Neurobiological basis of autism spectrum disorders focuslng of reflexive responses to social stimuli
| Project/Area Number |
16K10248
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Nagoya University |
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Principal Investigator |
Okada Takashi 名古屋大学, 医学部附属病院, 准教授 (80335249)
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| Co-Investigator(Kenkyū-buntansha) |
鈴木 太 福井大学, 子どものこころの発達研究センター, 准教授 (30542683)
宇野 洋太 名古屋大学, 医学部附属病院, 助教 (40539681)
森川 真子 名古屋大学, 医学系研究科, 寄附講座助教 (60783305)
小川 しおり 名古屋大学, 医学部附属病院, 助教 (60814150)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 自閉スペクトラム症 / 情動的表情認知 / 社会性障害 / 中間表現型 / ゲノムコピー数変異 / アイカメラ / 脳画像 / 表情認識 / 表情表出 / 対人関係障害 / 誤認識パターン / 不適応行動 / 表情認知 / 視線認知 / 反射的応答 |
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| Outline of Final Research Achievements |
Impaired facial expression recognition disorder is considered to be the most core deficits associated with social disturbances in autism spectrum disorders, but it is also recognized in other disorders such as schizophrenia. We sought to identify a specific pattern of facial affect recognition in autism spectrum disorders, which could clarify the relationship between etiology and pathology. Examination of facial expression recognition patterns in adult men with autism spectrum disorder showed cognitive decline of negative emotions such as anger, disgust, and fear. Adninistration of oxytocin reduced misrecognition between anger and disgust. In addition, we identified rare genomic copy number mutations associated with onset of autism spectrum disorders and accumulated brain imaging and fMRI data.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の結果から、自閉スペクトラム症では恐怖と怒りの誤認が認められ、それが社会における不適応行動とも関連する障害特異的な表情認識障害である可能性が示唆された。この結果は中間表現型としての有用性と関連しており、今回明らかにしえた稀なゲノムコピー数変異や集積中の脳画像所見とともに併せて解析することで、診断の細分化、診断基準の明確化、病態と関連した個別医療の可能性に道を開くものと思われる。
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Report
(5 results)
Research Products
(33 results)
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[Journal Article] Methylation analysis for postpartum depression : a case control study.2019
Author(s)
Nakamura Y, Nakatochi M, Kunimoto S, Okada T, Aleksic B, Toyama M, Shiino T, Morikawa M, Yamauchi A, Yoshimi A, Furukawa-Hibi Y, Nagai T, Ohara M, Kubota C, Yamada K, Ando M, Ozaki N.
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Journal Title
BMC Psychiatry.
Volume: 19
Issue: 1
Pages: 190-199
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Effect of intranasal oxytocin on the core social symptoms of autism spectrum disorder: a randomized clinical trial2018
Author(s)
Yamasue H, Okada T, Munesue T, Kuroda M, Fujioka T, Uno Y, Matsumoto K, Kuwabara H, Mori D, Okamoto Y, Yoshimura Y, Kawakubo Y, Arioka Y, Kojima M, Yuhi T, Owada K, Yassin W, Kushima I, Benner S, Ogawa N, Eriguchi Y, Kawano N, Uemura Y, Yamamoto M, Kano Y, Kasai K, Higashida H, Ozaki N, Kosaka H
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Journal Title
Molecular Psychiatry
Volume: Jan
Issue: 8
Pages: 1849-1858
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Aripiprazole in the treatment of irritability in children and adolescents with autism spectrum disorder in Japan: A randomized, double-blind, placebo-controlled study.2016
Author(s)
Ichikawa H, Mikami K, Okada T, Yamashita Y, Ishizaki Y, Tomoda A, Ono H, Usuki C, Tadori Y.
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Journal Title
Child Psychiatry Hum Dev
Volume: 7(6)
Issue: 5
Pages: 841-851
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Investigation of Rare Single-Nucleotide PCDH15 Variants in Schizophrenia and Autism Spectrum Disorders2016
Author(s)
Ishizuka, K., H. Kimura, C. Wang, J. Xing, I. Kushima, Y. Arioka, T. Oya-Ito, Y. Uno, T. Okada, D. Mori, B. Aleksic, and N. Ozaki.
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Journal Title
PLoS One
Volume: 11
Issue: 4
Pages: e0153224-e0153224
DOI
Related Report
Peer Reviewed / Open Access
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[Book] 発達障害白書2019年版2018
Author(s)
會田千重、朝日雅也、阿部達也、岡田俊ほか
Total Pages
200
Publisher
明石書店
ISBN
9784750347202
Related Report
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[Book] こころの医学入門2017
Author(s)
近藤直司、田中康雄、本田秀夫、岡田俊ほか
Total Pages
330
Publisher
中央法規
ISBN
9784805854952
Related Report
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[Book] 明石書店2016
Author(s)
日本発達障害連盟（編）
Total Pages
216
Publisher
発達障害白書2017年版
Related Report
