| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Autism Spectrum Disorder (ASD) is a pervasive developmental disorder defined by social and communication problems and emotional behavior. The etiology of the disease is unknown, even though there are various theories. In order to elucidate the biological pathogenesis of ASD, we developed a mouse model of ASD with the same genetic abnormalities as those frequently seen in human ASD patients, and examined the biological abnormalities. It turns out that this ASD mouse model has a serious developmental ploblems that causes more than 90 percent of its offspring to die shortly after birth. The few individuals that survived were able to reach adulthood despite their low growth, but at the same time they showed ADHD-like behaviors.
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