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Image biomarkers of intrahepatic cholangiocarcinoma based on genetic and biomolecular phenotypes

Research Project

Project/Area Number 16K10272
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionKanazawa University

Principal Investigator

Kazuto Kozaka  金沢大学, 附属病院, 講師 (80547175)

Co-Investigator(Kenkyū-buntansha) 原田 憲一  金沢大学, 医学系, 教授 (30283112)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsMRI / 肝内胆管癌 / FDG-PET/CT / IDH1/2 / グルコーストランスポーター / 腫瘤形成型肝内胆管癌 / IDH / 画像診断 / 腫瘤形成性肝内胆管癌 / CT / EOB造影MRI / 細胆管癌 / OATP1B3 / イメージバイオマーカー
Outline of Final Research Achievements

Intrahepatic cholangiocarcinoma is the second most frequent primary liver cancer after hepatocellular carcinoma, and in recent years the worldwide trend for an increasing number of patients has been observed. Recent gene and molecular biological researches have proposed a subclassification of intrahepatic cholangiocarcinoma, which is important for personalized medicine. Here, we clarified by immunohistochemistry that tumor glucose metabolism was not strongly enhanced in small duct type of cholangiocarcinoma, and found that these can be confirmed by FDG-PET examination. We also found that those with IDH1 / 2 mutations show high ADC values rather than IDH1/2 wild type on MRI examination.

Academic Significance and Societal Importance of the Research Achievements

肝内胆管癌は予後の悪い悪性腫瘍の一つであり、早期に診断して外科治療することがもっとも有効な治療である。しかし、近年肝内胆管癌には少なくとも2つの異なった亜型があることが分かっており、それらの生物学的態度や有効な治療方法も異なっていることが明らかとなっている。これらの亜分類は腫瘍から検体を取り出し、病理学的、遺伝子生物学的に検討する必要がある。本研究ではこれらの亜分類をCTやMRIによる臨床画像で診断ないし類推する可能性を示した。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (11 results)

All 2018 2017 2016

All Journal Article (3 results) (of which Peer Reviewed: 1 results) Presentation (8 results) (of which Int'l Joint Research: 5 results,  Invited: 3 results)

  • [Journal Article] 肝内胆管病変の画像診断2018

    • Author(s)
      小坂一斗
    • Journal Title

      画像診断

      Volume: 38 Pages: 1047-1057

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 胆道狭窄の画像診断2018

    • Author(s)
      小坂一斗
    • Journal Title

      臨床放射線

      Volume: 63 Pages: 885-895

    • NAID

      40021672844

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Dynamic CT findings of cholangiolocellular carcinoma: correlation with angiography-assisted CT and histopathology.2016

    • Author(s)
      Kozaka Kazuto
    • Journal Title

      Abdominal Radiology

      Volume: 42 Issue: 3 Pages: 861-869

    • DOI

      10.1007/s00261-016-0944-z

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] 肝内局在から見た腫瘤形成性肝内胆管癌の画像的特徴と病理分類2018

    • Author(s)
      小坂一斗
    • Organizer
      第54回日本肝癌研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Imaging features of hepatic metastases from various sources: Radiologic -pathologic correlation2018

    • Author(s)
      小坂一斗
    • Organizer
      RSNA
    • Related Report
      2018 Annual Research Report
  • [Presentation] Radiology Update: Acute cholangitis2018

    • Author(s)
      Kazuto Kozaka
    • Organizer
      3rd Dissemination seminar in Myanmar
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Hepatic metastases: Imaging variation and pitfalls2018

    • Author(s)
      Kazuto Kozaka
    • Organizer
      Myanmar Radiology Society
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 細胆管癌の画像的特徴:ダイナミックCTにおける肝細胞癌,胆管細胞癌との対比2017

    • Author(s)
      小坂一斗
    • Organizer
      日本肝癌研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] Sclerosing cholangitis: images and pathophysiology2017

    • Author(s)
      Kazuto Kozaka
    • Organizer
      Radiology society of north America
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Varying 18F-FDG uptake and glucose transporter  expression in mass forming type of intrahepatic cholangiocarcinoma2016

    • Author(s)
      Kazuto Kozaka
    • Organizer
      Radiology society of North America (RSNA)
    • Place of Presentation
      McCormick Place, Chicago
    • Year and Date
      2016-11-28
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Imaging of Intrahepatic Cholangiocarcinoma Up-to-date2016

    • Author(s)
      Kazuto Kozaka
    • Organizer
      German Radiology Congress
    • Place of Presentation
      Congress center Leipzig
    • Year and Date
      2016-05-05
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited

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Published: 2016-04-21   Modified: 2020-03-30  

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