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Vector functional analysis of myocardial wall motion and blood flow

Research Project

Project/Area Number 16K10286
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionYokohama City University (2018-2020)
Kumamoto University (2016-2017)

Principal Investigator

UTSUNOMIYA Daisuke  横浜市立大学, 医学研究科, 教授 (30571046)

Co-Investigator(Kenkyū-buntansha) 福井 寿啓  熊本大学, 大学院生命科学研究部(医), 教授 (50445045)
船間 芳憲  熊本大学, 大学院生命科学研究部(保), 教授 (30380992)
尾田 済太郎  熊本大学, 大学院生命科学研究部(医), 特任講師 (80571041)
木藤 雅文  熊本大学, 病院, 特任助教 (40744909)
中浦 猛  熊本大学, 病院, 准教授 (90437913)
Project Period (FY) 2016-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsCT / 心臓 / 心筋壁運動 / 4D-CT / 心機能 / ベクトル解析 / 放射線
Outline of Final Research Achievements

The following evaluations were performed on the vector analysis (i-ME method) of myocardial wall motion: 1) the effects of image reconstruction on the image quality improvement and noise reduction; 2) cardiac structure; 3) sum of the pixel-to-pixel myocardial wall motion factors (maximum amount of pixel movement).
We visualized the total cardiac motion by the sum of the motion vectors with color mapping, leading to clear demonstration of change of vector motion. The maximum amount of pixel movement correlated with LVEF and reversely correlated with BNP and cardiac diastolic function.

Academic Significance and Societal Importance of the Research Achievements

本研究では心筋壁の動きを心電図のフェーズごとの画像ピクセルの変化を可視化した。従来の心筋壁運動の評価は全体を左室駆出率(LVEF)のような全体を単一の指標で表現するものが主体であった。また、心臓超音波検査も施行者に依存する部分が多く、解釈の共有も難しい。一方、本研究での手法は再現性があること、ベクトルという一般にも理解しやすい形で図示できることは、心臓疾患の患者が自らの病態を視覚的に理解しやすいという点で社会的にも意義が高いと考える。

Report

(6 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (9 results)

All 2021 2020 2019 2018 2017

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 2 results) Presentation (4 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results)

  • [Journal Article] Effects of Deep Learning Reconstruction Technique in High-Resolution Non-contrast Magnetic Resonance Coronary Angiography at a 3-Tesla Machine2021

    • Author(s)
      Yokota Y, Takeda C, Utsunomiya D et al.
    • Journal Title

      Can Assoc Radiol J

      Volume: 72 Issue: 1 Pages: 120-127

    • DOI

      10.1177/0846537119900469

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Myocardial Late Iodine Enhancement and Extracellular Volume Quantification with Dual-Layer Spectral Detector Dual-Energy Cardiac CT2019

    • Author(s)
      Oda S, Emoto T, Nakaura T, Kidoh M, Utsunomiya D et al.
    • Journal Title

      Radiology: Cardiothoracic Imaging

      Volume: 1 Issue: 1 Pages: e180003-e180003

    • DOI

      10.1148/ryct.2019180003

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tradeoff between noise reduction and inartificial visualization in a model-based iterative reconstruction algorithm on coronary computed tomography angiography2018

    • Author(s)
      Kenichiro Hirata, Daisuke Utsunomiya, Masafumi Kidoh et al.
    • Journal Title

      Medicine (Baltimore)

      Volume: in press

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Vectors through a cross-sectional image (VCI): A visualization method for four-dimensional motion analysis for cardiac computed tomography2017

    • Author(s)
      Kidoh Masafumi、Utsunomiya Daisuke、Funama Yoshinori、Ashikaga Hiroshi、Nakaura Takeshi、Oda Seitaro、Yuki Hideaki、Hirata Kenichiro、Iyama Yuji、Nagayama Yasunori、Fukui Toshihiro、Yamashita Yasuyuki、Taguchi Katsuyuki
    • Journal Title

      J Cardiovasc Comput Tomogr

      Volume: 11 Issue: 6 Pages: 468-473

    • DOI

      10.1016/j.jcct.2017.09.010

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Improved Estimation of Coronary Plaque and Luminal Attenuation Using a Vendor-specific Model-based Iterative Reconstruction Algorithm in Contrast-enhanced CT Coronary Angiography2017

    • Author(s)
      Funama Y, Utsunomiya D, Hirata K, Taguchi K, Nakaura T, Oda S, Kidoh M, Yuki H, Yamashita Y
    • Journal Title

      Academic Radiology

      Volume: 印刷中 Issue: 9 Pages: 1070-1078

    • DOI

      10.1016/j.acra.2017.02.006

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] 心臓CTの臨床:最近のトピックについて考える2020

    • Author(s)
      宇都宮大輔
    • Organizer
      第30回 日本心血管画像動態学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 循環器疾患の おさえておきたい疾患やテクニック2019

    • Author(s)
      宇都宮大輔
    • Organizer
      第189回 日本医学放射線学会九州地方会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 放射線科医の冠疾患へのかかわり2018

    • Author(s)
      宇都宮大輔
    • Organizer
      第32回 日本冠疾患学会学術集会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Tradeoff between noise reduction and inartificial visualization in a model-based iterative reconstruction algorithm on coronary computed tomography angiography2017

    • Author(s)
      Kenichiro Hirata, Daisuke Utsunomiya
    • Organizer
      Society of Cardiovascular Computed Tomography
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2022-01-27  

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