Development of novel theranostics probes with EPR imaging
| Project/Area Number |
16K10291
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Health Sciences University of Hokkaido (2018)
Sapporo Medical University (2016-2017) |
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Principal Investigator |
EMOTO Miho 北海道医療大学, 医療技術学部, 講師 (10578735)
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| Co-Investigator(Kenkyū-buntansha) |
藤井 博匡 札幌医科大学, 医療人育成センター, 教授 (70209013)
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| Research Collaborator |
SATO Shingo
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | EPRイメージング / Theranostics / 抗酸化 / 抗炎症作用 / ナイトロオキサイド / 抗炎症薬 / 炎症モデルマウス / ROS / 酸化ストレス |
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| Outline of Final Research Achievements |
The word ‘theranostic’ was coined in 2002 to describe a compound that exhibits both therapeutic and diagnostic capabilities. Since then, numerous nanoparticle-based theranostics have been created that can be used for hyperthermia or radiation therapy, for example, and/or for the delivery of chemotherapeutic drugs and diagnostic imaging agents. Theranostic probes provide both therapeutic and diagnostic imaging capabilities in one molecule and show significant promise for use in magnetic resonance imaging (MRI)examinations. The present study describes for the first time the synthesis and utility of nitroxide-based contrast agents exhibiting a non steroidal anti-inflammatory drug effect.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究成果によるセラノスティクスの為のプローブを開発・活用することで、個々の病状の観察と、その人にとって最もふさわしい治療を一体化して行うことを目的とした、医療における新しい流れつくる足がかりとなる。この研究により、脳内炎症モデル動物のROS生成状態や分布状況が時系列で解析可能であり、さらに抗炎症作用効果が脳内ラジカル濃度の変化として現れる事が期待される。このようなハイブリッド薬剤の効果を脳内のラジカル量やラジカル分布として計測、画像化する試みは世界初であり、成功すれば医学・薬学界に大きく貢献できるものと考える。
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Evaluation of Mitochondrial Oxidative Stress in the Brain of a Transgenic Mouse Model of Alzheimer's Disease by in vitro Electron Paramagnetic Resonance Spectroscopy.2019
Author(s)
Manabe T, Matsumura A, Yokokawa K, Saito T, Fujikura M, Iwahara N, Matsushita T, Suzuki S, Hisahara S, Kawamata J, Suzuki H, Emoto MC, Fujii HG, Shimohama S.
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Journal Title
Journal of Alzheimer's disease
Volume: 67
Issue: 3
Pages: 1079-1087
DOI
Related Report
Peer Reviewed
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