsujii M, Ohoka H.
    • Journal Title

      Clinical Linguistics & Phonetics

      Volume: 14 Pages: 1-16

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Synchrony of auditory brain responses predicts behavioral ability to keep still in children with autism spectrum disorder: Auditory-evoked response in children with autism spectrum disorder.2016

    • Author(s)
      Yoshimura Y, Kikuchi M, Hiraishi H, Hasegawa C, Takahashi T, Remijn GB, Oi M, Munesue T, Higashida H, Minabe Y.
    • Journal Title

      Neuroimage Clin.

      Volume: 22 Pages: 300-305

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Atypical Bilateral Brain Synchronization in the Early Stage of Human Voice Auditory Processing in Young Children with Autism.2016

    • Author(s)
      Kurita T, Kikuchi M, Yoshimura Y, Hiraishi H, Hasegawa C, Takahashi T, Hirosawa T, Furutani N, Higashida H, Ikeda T, Mutou K, Asada M, Minabe Y.
    • Journal Title

      PLoS One

      Volume: 13 Issue: 4 Pages: 0153077-0153077

    • DOI

      10.1371/journal.pone.0153077

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 小児のMEG 研究から見えてきた発達障害の多様性2018

    • Author(s)
      吉村優子
    • Organizer
      脳磁図トポグラフィ学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 言語発達の神経基盤2018

    • Author(s)
      吉村優子
    • Organizer
      次世代脳プロジェクト冬のシンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 発達障害がある子どもたちの聴覚情報処理の特性2018

    • Author(s)
      吉村優子
    • Organizer
      第1回COI学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 幼児における聴覚誘発磁場と言語発達2018

    • Author(s)
      吉村優子
    • Organizer
      特殊教育学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Effects of oxytocin on social auditory processing and empathy in male adults with autism spectrum disorder2018

    • Author(s)
      Yuko Yoshimura
    • Organizer
      Biomag
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Impaired Frontal Processing in 3- to 5-Year-Old Children with Autism and Developmental Language Delay during a Mismatch Negativity Paradigm.2017

    • Author(s)
      Yuko Yoshimura, Mitsuru Kikuchi, Chiaki Hasegawa, Hirotoshi Hiraishi, Sachiko Kitagawa, Takashi Ikeda, Hirokazu Kumazaki, Yoshio Minabe
    • Organizer
      International Society for Autism Research 2017 meeting
    • Related Report
      2017 Research-status Report
  • [Presentation] Atypical development of the central auditory system in young children with autism spectrum disorder2016

    • Author(s)
      Yuko Yoshimra
    • Organizer
      The 3rd International Symposium on Cognitive Neuroscience Robotics: Toward Constructive Developmental Science
    • Place of Presentation
      大阪
    • Year and Date
      2016-12-11
    • Related Report
      2016 Research-status Report
  • [Presentation] 幼児期の人の声に対する脳反応と言語発達-定型発達と自閉スペクトラム症の研究から-2016

    • Author(s)
      吉村優子
    • Organizer
      保育と音環境シンポジウム
    • Place of Presentation
      金沢
    • Year and Date
      2016-12-10
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 注視点検出法(機)を導入した自治体乳幼児健診におけるASD児の早期発見と超早期療育の展望-自閉症の超早期領域ESDMについて2016

    • Author(s)
      吉村優子
    • Organizer
      第15回自閉スペクトラム症学会
    • Place of Presentation
      東京
    • Year and Date
      2016-08-27
    • Related Report
      2016 Research-status Report
  • [Presentation] Atypical development of the central auditory system in young children with autism spectrum disorder2016

    • Author(s)
      吉村優子
    • Organizer
      第31回日本生体磁気学会
    • Place of Presentation
      金沢
    • Year and Date
      2016-06-09
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2020-03-30  

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